Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3772

Experiment: 7H9 with Dimethyl Sulfoxide 1 vol%

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3770B and Rv3771c are separated by 134 nucleotidesRv3771c and GFF3924 are separated by 134 nucleotidesGFF3924 and GFF3925 are separated by 30 nucleotidesGFF3925 and Rv3772 are separated by 77 nucleotidesRv3772 and Rv3773c are separated by 45 nucleotidesRv3773c and Rv3774 are separated by 23 nucleotides Rv3770B: Rv3770B - Probable remnant of a transposase, at 4,216,078 to 4,216,269 Rv3770B Rv3771c: Rv3771c - Conserved hypothetical protein, at 4,216,404 to 4,216,730 Rv3771c GFF3924 - tRNA-Arg, at 4,216,865 to 4,216,937 GFF3924 GFF3925 - tRNA-Ser, at 4,216,968 to 4,217,056 GFF3925 Rv3772: Rv3772 - Probable histidinol-phosphate aminotransferase HisC2 (imidazole acetol-phosphate transaminase) (imidazolylacetolphosphate aminotransferase), at 4,217,134 to 4,218,195 Rv3772 Rv3773c: Rv3773c - Conserved protein, at 4,218,241 to 4,218,825 Rv3773c Rv3774: Rv3774 - Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 4,218,849 to 4,219,673 Rv3774 Position (kb) 4217 4218 4219Strain fitness (log2 ratio) -2 -1 0 1at 4216.278 kb on - strandat 4216.525 kb on + strand, within Rv3771cat 4216.526 kb on - strand, within Rv3771cat 4216.743 kb on + strandat 4216.743 kb on + strandat 4216.744 kb on - strandat 4216.744 kb on - strandat 4216.744 kb on - strandat 4216.833 kb on + strandat 4216.834 kb on - strandat 4217.123 kb on - strandat 4217.123 kb on - strandat 4217.692 kb on + strand, within Rv3772at 4217.692 kb on + strand, within Rv3772at 4217.693 kb on - strand, within Rv3772at 4217.701 kb on + strand, within Rv3772at 4217.701 kb on + strand, within Rv3772at 4217.702 kb on - strand, within Rv3772at 4217.702 kb on - strand, within Rv3772at 4217.732 kb on + strand, within Rv3772at 4217.732 kb on + strand, within Rv3772at 4217.733 kb on - strand, within Rv3772at 4217.733 kb on - strand, within Rv3772at 4217.772 kb on + strand, within Rv3772at 4217.861 kb on - strand, within Rv3772at 4217.871 kb on + strand, within Rv3772at 4217.872 kb on - strand, within Rv3772at 4217.941 kb on - strand, within Rv3772at 4218.243 kb on - strandat 4218.337 kb on - strand, within Rv3773cat 4218.373 kb on + strand, within Rv3773cat 4218.380 kb on + strand, within Rv3773cat 4218.381 kb on - strand, within Rv3773cat 4218.511 kb on + strand, within Rv3773cat 4218.511 kb on + strand, within Rv3773cat 4218.511 kb on + strand, within Rv3773cat 4218.512 kb on - strand, within Rv3773cat 4218.512 kb on - strand, within Rv3773cat 4218.512 kb on - strand, within Rv3773cat 4218.826 kb on - strandat 4218.861 kb on + strandat 4219.041 kb on + strand, within Rv3774at 4219.054 kb on + strand, within Rv3774at 4219.055 kb on - strand, within Rv3774at 4219.055 kb on - strand, within Rv3774at 4219.136 kb on - strand, within Rv3774at 4219.136 kb on - strand, within Rv3774

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Dimethyl Sulfoxide 1 vol%
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4,216,278 - -0.4
4,216,525 + Rv3771c 0.37 -0.7
4,216,526 - Rv3771c 0.37 +0.6
4,216,743 + -0.5
4,216,743 + -1.1
4,216,744 - -0.2
4,216,744 - +0.6
4,216,744 - -1.2
4,216,833 + -0.2
4,216,834 - -1.5
4,217,123 - -0.3
4,217,123 - +0.2
4,217,692 + Rv3772 0.53 +0.4
4,217,692 + Rv3772 0.53 +0.2
4,217,693 - Rv3772 0.53 -0.2
4,217,701 + Rv3772 0.53 +0.1
4,217,701 + Rv3772 0.53 +0.1
4,217,702 - Rv3772 0.53 -0.0
4,217,702 - Rv3772 0.53 +1.0
4,217,732 + Rv3772 0.56 +0.1
4,217,732 + Rv3772 0.56 +0.4
4,217,733 - Rv3772 0.56 +1.3
4,217,733 - Rv3772 0.56 -1.3
4,217,772 + Rv3772 0.60 -0.0
4,217,861 - Rv3772 0.68 -0.4
4,217,871 + Rv3772 0.69 +0.1
4,217,872 - Rv3772 0.69 -0.3
4,217,941 - Rv3772 0.76 +0.1
4,218,243 - -0.4
4,218,337 - Rv3773c 0.16 -0.2
4,218,373 + Rv3773c 0.23 -0.3
4,218,380 + Rv3773c 0.24 +0.1
4,218,381 - Rv3773c 0.24 -1.2
4,218,511 + Rv3773c 0.46 -0.1
4,218,511 + Rv3773c 0.46 -0.5
4,218,511 + Rv3773c 0.46 -0.7
4,218,512 - Rv3773c 0.46 -0.1
4,218,512 - Rv3773c 0.46 +0.0
4,218,512 - Rv3773c 0.46 -0.2
4,218,826 - +1.0
4,218,861 + +0.2
4,219,041 + Rv3774 0.23 +0.2
4,219,054 + Rv3774 0.25 -0.4
4,219,055 - Rv3774 0.25 -2.2
4,219,055 - Rv3774 0.25 -0.5
4,219,136 - Rv3774 0.35 -0.1
4,219,136 - Rv3774 0.35 -0.4

Or see this region's nucleotide sequence