Experiment: Defined media control, aerobic
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt IAI47_09150 and IAI47_09155 are separated by 250 nucleotides IAI47_09155 and IAI47_09160 are separated by 48 nucleotides IAI47_09160 and IAI47_09165 are separated by 149 nucleotides IAI47_09165 and IAI47_09170 overlap by 1 nucleotides
IAI47_09150: IAI47_09150 - YkgJ family cysteine cluster protein, at 1,928,949 to 1,929,365
_09150
IAI47_09155: IAI47_09155 - outer membrane protein OmpW, at 1,929,616 to 1,930,251
_09155
IAI47_09160: IAI47_09160 - BON domain-containing protein, at 1,930,300 to 1,930,614
_09160
IAI47_09165: IAI47_09165 - tryptophan synthase subunit alpha, at 1,930,764 to 1,931,567
_09165
IAI47_09170: IAI47_09170 - tryptophan synthase subunit beta, at 1,931,567 to 1,932,757
_09170
Position (kb)
1930
1931 Strain fitness (log2 ratio)
-4
-3
-2
-1
0
1
2
3
4
5 at 1929.415 kb on + strand at 1929.415 kb on + strand at 1929.415 kb on + strand at 1929.415 kb on + strand at 1929.415 kb on + strand at 1929.416 kb on - strand at 1929.424 kb on + strand at 1929.424 kb on + strand at 1929.425 kb on - strand at 1929.425 kb on - strand at 1929.591 kb on + strand at 1929.602 kb on + strand at 1929.602 kb on + strand at 1929.603 kb on - strand at 1929.603 kb on - strand at 1929.804 kb on + strand, within IAI47_09155 at 1929.804 kb on + strand, within IAI47_09155 at 1929.804 kb on + strand, within IAI47_09155 at 1929.804 kb on + strand, within IAI47_09155 at 1929.805 kb on - strand, within IAI47_09155 at 1929.805 kb on - strand, within IAI47_09155 at 1929.805 kb on - strand, within IAI47_09155 at 1929.805 kb on - strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.808 kb on + strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.809 kb on - strand, within IAI47_09155 at 1929.810 kb on + strand, within IAI47_09155 at 1929.810 kb on + strand, within IAI47_09155 at 1929.810 kb on + strand, within IAI47_09155 at 1929.810 kb on + strand, within IAI47_09155 at 1929.811 kb on - strand, within IAI47_09155 at 1929.864 kb on + strand, within IAI47_09155 at 1929.911 kb on + strand, within IAI47_09155 at 1929.911 kb on + strand, within IAI47_09155 at 1929.911 kb on + strand, within IAI47_09155 at 1929.934 kb on + strand, within IAI47_09155 at 1929.935 kb on - strand, within IAI47_09155 at 1929.937 kb on + strand, within IAI47_09155 at 1929.937 kb on + strand, within IAI47_09155 at 1929.957 kb on + strand, within IAI47_09155 at 1929.958 kb on - strand, within IAI47_09155 at 1929.958 kb on - strand, within IAI47_09155 at 1929.970 kb on + strand, within IAI47_09155 at 1929.970 kb on + strand, within IAI47_09155 at 1929.970 kb on + strand, within IAI47_09155 at 1929.970 kb on + strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.971 kb on - strand, within IAI47_09155 at 1929.981 kb on - strand, within IAI47_09155 at 1929.981 kb on - strand, within IAI47_09155 at 1929.981 kb on - strand, within IAI47_09155 at 1929.984 kb on + strand, within IAI47_09155 at 1929.985 kb on - strand, within IAI47_09155 at 1929.991 kb on + strand, within IAI47_09155 at 1929.992 kb on - strand, within