Experiment: Cisplatin 0.006 mg/ml
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt AO353_20755 and AO353_20760 are separated by 16 nucleotides AO353_20760 and AO353_20765 are separated by 162 nucleotides AO353_20765 and AO353_20770 are separated by 159 nucleotides AO353_20770 and AO353_20775 are separated by 250 nucleotides
AO353_20755: AO353_20755 - serine/threonine protein phosphatase, at 4,550,260 to 4,550,982
_20755
AO353_20760: AO353_20760 - hypothetical protein, at 4,550,999 to 4,551,181
_20760
AO353_20765: AO353_20765 - NADPH-dependent FMN reductase, at 4,551,344 to 4,551,892
_20765
AO353_20770: AO353_20770 - hypothetical protein, at 4,552,052 to 4,552,252
_20770
AO353_20775: AO353_20775 - alpha/beta hydrolase, at 4,552,503 to 4,553,204
_20775
Position (kb)
4551
4552 Strain fitness (log2 ratio)
-4
-3
-2
-1
0
1
2
3
4 at 4550.523 kb on + strand, within AO353_20755 at 4550.524 kb on - strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.539 kb on + strand, within AO353_20755 at 4550.540 kb on - strand, within AO353_20755 at 4550.540 kb on - strand, within AO353_20755 at 4550.540 kb on - strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.543 kb on + strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.544 kb on - strand, within AO353_20755 at 4550.573 kb on - strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.602 kb on + strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.603 kb on - strand, within AO353_20755 at 4550.642 kb on + strand, within AO353_20755 at 4550.642 kb on + strand, within AO353_20755 at 4550.643 kb on - strand, within AO353_20755 at 4550.643 kb on - strand, within AO353_20755 at 4550.643 kb on - strand, within AO353_20755 at 4550.652 kb on + strand, within AO353_20755 at 4550.748 kb on + strand, within AO353_20755 at 4550.748 kb on + strand, within AO353_20755 at 4550.748 kb on + strand, within AO353_20755 at 4550.748 kb on + strand, within AO353_20755 at 4550.749 kb on - strand, within AO353_20755 at 4550.749 kb on - strand, within AO353_20755 at 4550.749 kb on - strand, within AO353_20755 at 4550.760 kb on + strand, within AO353_20755 at 4550.760 kb on + strand, within AO353_20755 at 4550.760 kb on + strand, within AO353_20755 at 4550.761 kb on - strand, within AO353_20755 at 4550.761 kb on - strand, within AO353_20755 at 4550.787 kb on + strand, within AO353_20755 at 4550.788 kb on - strand, within AO353_20755 at 4550.802 kb on + strand, within AO353_20755 at 4550.878 kb on + strand, within AO353_20755 at 4550.879 kb on - strand, within AO353_20755 at 4550.935 kb on - strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.946 kb on + strand at 4550.947 kb on - strand at 4550.947 kb on - strand at 4551.021 kb on + strand, within AO353_20760 at 4551.021 kb on + strand, within AO353_20760 at 4551.022 kb on - strand, within AO353_20760 at 4551.022 kb on - strand, within AO353_20760 at 4551.022 kb on - strand, within AO353_20760 at 4551.022 kb on - strand, within AO353_20760 at 4551.022 kb on - strand, within AO353_20760 at 4551.045 kb on + strand, within