Experiment: 7H9 with Meropenem 9.6 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0431 and Rv0432 are separated by 32 nucleotides Rv0432 and Rv0433 are separated by 1 nucleotides Rv0433 and Rv0434 are separated by 59 nucleotides Rv0434 and Rv0435c are separated by 179 nucleotides
Rv0431: Rv0431 - Putative tuberculin related peptide, at 519,073 to 519,567
Rv0431
Rv0432: Rv0432 - Periplasmic superoxide dismutase [Cu-Zn] SodC, at 519,600 to 520,322
Rv0432
Rv0433: Rv0433 - Conserved hypothetical protein, at 520,324 to 521,454
Rv0433
Rv0434: Rv0434 - Conserved hypothetical protein, at 521,514 to 522,167
Rv0434
Rv0435c: Rv0435c - Putative conserved ATPase, at 522,347 to 524,533
Rv0435c
Position (kb) 520
521
522 Strain fitness (log2 ratio) -2
-1
0
1
2 at 519.720 kb on - strand, within Rv0432 at 519.822 kb on - strand, within Rv0432 at 519.851 kb on - strand, within Rv0432 at 519.918 kb on - strand, within Rv0432 at 519.918 kb on - strand, within Rv0432 at 519.943 kb on + strand, within Rv0432 at 519.944 kb on - strand, within Rv0432 at 519.963 kb on - strand, within Rv0432 at 519.963 kb on - strand, within Rv0432 at 519.963 kb on - strand, within Rv0432 at 520.032 kb on + strand, within Rv0432 at 520.090 kb on + strand, within Rv0432 at 520.224 kb on + strand, within Rv0432 at 520.320 kb on + strand at 520.536 kb on + strand, within Rv0433 at 520.737 kb on - strand, within Rv0433 at 520.801 kb on + strand, within Rv0433 at 520.802 kb on - strand, within Rv0433 at 520.804 kb on + strand, within Rv0433 at 520.805 kb on - strand, within Rv0433 at 520.805 kb on - strand, within Rv0433 at 520.864 kb on + strand, within Rv0433 at 520.957 kb on + strand, within Rv0433 at 520.957 kb on + strand, within Rv0433 at 520.989 kb on + strand, within Rv0433 at 521.012 kb on + strand, within Rv0433 at 521.012 kb on + strand, within Rv0433 at 521.013 kb on - strand, within Rv0433 at 521.013 kb on - strand, within Rv0433 at 521.508 kb on + strand at 521.508 kb on + strand at 521.509 kb on - strand at 521.509 kb on - strand at 521.509 kb on - strand at 521.665 kb on + strand, within Rv0434 at 521.665 kb on + strand, within Rv0434 at 521.666 kb on - strand, within Rv0434 at 521.666 kb on - strand, within Rv0434 at 521.666 kb on - strand, within Rv0434 at 521.767 kb on - strand, within Rv0434 at 521.767 kb on - strand, within Rv0434 at 521.768 kb on + strand, within Rv0434 at 521.768 kb on + strand, within Rv0434 at 521.768 kb on + strand, within Rv0434 at 521.769 kb on - strand, within Rv0434 at 521.846 kb on - strand, within Rv0434 at 522.165 kb on + strand at 522.166 kb on - strand at 522.229 kb on + strand at 522.230 kb on - strand at 522.230 kb on - strand at 522.231 kb on + strand at 522.231 kb on + strand at 522.231 kb on + strand at 522.231 kb on + strand at 522.231 kb on + strand at 522.232 kb on - strand at 522.232 kb on - strand at 522.379 kb on + strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Meropenem 9.6 ug/mL remove 519,720 - Rv0432 0.17 -0.7 519,822 - Rv0432 0.31 -0.0 519,851 - Rv0432 0.35 -0.7 519,918 - Rv0432 0.44 -0.8 519,918 - Rv0432 0.44 -0.6 519,943 + Rv0432 0.47 +1.1 519,944 - Rv0432 0.48 -0.3 519,963 - Rv0432 0.50 -0.5 519,963 - Rv0432 0.50 -0.3 519,963 - Rv0432 0.50 -0.1 520,032 + Rv0432 0.60 -0.3 520,090 + Rv0432 0.68 -0.0 520,224 + Rv0432 0.86 +0.6 520,320 + -0.4 520,536 + Rv0433 0.19 -0.7 520,737 - Rv0433 0.37 -1.6 520,801 + Rv0433 0.42 -0.1 520,802 - Rv0433 0.42 -0.1 520,804 + Rv0433 0.42 -0.2 520,805 - Rv0433 0.43 +0.3 520,805 - Rv0433 0.43 +0.2 520,864 + Rv0433 0.48 -0.4 520,957 + Rv0433 0.56 -0.4 520,957 + Rv0433 0.56 -0.6 520,989 + Rv0433 0.59 -0.7 521,012 + Rv0433 0.61 +0.4 521,012 + Rv0433 0.61 -0.2 521,013 - Rv0433 0.61 -0.8 521,013 - Rv0433 0.61 -0.6 521,508 + -0.5 521,508 + +0.1 521,509 - -0.8 521,509 - +0.4 521,509 - -0.1 521,665 + Rv0434 0.23 -2.5 521,665 + Rv0434 0.23 +0.3 521,666 - Rv0434 0.23 -0.5 521,666 - Rv0434 0.23 +0.4 521,666 - Rv0434 0.23 -0.3 521,767 - Rv0434 0.39 +1.0 521,767 - Rv0434 0.39 -0.6 521,768 + Rv0434 0.39 -0.1 521,768 + Rv0434 0.39 +0.3 521,768 + Rv0434 0.39 +0.8 521,769 - Rv0434 0.39 +0.1 521,846 - Rv0434 0.51 +0.1 522,165 + +0.2 522,166 - +1.0 522,229 + -0.4 522,230 - -0.1 522,230 - -0.0 522,231 + -1.3 522,231 + +2.7 522,231 + +1.0 522,231 + -0.8 522,231 + -1.0 522,232 - +0.6 522,232 - +0.0 522,379 + -0.3
Or see this region's nucleotide sequence