IAI47_09155 at 1930.003 kb on + strand, within IAI47_09155 at 1930.003 kb on + strand, within IAI47_09155 at 1930.003 kb on + strand, within IAI47_09155 at 1930.004 kb on - strand, within IAI47_09155 at 1930.004 kb on - strand, within IAI47_09155 at 1930.004 kb on - strand, within IAI47_09155 at 1930.004 kb on - strand, within IAI47_09155 at 1930.004 kb on - strand, within IAI47_09155 at 1930.004 kb on - strand, within IAI47_09155 at 1930.141 kb on + strand, within IAI47_09155 at 1930.141 kb on + strand, within IAI47_09155 at 1930.141 kb on + strand, within IAI47_09155 at 1930.141 kb on + strand, within IAI47_09155 at 1930.141 kb on + strand, within IAI47_09155 at 1930.142 kb on - strand, within IAI47_09155 at 1930.149 kb on + strand, within IAI47_09155 at 1930.149 kb on + strand, within IAI47_09155 at 1930.150 kb on - strand, within IAI47_09155 at 1930.200 kb on + strand at 1930.200 kb on + strand at 1930.200 kb on + strand at 1930.200 kb on + strand at 1930.293 kb on + strand at 1930.294 kb on - strand at 1930.294 kb on - strand at 1930.294 kb on - strand at 1930.302 kb on - strand at 1930.302 kb on - strand at 1930.302 kb on - strand at 1930.360 kb on + strand, within IAI47_09160 at 1930.361 kb on - strand, within IAI47_09160 at 1930.361 kb on - strand, within IAI47_09160 at 1930.371 kb on + strand, within IAI47_09160 at 1930.413 kb on + strand, within IAI47_09160 at 1930.413 kb on + strand, within IAI47_09160 at 1930.413 kb on + strand, within IAI47_09160 at 1930.414 kb on - strand, within IAI47_09160 at 1930.414 kb on - strand, within IAI47_09160 at 1930.419 kb on + strand, within IAI47_09160 at 1930.420 kb on - strand, within IAI47_09160 at 1930.429 kb on + strand, within IAI47_09160 at 1930.429 kb on + strand, within IAI47_09160 at 1930.429 kb on + strand, within IAI47_09160 at 1930.429 kb on + strand, within IAI47_09160 at 1930.429 kb on + strand, within IAI47_09160 at 1930.430 kb on - strand, within IAI47_09160 at 1930.479 kb on + strand, within IAI47_09160 at 1930.479 kb on + strand, within IAI47_09160 at 1930.496 kb on - strand, within IAI47_09160 at 1930.509 kb on + strand, within IAI47_09160 at 1930.509 kb on + strand, within IAI47_09160 at 1930.510 kb on - strand, within IAI47_09160 at 1930.510 kb on - strand, within IAI47_09160 at 1930.510 kb on - strand, within IAI47_09160 at 1930.510 kb on - strand, within IAI47_09160 at 1930.511 kb on + strand, within IAI47_09160 at 1930.511 kb on + strand, within IAI47_09160 at 1930.511 kb on + strand, within IAI47_09160 at 1930.511 kb on + strand, within IAI47_09160 at 1930.511 kb on + strand, within IAI47_09160 at 1930.511 kb on + strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.512 kb on - strand, within IAI47_09160 at 1930.582 kb on + strand, within IAI47_09160 at 1930.701 kb on + strand at 1930.702 kb on - strand at 1930.737 kb on - strand at 1930.746 kb on + strand at 1930.746 kb on + strand at 1930.765 kb on + strand at 1930.960 kb on + strand, within IAI47_09165 at 1931.044 kb on + strand, within IAI47_09165 at 1931.044 kb on + strand, within IAI47_09165 at 1931.044 kb on + strand, within