AO353_20760 at 4551.045 kb on + strand, within AO353_20760 at 4551.045 kb on + strand, within AO353_20760 at 4551.045 kb on + strand, within AO353_20760 at 4551.045 kb on + strand, within AO353_20760 at 4551.046 kb on - strand, within AO353_20760 at 4551.046 kb on - strand, within AO353_20760 at 4551.046 kb on - strand, within AO353_20760 at 4551.046 kb on - strand, within AO353_20760 at 4551.118 kb on + strand, within AO353_20760 at 4551.119 kb on - strand, within AO353_20760 at 4551.231 kb on + strand at 4551.231 kb on + strand at 4551.232 kb on - strand at 4551.301 kb on - strand at 4551.301 kb on - strand at 4551.337 kb on + strand at 4551.338 kb on - strand at 4551.338 kb on - strand at 4551.338 kb on - strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.339 kb on + strand at 4551.340 kb on - strand at 4551.340 kb on - strand at 4551.340 kb on - strand at 4551.340 kb on - strand at 4551.340 kb on - strand at 4551.340 kb on - strand at 4551.340 kb on - strand at 4551.403 kb on - strand, within AO353_20765 at 4551.452 kb on + strand, within AO353_20765 at 4551.453 kb on - strand, within AO353_20765 at 4551.471 kb on + strand, within AO353_20765 at 4551.471 kb on + strand, within AO353_20765 at 4551.471 kb on + strand, within AO353_20765 at 4551.471 kb on + strand, within AO353_20765 at 4551.472 kb on - strand, within AO353_20765 at 4551.472 kb on - strand, within AO353_20765 at 4551.472 kb on - strand, within AO353_20765 at 4551.472 kb on - strand, within AO353_20765 at 4551.472 kb on - strand, within AO353_20765 at 4551.708 kb on + strand, within AO353_20765 at 4551.708 kb on + strand, within AO353_20765 at 4551.708 kb on + strand, within AO353_20765 at 4551.709 kb on - strand, within AO353_20765 at 4551.709 kb on - strand, within AO353_20765 at 4551.709 kb on - strand, within AO353_20765 at 4551.733 kb on + strand, within AO353_20765 at 4551.733 kb on + strand, within AO353_20765 at 4551.772 kb on + strand, within AO353_20765 at 4551.951 kb on + strand at 4551.951 kb on + strand at 4551.951 kb on + strand at 4551.952 kb on - strand at 4551.952 kb on - strand at 4551.952 kb on - strand at 4552.020 kb on + strand at 4552.020 kb on + strand at 4552.021 kb on - strand at 4552.021 kb on - strand at 4552.021 kb on - strand at 4552.021 kb on - strand at 4552.021 kb on - strand at 4552.029 kb on + strand at 4552.030 kb on - strand at 4552.051 kb on + strand at 4552.052 kb on - strand at 4552.052 kb on - strand at 4552.078 kb on + strand, within AO353_20770 at 4552.078 kb on + strand, within AO353_20770 at 4552.078 kb on + strand, within AO353_20770 at 4552.079 kb on - strand, within AO353_20770 at 4552.079 kb on - strand, within AO353_20770 at 4552.079 kb on - strand, within AO353_20770 at 4552.079 kb on - strand, within AO353_20770 at 4552.109 kb on + strand, within AO353_20770 at 4552.110 kb on - strand, within AO353_20770 at 4552.110 kb on - strand, within AO353_20770 at 4552.197 kb on + strand, within AO353_20770 at 4552.197 kb on + strand, within AO353_20770 at 4552.197 kb on + strand, within AO353_20770 