Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2431c

Experiment: 7H9 with Dimethyl Sulfoxide 1 vol%

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2429 and Rv2430c overlap by 4 nucleotidesRv2430c and Rv2431c are separated by 46 nucleotidesRv2431c and Rv2432c are separated by 170 nucleotidesRv2432c and Rv2433c overlap by 4 nucleotidesRv2433c and Rv2434c overlap by 20 nucleotides Rv2429: Rv2429 - Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D), at 2,726,806 to 2,727,339 Rv2429 Rv2430c: Rv2430c - PPE family protein PPE41, at 2,727,336 to 2,727,920 Rv2430c Rv2431c: Rv2431c - PE family protein PE25, at 2,727,967 to 2,728,266 Rv2431c Rv2432c: Rv2432c - Hypothetical protein, at 2,728,437 to 2,728,847 Rv2432c Rv2433c: Rv2433c - Hypothetical protein, at 2,728,844 to 2,729,134 Rv2433c Rv2434c: Rv2434c - Probable conserved transmembrane protein, at 2,729,115 to 2,730,560 Rv2434c Position (kb) 2727 2728 2729Strain fitness (log2 ratio) -1 0 1 2at 2727.236 kb on + strand, within Rv2429at 2727.326 kb on + strandat 2727.327 kb on - strandat 2727.327 kb on - strandat 2727.338 kb on - strandat 2727.463 kb on + strand, within Rv2430cat 2727.464 kb on - strand, within Rv2430cat 2727.464 kb on - strand, within Rv2430cat 2727.506 kb on - strand, within Rv2430cat 2727.593 kb on - strand, within Rv2430cat 2727.615 kb on - strand, within Rv2430cat 2727.634 kb on + strand, within Rv2430cat 2727.634 kb on + strand, within Rv2430cat 2727.874 kb on + strandat 2727.875 kb on - strandat 2727.876 kb on + strandat 2727.877 kb on - strandat 2727.877 kb on - strandat 2727.877 kb on - strandat 2727.969 kb on - strandat 2728.007 kb on + strand, within Rv2431cat 2728.007 kb on + strand, within Rv2431cat 2728.008 kb on - strand, within Rv2431cat 2728.008 kb on - strand, within Rv2431cat 2728.008 kb on - strand, within Rv2431cat 2728.008 kb on - strand, within Rv2431cat 2728.008 kb on - strand, within Rv2431cat 2728.083 kb on - strand, within Rv2431cat 2728.094 kb on + strand, within Rv2431cat 2728.379 kb on + strandat 2728.379 kb on + strandat 2728.383 kb on + strandat 2728.384 kb on - strandat 2728.498 kb on + strand, within Rv2432cat 2728.504 kb on - strand, within Rv2432cat 2728.681 kb on - strand, within Rv2432cat 2728.938 kb on + strand, within Rv2433cat 2729.015 kb on + strand, within Rv2433cat 2729.015 kb on + strand, within Rv2433cat 2729.015 kb on + strand, within Rv2433c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Dimethyl Sulfoxide 1 vol%
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2,727,236 + Rv2429 0.81 +2.0
2,727,326 + +0.3
2,727,327 - -0.3
2,727,327 - -0.4
2,727,338 - -0.3
2,727,463 + Rv2430c 0.22 -0.9
2,727,464 - Rv2430c 0.22 +0.0
2,727,464 - Rv2430c 0.22 +0.2
2,727,506 - Rv2430c 0.29 +1.2
2,727,593 - Rv2430c 0.44 +0.0
2,727,615 - Rv2430c 0.48 -0.6
2,727,634 + Rv2430c 0.51 -0.3
2,727,634 + Rv2430c 0.51 -0.9
2,727,874 + +0.0
2,727,875 - -1.0
2,727,876 + -0.1
2,727,877 - -0.0
2,727,877 - -0.4
2,727,877 - -0.5
2,727,969 - -0.3
2,728,007 + Rv2431c 0.13 +1.6
2,728,007 + Rv2431c 0.13 -0.1
2,728,008 - Rv2431c 0.14 -0.5
2,728,008 - Rv2431c 0.14 +1.3
2,728,008 - Rv2431c 0.14 -0.0
2,728,008 - Rv2431c 0.14 -0.0
2,728,008 - Rv2431c 0.14 -0.2
2,728,083 - Rv2431c 0.39 -0.1
2,728,094 + Rv2431c 0.42 +0.1
2,728,379 + +0.8
2,728,379 + +0.0
2,728,383 + +0.7
2,728,384 - -0.0
2,728,498 + Rv2432c 0.15 -0.3
2,728,504 - Rv2432c 0.16 +1.3
2,728,681 - Rv2432c 0.59 +0.8
2,728,938 + Rv2433c 0.32 -0.8
2,729,015 + Rv2433c 0.59 -0.2
2,729,015 + Rv2433c 0.59 -1.0
2,729,015 + Rv2433c 0.59 +0.9

Or see this region's nucleotide sequence