IAI47_09165 at 1931.044 kb on + strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.045 kb on - strand, within IAI47_09165 at 1931.048 kb on + strand, within IAI47_09165 at 1931.048 kb on + strand, within IAI47_09165 at 1931.048 kb on + strand, within IAI47_09165 at 1931.048 kb on + strand, within IAI47_09165 at 1931.048 kb on + strand, within IAI47_09165 at 1931.048 kb on + strand, within IAI47_09165 at 1931.048 kb on + strand, within IAI47_09165 at 1931.049 kb on - strand, within IAI47_09165 at 1931.049 kb on - strand, within IAI47_09165 at 1931.049 kb on - strand, within IAI47_09165 at 1931.049 kb on - strand, within IAI47_09165 at 1931.049 kb on - strand, within IAI47_09165 at 1931.049 kb on - strand, within IAI47_09165 at 1931.049 kb on - strand, within IAI47_09165 at 1931.050 kb on + strand, within IAI47_09165 at 1931.050 kb on + strand, within IAI47_09165 at 1931.111 kb on + strand, within IAI47_09165 at 1931.111 kb on + strand, within IAI47_09165 at 1931.111 kb on + strand, within IAI47_09165 at 1931.111 kb on + strand, within IAI47_09165 at 1931.112 kb on - strand, within IAI47_09165 at 1931.112 kb on - strand, within IAI47_09165 at 1931.112 kb on - strand, within IAI47_09165 at 1931.112 kb on - strand, within IAI47_09165 at 1931.112 kb on - strand, within IAI47_09165 at 1931.117 kb on + strand, within IAI47_09165 at 1931.118 kb on - strand, within IAI47_09165 at 1931.118 kb on - strand, within IAI47_09165 at 1931.224 kb on + strand, within IAI47_09165 at 1931.224 kb on + strand, within IAI47_09165 at 1931.263 kb on + strand, within IAI47_09165 at 1931.263 kb on + strand, within IAI47_09165 at 1931.263 kb on + strand, within IAI47_09165 at 1931.263 kb on + strand, within IAI47_09165 at 1931.264 kb on - strand, within IAI47_09165 at 1931.264 kb on - strand, within IAI47_09165 at 1931.264 kb on - strand, within IAI47_09165 at 1931.264 kb on - strand, within IAI47_09165 at 1931.264 kb on - strand, within IAI47_09165 at 1931.264 kb on - strand, within IAI47_09165 at 1931.272 kb on - strand, within IAI47_09165 at 1931.272 kb on - strand, within IAI47_09165 at 1931.306 kb on + strand, within IAI47_09165 at 1931.544 kb on - strand at 1931.557 kb on + strand at 1931.557 kb on + strand at 1931.558 kb on - strand at 1931.558 kb on - strand at 1931.611 kb on + strand
Per-strain Table
Position Strand Gene LocusTag Fraction Defined media control, aerobic remove 1,929,415 + -0.3 1,929,415 + -0.4 1,929,415 + +1.0 1,929,415 + +0.4 1,929,415 + -0.0 1,929,416 - +1.3 1,929,424 + +0.2 1,929,424 + -1.3 1,929,425 - -2.5 1,929,425 - -1.7 1,929,591 + +1.6 1,929,602 + +0.6 1,929,602 + +2.0 1,929,603 - +0.1 1,929,603 - +1.4 1,929,804 + IAI47_09155 0.30 +1.5 1,929,804 + IAI47_09155 0.30 -0.7 1,929,804 + IAI47_09155 0.30 +1.3 1,929,804 + IAI47_09155 0.30 -3.2 1,929,805 - IAI47_09155 0.30 +1.8 1,929,805 - IAI47_09155 0.30 -0.1 1,929,805 - IAI47_09155 0.30 +0.4 1,929,805 - IAI47_09155 0.30 -2.0 1,929,808 + IAI47_09155 0.30 -0.1 1,929,808 + IAI47_09155 0.30 -2.3 1,929,808 + IAI47_09155 0.30 +0.4 1,929,808 + IAI47_09155 0.30 -0.9 1,929,808 + IAI47_09155 0.30 -0.6 1,929,808 + IAI47_09155 0.30 +0.5 1,929,808 + IAI47_09155 0.30 +0.8 1,929,808 + IAI47_09155 0.30 -2.7 1,929,808 + IAI47_09155 0.30 -0.3 1,929,808 + IAI47_09155 0.30 +0.5 1,929,808 + IAI47_09155 0.30 +0.1 1,929,808 + IAI47_09155 0.30 -2.5 1,929,809 - IAI47_09155 0.30 +4.3 1,929,809 - IAI47_09155 0.30 +3.3 1,929,809 - IAI47_09155 0.30 +1.8 1,929,809 - IAI47_09155 0.30 +0.1 1,929,809 - IAI47_09155 0.30 -0.2 1,929,809 - IAI47_09155 0.30 -1.0 1,929,809 - IAI47_09155 0.30 +0.4 1,929,809 - IAI47_09155 0.30 +1.0 1,929,809 - IAI47_09155 0.30 -2.2 1,929,810 + IAI47_09155 0.31 -0.7 1,929,810 + IAI47_09155 0.31 -1.0 1,929,810 + IAI47_09155 0.31 -0.8 1,929,810 + IAI47_09155 0.31 +0.7 1,929,811 - IAI47_09155 0.31 -1.4 1,929,864 + IAI47_09155 0.39 +0.3 1,929,911 + IAI47_09155 0.46 +0.7 1,929,911 + IAI47_09155 0.46 +0.9 1,929,911 + IAI47_09155 0.46 +0.8 1,929,934 + IAI47_09155 0.50 +3.0 1,929,935 - IAI47_09155 0.50 -0.6 1,929,937 + IAI47_09155 0.50 -0.2 1,929,937 + IAI47_09155 0.50 -1.0 1,929,957 + IAI47_09155 0.54 -0.3 1,929,958 - IAI47_09155 0.54 +0.6 1,929,958 - IAI47_09155 0.54 +0.7 1,929,970 + IAI47_09155 0.56 -0.6 1,929,970 + IAI47_09155 0.56 -0.1 1,929,970 + IAI47_09155 0.56 +1.8 1,929,970 + IAI47_09155 0.56 +1.1 1,929,971 - IAI47_09155 0.56 -3.3 1,929,971 - IAI47_09155 0.56 -0.4 1,929,971 - IAI47_09155 0.56 +2.7 1,929,971 - IAI47_09155 0.56 -2.2 1,929,971 - IAI47_09155 0.56 +2.7 1,929,971 - IAI47_09155 0.56 +0.4 1,929,971 - IAI47_09155 0.56 -3.1 1,929,971 - IAI47_09155 0.56 -3.1 1,929,971 - IAI47_09155 0.56 +1.7 1,929,971 - IAI47_09155 0.56 +1.0 1,929,971 - IAI47_09155 0.56 +1.9 1,929,981 - IAI47_09155 0.57 -1.9 1,929,981 - IAI47_09155 0.57 -1.5 1,929,981 - IAI47_09155 0.57 -1.1 1,929,984 + IAI47_09155 0.58 +1.7 1,929,985 - IAI47_09155 0.58 -1.8 1,929,991 + IAI47_09155 0.59 -0.3 1,929,992 - IAI47_09155 0.59 -1.5 1,930,003 + IAI47_09155 0.61 +2.2 1,930,003 + IAI47_09155 0.61 +1.3 1,930,003 + IAI47_09155 0.61 -1.8 1,930,004 - IAI47_09155 0.61 +1.8 1,930,004 - IAI47_09155 0.61 +0.3 1,930,004 - IAI47_09155 0.61 -0.1 1,930,004 - IAI47_09155 0.61 +1.0 1,930,004 - IAI47_09155 0.61 +2.0 1,930,004 - IAI47_09155 0.61 +2.2 1,930,141 + IAI47_09155 0.83 -1.0 1,930,141 + IAI47_09155 0.83 +0.7 1,930,141 + IAI47_09155 0.83 +5.3 1,930,141 + IAI47_09155 0.83 -0.2 1,930,141 + IAI47_09155 0.83 +0.5 1,930,142 - IAI47_09155 0.83 -0.8 1,930,149 + IAI47_09155 0.84 +1.8 1,930,149 + IAI47_09155 0.84 -3.0 1,930,150 - IAI47_09155 0.84 +1.1 1,930,200 + -0.0 1,930,200 + +2.0 1,930,200 + -1.7 1,930,200 + +2.0 1,930,293 + -1.0 1,930,294 - -0.0 1,930,294 - +0.3 1,930,294 - -0.1 1,930,302 - +0.1 1,930,302 - +0.5 1,930,302 - +1.2 1,930,360 + IAI47_09160 0.19 +0.2 1,930,361 - IAI47_09160 0.19 -0.3 1,930,361 - IAI47_09160 0.19 -1.3 1,930,371 + IAI47_09160 0.23 -0.8 1,930,413 + IAI47_09160 0.36 +0.7 1,930,413 + IAI47_09160 0.36 +2.3 1,930,413 + IAI47_09160 0.36 +0.5 1,930,414 - IAI47_09160 0.36 +0.4 1,930,414 - IAI47_09160 0.36 -0.3 1,930,419 + IAI47_09160 0.38 -0.2 1,930,420 - IAI47_09160 0.38 -0.6 1,930,429 + IAI47_09160 0.41 +2.3 1,930,429 + IAI47_09160 0.41 +0.3 1,930,429 + IAI47_09160 0.41 +0.3 1,930,429 + IAI47_09160 