at 4552.198 kb on - strand, within AO353_20770 at 4552.198 kb on - strand, within AO353_20770 at 4552.198 kb on - strand, within AO353_20770 at 4552.250 kb on + strand at 4552.250 kb on + strand at 4552.251 kb on - strand at 4552.430 kb on + strand at 4552.464 kb on - strand at 4552.465 kb on + strand at 4552.465 kb on + strand at 4552.465 kb on + strand at 4552.466 kb on - strand at 4552.466 kb on - strand at 4552.596 kb on + strand, within AO353_20775 at 4552.596 kb on + strand, within AO353_20775 at 4552.596 kb on + strand, within AO353_20775 at 4552.596 kb on + strand, within AO353_20775 at 4552.596 kb on + strand, within AO353_20775 at 4552.596 kb on + strand, within AO353_20775 at 4552.597 kb on - strand, within AO353_20775 at 4552.597 kb on - strand, within AO353_20775 at 4552.597 kb on - strand, within AO353_20775 at 4552.597 kb on - strand, within AO353_20775 at 4552.597 kb on - strand, within AO353_20775 at 4552.597 kb on - strand, within AO353_20775 at 4552.597 kb on - strand, within AO353_20775 at 4552.641 kb on + strand, within AO353_20775 at 4552.669 kb on + strand, within AO353_20775 at 4552.669 kb on + strand, within AO353_20775 at 4552.669 kb on + strand, within AO353_20775 at 4552.670 kb on - strand, within AO353_20775 at 4552.670 kb on - strand, within AO353_20775 at 4552.670 kb on - strand, within AO353_20775 at 4552.818 kb on + strand, within AO353_20775 at 4552.818 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.821 kb on + strand, within AO353_20775 at 4552.822 kb on - strand, within AO353_20775 at 4552.822 kb on - strand, within AO353_20775 at 4552.822 kb on - strand, within AO353_20775 at 4552.822 kb on - strand, within AO353_20775 at 4552.822 kb on - strand, within AO353_20775 at 4552.822 kb on - strand, within AO353_20775 at 4552.890 kb on + strand, within AO353_20775 at 4552.890 kb on + strand, within AO353_20775 at 4552.890 kb on + strand, within AO353_20775
Per-strain Table
Position Strand Gene LocusTag Fraction Cisplatin 0.006 mg/ml remove 4,550,523 + AO353_20755 0.36 +4.1 4,550,524 - AO353_20755 0.37 +1.8 4,550,539 + AO353_20755 0.39 +0.6 4,550,539 + AO353_20755 0.39 +0.9 4,550,539 + AO353_20755 0.39 -1.8 4,550,539 + AO353_20755 0.39 -0.2 4,550,539 + AO353_20755 0.39 -2.8 4,550,539 + AO353_20755 0.39 -2.5 4,550,539 + AO353_20755 0.39 -0.2 4,550,539 + AO353_20755 0.39 -0.2 4,550,539 + AO353_20755 0.39 -0.2 4,550,539 + AO353_20755 0.39 +0.0 4,550,540 - AO353_20755 0.39 -1.8 4,550,540 - AO353_20755 0.39 -1.2 4,550,540 - AO353_20755 0.39 +1.0 4,550,543 + AO353_20755 0.39 -1.5 4,550,543 + AO353_20755 0.39 +0.8 4,550,543 + AO353_20755 0.39 -0.5 4,550,543 + AO353_20755 0.39 +0.6 4,550,543 + AO353_20755 0.39 +2.1 4,550,543 + AO353_20755 0.39 +0.4 4,550,543 + AO353_20755 0.39 -1.8 4,550,543 + AO353_20755 0.39 +0.3 4,550,543 + AO353_20755 0.39 -1.8 4,550,544 - AO353_20755 0.39 -1.2 4,550,544 - AO353_20755 0.39 +2.8 4,550,544 - AO353_20755 0.39 -0.2 4,550,544 - AO353_20755 0.39 +0.2 4,550,544 - AO353_20755 0.39 -1.0 4,550,544 - AO353_20755 0.39 -0.8 4,550,544 - AO353_20755 0.39 -1.0 