Strain Fitness in Escherichia coli Nissle 1917 around ECOLIN_RS11515

Experiment: JK16

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntECOLIN_RS11505 and ECOLIN_RS11510 are separated by 34 nucleotidesECOLIN_RS11510 and ECOLIN_RS11515 overlap by 8 nucleotidesECOLIN_RS11515 and ECOLIN_RS11520 are separated by 12 nucleotides ECOLIN_RS11505: ECOLIN_RS11505 - colibactin self-protection protein ClbS, at 2,239,798 to 2,240,310 _RS11505 ECOLIN_RS11510: ECOLIN_RS11510 - colibactin biosynthesis thioesterase ClbQ, at 2,240,345 to 2,241,067 _RS11510 ECOLIN_RS11515: ECOLIN_RS11515 - precolibactin peptidase ClbP, at 2,241,060 to 2,242,574 _RS11515 ECOLIN_RS11520: ECOLIN_RS11520 - colibactin polyketide synthase ClbO, at 2,242,587 to 2,245,046 _RS11520 Position (kb) 2241 2242 2243Strain fitness (log2 ratio) -1 0 1at 2241.213 kb on + strand, within ECOLIN_RS11515at 2242.137 kb on - strand, within ECOLIN_RS11515at 2242.538 kb on - strandat 2243.233 kb on + strand, within ECOLIN_RS11520at 2243.475 kb on + strand, within ECOLIN_RS11520

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Per-strain Table

Position Strand Gene LocusTag Fraction JK16
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2,241,213 + ECOLIN_RS11515 0.10 +0.3
2,242,137 - ECOLIN_RS11515 0.71 +0.7
2,242,538 - -0.6
2,243,233 + ECOLIN_RS11520 0.26 -0.4
2,243,475 + ECOLIN_RS11520 0.36 +0.1

Or see this region's nucleotide sequence