0.41 +0.6 1,930,429 + IAI47_09160 0.41 +0.5 1,930,430 - IAI47_09160 0.41 -0.7 1,930,479 + IAI47_09160 0.57 +0.0 1,930,479 + IAI47_09160 0.57 -0.1 1,930,496 - IAI47_09160 0.62 +2.5 1,930,509 + IAI47_09160 0.66 +2.0 1,930,509 + IAI47_09160 0.66 -1.0 1,930,510 - IAI47_09160 0.67 -0.8 1,930,510 - IAI47_09160 0.67 -0.9 1,930,510 - IAI47_09160 0.67 +0.5 1,930,510 - IAI47_09160 0.67 -0.5 1,930,511 + IAI47_09160 0.67 +0.3 1,930,511 + IAI47_09160 0.67 -0.3 1,930,511 + IAI47_09160 0.67 -1.2 1,930,511 + IAI47_09160 0.67 -3.1 1,930,511 + IAI47_09160 0.67 +0.7 1,930,511 + IAI47_09160 0.67 +1.9 1,930,512 - IAI47_09160 0.67 -0.5 1,930,512 - IAI47_09160 0.67 -0.8 1,930,512 - IAI47_09160 0.67 -1.7 1,930,512 - IAI47_09160 0.67 -1.9 1,930,512 - IAI47_09160 0.67 -3.0 1,930,512 - IAI47_09160 0.67 +0.6 1,930,512 - IAI47_09160 0.67 +0.9 1,930,512 - IAI47_09160 0.67 -0.0 1,930,512 - IAI47_09160 0.67 +0.4 1,930,582 + IAI47_09160 0.90 -1.1 1,930,701 + +0.2 1,930,702 - -2.2 1,930,737 - -0.1 1,930,746 + -0.5 1,930,746 + +0.8 1,930,765 + +0.5 1,930,960 + IAI47_09165 0.24 -2.0 1,931,044 + IAI47_09165 0.35 -2.5 1,931,044 + IAI47_09165 0.35 -2.7 1,931,044 + IAI47_09165 0.35 -0.6 1,931,044 + IAI47_09165 0.35 -2.4 1,931,045 - IAI47_09165 0.35 +2.0 1,931,045 - IAI47_09165 0.35 -2.1 1,931,045 - IAI47_09165 0.35 -0.0 1,931,045 - IAI47_09165 0.35 -1.6 1,931,045 - IAI47_09165 0.35 -2.9 1,931,045 - IAI47_09165 0.35 +1.3 1,931,045 - IAI47_09165 0.35 -4.5 1,931,045 - IAI47_09165 0.35 -1.8 1,931,045 - IAI47_09165 0.35 -1.5 1,931,048 + IAI47_09165 0.35 -1.8 1,931,048 + IAI47_09165 0.35 -0.8 1,931,048 + IAI47_09165 0.35 -1.5 1,931,048 + IAI47_09165 0.35 -2.2 1,931,048 + IAI47_09165 0.35 -2.2 1,931,048 + IAI47_09165 0.35 -1.8 1,931,048 + IAI47_09165 0.35 -0.0 1,931,049 - IAI47_09165 0.35 -2.4 1,931,049 - IAI47_09165 0.35 -2.6 1,931,049 - IAI47_09165 0.35 -1.5 1,931,049 - IAI47_09165 0.35 -1.5 1,931,049 - IAI47_09165 0.35 -1.3 1,931,049 - IAI47_09165 0.35 -1.3 1,931,049 - IAI47_09165 0.35 -1.7 1,931,050 + IAI47_09165 0.36 -1.2 1,931,050 + IAI47_09165 0.36 -3.2 1,931,111 + IAI47_09165 0.43 -3.4 1,931,111 + IAI47_09165 0.43 -0.8 1,931,111 + IAI47_09165 0.43 -0.8 1,931,111 + IAI47_09165 0.43 -2.6 1,931,112 - IAI47_09165 0.43 -1.3 1,931,112 - IAI47_09165 0.43 -3.2 1,931,112 - IAI47_09165 0.43 -1.8 1,931,112 - IAI47_09165 0.43 -2.1 1,931,112 - IAI47_09165 0.43 -1.3 1,931,117 + IAI47_09165 0.44 -1.9 1,931,118 - IAI47_09165 0.44 -2.0 1,931,118 - IAI47_09165 0.44 -0.8 1,931,224 + IAI47_09165 0.57 -2.0 1,931,224 + IAI47_09165 0.57 -2.3 1,931,263 + IAI47_09165 0.62 -1.2 1,931,263 + IAI47_09165 0.62 -2.7 1,931,263 + IAI47_09165 0.62 +2.0 1,931,263 + IAI47_09165 0.62 -2.1 1,931,264 - IAI47_09165 0.62 -2.0 1,931,264 - IAI47_09165 0.62 -3.1 1,931,264 - IAI47_09165 0.62 -0.8 1,931,264 - IAI47_09165 0.62 -2.6 1,931,264 - IAI47_09165 0.62 -2.2 1,931,264 - IAI47_09165 0.62 -2.2 1,931,272 - IAI47_09165 0.63 -2.3 1,931,272 - IAI47_09165 0.63 -3.7 1,931,306 + IAI47_09165 0.67 -3.6 1,931,544 - -2.3 1,931,557 + -0.0 1,931,557 + -3.7 1,931,558 - -4.5 1,931,558 - -3.7 1,931,611 + -1.6
Or see this region's nucleotide sequence