4,550,544 - AO353_20755 0.39 -0.5 4,550,573 - AO353_20755 0.43 -2.5 4,550,602 + AO353_20755 0.47 -0.2 4,550,602 + AO353_20755 0.47 +0.4 4,550,602 + AO353_20755 0.47 -1.1 4,550,602 + AO353_20755 0.47 -2.0 4,550,602 + AO353_20755 0.47 -2.2 4,550,602 + AO353_20755 0.47 +1.6 4,550,602 + AO353_20755 0.47 -0.7 4,550,602 + AO353_20755 0.47 +0.1 4,550,602 + AO353_20755 0.47 -0.8 4,550,602 + AO353_20755 0.47 -2.8 4,550,602 + AO353_20755 0.47 +0.4 4,550,602 + AO353_20755 0.47 +1.8 4,550,602 + AO353_20755 0.47 +1.4 4,550,602 + AO353_20755 0.47 +0.4 4,550,602 + AO353_20755 0.47 -2.2 4,550,602 + AO353_20755 0.47 -2.5 4,550,602 + AO353_20755 0.47 -1.5 4,550,602 + AO353_20755 0.47 +1.8 4,550,603 - AO353_20755 0.47 +0.5 4,550,603 - AO353_20755 0.47 -1.2 4,550,603 - AO353_20755 0.47 -2.8 4,550,603 - AO353_20755 0.47 +0.6 4,550,603 - AO353_20755 0.47 -2.8 4,550,603 - AO353_20755 0.47 -2.8 4,550,603 - AO353_20755 0.47 +0.8 4,550,603 - AO353_20755 0.47 -1.0 4,550,642 + AO353_20755 0.53 -2.5 4,550,642 + AO353_20755 0.53 -2.2 4,550,643 - AO353_20755 0.53 -2.2 4,550,643 - AO353_20755 0.53 +2.4 4,550,643 - AO353_20755 0.53 +1.2 4,550,652 + AO353_20755 0.54 -0.1 4,550,748 + AO353_20755 0.67 -0.2 4,550,748 + AO353_20755 0.67 +0.0 4,550,748 + AO353_20755 0.67 -1.2 4,550,748 + AO353_20755 0.67 +0.8 4,550,749 - AO353_20755 0.68 -1.8 4,550,749 - AO353_20755 0.68 +1.0 4,550,749 - AO353_20755 0.68 -2.8 4,550,760 + AO353_20755 0.69 +1.0 4,550,760 + AO353_20755 0.69 +0.8 4,550,760 + AO353_20755 0.69 +0.4 4,550,761 - AO353_20755 0.69 -1.2 4,550,761 - AO353_20755 0.69 -0.2 4,550,787 + AO353_20755 0.73 +3.1 4,550,788 - AO353_20755 0.73 +1.5 4,550,802 + AO353_20755 0.75 +1.8 4,550,878 + AO353_20755 0.85 -1.0 4,550,879 - AO353_20755 0.86 -1.2 4,550,935 - -1.8 4,550,946 + +4.2 4,550,946 + -1.8 4,550,946 + -0.1 4,550,946 + +2.1 4,550,946 + -2.8 4,550,946 + -0.2 4,550,946 + -2.0 4,550,946 + -0.2 4,550,946 + -1.2 4,550,947 - -1.8 4,550,947 - +0.2 4,551,021 + AO353_20760 0.12 +0.7 4,551,021 + AO353_20760 0.12 -0.5 4,551,022 - AO353_20760 0.13 -0.2 4,551,022 - AO353_20760 0.13 -1.8 4,551,022 - AO353_20760 0.13 +1.2 4,551,022 - AO353_20760 0.13 -0.2 4,551,022 - AO353_20760 0.13 -3.4 4,551,045 + AO353_20760 0.25 -1.8 4,551,045 + AO353_20760 0.25 -2.8 4,551,045 + AO353_20760 0.25 -0.2 4,551,045 + AO353_20760 0.25 -2.8 4,551,045 + AO353_20760 0.25 +0.2 4,551,046 - AO353_20760 0.26 -1.8 4,551,046 - AO353_20760 0.26 -2.2 4,551,046 - AO353_20760 0.26 -2.2 4,551,046 - AO353_20760 0.26 +1.6 4,551,118 + AO353_20760 0.65 -1.8 4,551,119 - AO353_20760 0.66 -0.2 4,551,231 + -0.6 4,551,231 + -1.2 4,551,232 - -0.2 4,551,301 - -2.2 4,551,301 - -1.2 4,551,337 + -0.5 4,551,338 - +0.6 4,551,338 - -1.0 4,551,338 - +2.0 4,551,339 + +0.4 4,551,339 + -0.2 4,551,339 + +0.8 4,551,339 + +2.6 4,551,339 + -2.0 4,551,339 + +1.1 4,551,339 + -1.8 4,551,339 + +4.0 4,551,339 + +0.4 4,551,339 + -1.2 4,551,339 + +2.4 4,551,339 + +0.4 4,551,340 - +0.3 4,551,340 - -0.2 4,551,340 - -2.5 4,551,340 - +0.6 4,551,340 - +1.0 4,551,340 - -2.2 4,551,340 - -1.2 4,551,403 - AO353_20765 0.11 -1.2 4,551,452 + AO353_20765 0.20 -0.2 4,551,453 - AO353_20765 0.20 -0.2 4,551,471 + AO353_20765 0.23 -0.2 4,551,471 + AO353_20765 0.23 +0.4 4,551,471 + AO353_20765 0.23 +1.4 4,551,471 + AO353_20765 0.23 -1.8 4,551,472 - AO353_20765 0.23 +1.4 4,551,472 - AO353_20765 0.23 -1.8 4,551,472 - AO353_20765 0.23 -2.5 4,551,472 - AO353_20765 0.23 -1.5 4,551,472 - AO353_20765 0.23 -1.8 4,551,708 + AO353_20765 0.66 -2.8 4,551,708 + AO353_20765 0.66 -0.5 4,551,708 + AO353_20765 0.66 +0.5 4,551,709 - AO353_20765 0.66 +0.8 4,551,709 - AO353_20765 0.66 -1.5 4,551,709 - AO353_20765 0.66 -1.2 4,551,733 + AO353_20765 0.71 -2.5 4,551,733 + AO353_20765 0.71 +1.6 4,551,772 + AO353_20765 0.78 -1.8 4,551,951 + -1.8 4,551,951 + +0.6 4,551,951 + -4.1 4,551,952 - +2.0 4,551,952 - -0.2 4,551,952 - -0.2 4,552,020 + -0.8 4,552,020 + -1.8 4,552,021 - -0.2 4,552,021 - -1.8 4,552,021 - -2.2 4,552,021 - -2.0 4,552,021 - +0.3 4,552,029 + -1.2 4,552,030 - -1.2 4,552,051 + -1.8 4,552,052 - -0.2 4,552,052 - -1.2 4,552,078 + AO353_20770 0.13 +0.8 4,552,078 + AO353_20770 0.13 +1.6 4,552,078 + AO353_20770 0.13 -2.5 4,552,079 - AO353_20770 0.13 -0.8 4,552,079 - AO353_20770 0.13 +0.9 4,552,079 - AO353_20770 0.13 +0.8 4,552,079 - AO353_20770 0.13 -1.2 4,552,109 + AO353_20770 0.28 +1.4 4,552,110 - AO353_20770 0.29 -0.2 4,552,110 - AO353_20770 0.29 -1.2 4,552,197 + AO353_20770 0.72 -2.2 4,552,197 + AO353_20770 0.72 +0.5 4,552,197 + AO353_20770 0.72 +0.1 4,552,198 - AO353_20770 0.73 +1.8 4,552,198 - AO353_20770 0.73 +1.9 4,552,198 - AO353_20770 0.73 +1.7 4,552,250 + -0.2 4,552,250 + -2.2 4,552,251 - -0.2 4,552,430 + -0.2 4,552,464 - -1.8 4,552,465 + +0.2 4,552,465 + +2.2 4,552,465 + -1.8 4,552,466 - -2.8 4,552,466 - +0.9 4,552,596 + AO353_20775 0.13 -1.5 4,552,596 + AO353_20775 0.13 -1.8 4,552,596 + AO353_20775 0.13 +1.5 4,552,596 + AO353_20775 0.13 -0.6 4,552,596 + AO353_20775 0.13 -1.0 4,552,596 + AO353_20775 0.13 -2.5 4,552,597 - AO353_20775 0.13 -1.2 4,552,597 - AO353_20775 0.13 -0.2 4,552,597 - AO353_20775 0.13 +1.4 4,552,597 - AO353_20775 0.13 -2.2 4,552,597 - AO353_20775 0.13 -2.0 4,552,597 - AO353_20775 0.13 -3.2 4,552,597 - AO353_20775 0.13 +1.0 4,552,641 + AO353_20775 0.20 -1.2 4,552,669 + AO353_20775 0.24 -1.2 4,552,669 + AO353_20775 0.24 -2.2 4,552,669 + AO353_20775 0.24 +2.2 4,552,670 - AO353_20775 0.24 -0.2 4,552,670 - AO353_20775 0.24 -0.2 4,552,670 - AO353_20775 0.24 -2.8 4,552,818 + AO353_20775 0.45 -0.8 4,552,818 + AO353_20775 0.45 -0.2 4,552,821 + AO353_20775 0.45 -2.8 4,552,821 + AO353_20775 0.45 +0.8 4,552,821 + AO353_20775 0.45 -3.5 4,552,821 + AO353_20775 0.45 +0.4 4,552,821 + AO353_20775 0.45 -1.8 4,552,821 + AO353_20775 0.45 -2.2 4,552,821 + AO353_20775 0.45 -2.2 4,552,821 + AO353_20775 0.45 +0.2 4,552,822 - AO353_20775 0.45 -2.2 4,552,822 - AO353_20775 0.45 +0.2 4,552,822 - AO353_20775 0.45 -1.8 4,552,822 - AO353_20775 0.45 -0.2 4,552,822 - AO353_20775 0.45 -0.9 4,552,822 - AO353_20775 0.45 -1.0 4,552,890 + AO353_20775 0.55 +2.4 4,552,890 + AO353_20775 0.55 -2.2 4,552,890 + AO353_20775 0.55 +0.0
Or see this region's nucleotide sequence