Experiment: nitrite (N)
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Psest_3389 and Psest_3390 are separated by 95 nucleotides Psest_3390 and Psest_3391 are separated by 108 nucleotides Psest_3391 and Psest_3392 overlap by 4 nucleotides Psest_3392 and Psest_3393 are separated by 49 nucleotides Psest_3393 and Psest_3394 are separated by 119 nucleotides
Psest_3389: Psest_3389 - hypothetical protein, at 3,559,133 to 3,559,360
_3389
Psest_3390: Psest_3390 - FKBP-type peptidyl-prolyl cis-trans isomerases 1, at 3,559,456 to 3,560,073
_3390
Psest_3391: Psest_3391 - Uncharacterized protein conserved in bacteria, at 3,560,182 to 3,560,319
_3391
Psest_3392: Psest_3392 - Uncharacterized protein related to deoxyribodipyrimidine photolyase, at 3,560,316 to 3,561,851
_3392
Psest_3393: Psest_3393 - hypothetical protein, at 3,561,901 to 3,562,206
_3393
Psest_3394: Psest_3394 - TIGR00645 family protein, at 3,562,326 to 3,562,814
_3394
Position (kb)
3560
3561
3562 Strain fitness (log2 ratio)
-3
-2
-1
0
1
2
3 at 3559.337 kb on + strand, within Psest_3389 at 3559.337 kb on + strand, within Psest_3389 at 3559.338 kb on - strand at 3559.338 kb on - strand at 3559.338 kb on - strand at 3559.359 kb on - strand at 3559.416 kb on + strand at 3559.416 kb on + strand at 3559.416 kb on + strand at 3559.416 kb on + strand at 3559.416 kb on + strand at 3559.416 kb on + strand at 3559.417 kb on - strand at 3559.417 kb on - strand at 3559.533 kb on - strand, within Psest_3390 at 3559.533 kb on - strand, within Psest_3390 at 3559.533 kb on - strand, within Psest_3390 at 3559.553 kb on + strand, within Psest_3390 at 3559.553 kb on + strand, within Psest_3390 at 3559.553 kb on + strand, within Psest_3390 at 3559.554 kb on - strand, within Psest_3390 at 3559.702 kb on - strand, within Psest_3390 at 3559.702 kb on - strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.705 kb on + strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.706 kb on - strand, within Psest_3390 at 3559.757 kb on + strand, within Psest_3390 at 3559.758 kb on - strand, within Psest_3390 at 3560.030 kb on + strand at 3560.030 kb on + strand at 3560.030 kb on + strand at 3560.030 kb on + strand at 3560.288 kb on + strand, within Psest_3391 at 3560.288 kb on + strand, within Psest_3391 at 3560.289 kb on - strand, within Psest_3391 at 3560.289 kb on - strand, within Psest_3391 at 3560.404 kb on - strand at 3560.404 kb on - strand at 3560.476 kb on + strand, within Psest_3392 at 3560.476 kb on + strand, within Psest_3392 at 3560.476 kb on + strand, within Psest_3392 at 3560.527 kb on + strand, within Psest_3392 at 3560.527 kb on + strand, within Psest_3392 at 3560.527 kb on + strand, within Psest_3392 at 3560.566 kb on + strand, within Psest_3392 at 3560.566 kb on + strand, within Psest_3392 at 3560.566 kb on + strand, within Psest_3392 at 3560.566 kb on + strand, within Psest_3392 at 3560.584 kb on + strand, within Psest_3392 at 3560.671 kb on + strand, within Psest_3392 at 3560.671 kb on + strand, within Psest_3392 at 3560.671 kb on + strand, within Psest_3392 at 3560.672 kb on - strand, within Psest_3392 at 3560.672 kb on - strand, within Psest_3392 at 3560.672 kb on - strand, within Psest_3392 at 3560.672 kb on - strand, within Psest_3392 at 3560.672 kb on - strand, within Psest_3392 at 3560.672 kb on - strand, within Psest_3392 at 3560.684 kb on - strand, within Psest_3392 at 3560.721 kb on + strand, within Psest_3392 at 3560.721 kb on + strand, within Psest_3392 at 3560.721 kb on + strand, within Psest_3392 at 3560.721 kb on + strand, within Psest_3392 at 3560.722 kb on - strand, within Psest_3392 at 3560.722 kb on - strand, within Psest_3392 at 3560.756 kb on + strand, within Psest_3392 at 3560.767 kb on + strand, within Psest_3392 at 3560.768 kb on - strand, within Psest_3392 at 3560.834 kb on - strand, within Psest_3392 at 3560.834 kb on - strand, within Psest_3392 at 3560.856 kb on - strand, within Psest_3392 at 3560.902 kb on + strand, within Psest_3392 at 3560.902 kb on + strand, within Psest_3392 at 3560.903 kb on - strand, within Psest_3392 at 3560.903 kb on - strand, within Psest_3392 at 3560.917 kb on + strand, within Psest_3392 at 3560.917 kb on + strand, within Psest_3392 at 3560.917 kb on + strand, within Psest_3392 at 3560.918 kb on - strand, within Psest_3392 at 3561.364 kb on - strand, within Psest_3392 at 3561.394 kb on + strand, within Psest_3392 at 3561.486 kb on - strand, within Psest_3392 at 3561.634 kb on + strand, within Psest_3392 at 3561.634 kb on + strand, within Psest_3392 at 3561.635 kb on - strand, within Psest_3392 at 3561.809 kb on + strand at 3561.809 kb on + strand at 3561.809 kb on + strand at 3561.810 kb on - strand at 3561.810 kb on - strand at 3561.810 kb on - strand at 3561.810 kb on - strand at 3562.090 kb on - strand, within Psest_3393 at 3562.109 kb on + strand, within Psest_3393 at 3562.109 kb on + strand, within Psest_3393 at 3562.109 kb on + strand, within Psest_3393 at 3562.109 kb on + strand, within Psest_3393 at 3562.110 kb on - strand, within Psest_3393 at 3562.110 kb on - strand, within Psest_3393 at 3562.110 kb on - strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.124 kb on + strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.125 kb on - strand, within Psest_3393 at 3562.164 kb on + strand, within Psest_3393 at 3562.165 kb on - strand, within Psest_3393 at 3562.165 kb on - strand, within Psest_3393 at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.202 kb on + strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.203 kb on - strand at 3562.287 kb on + strand at 3562.351 kb on + strand at 3562.351 kb on + strand at 3562.352 kb on - strand at 3562.352 kb on - strand at 3562.375 kb on - strand, within Psest_3394 at 3562.400 kb on - strand, within Psest_3394 at 3562.400 kb on - strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.406 kb on + strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.407 kb on - strand, within Psest_3394 at 3562.449 kb on + strand, within Psest_3394 at 3562.449 kb on + strand, within Psest_3394 at 3562.449 kb on + strand, within Psest_3394 at 3562.756 kb on + strand, within Psest_3394 at 3562.756 kb on + strand, within Psest_3394 at 3562.756 kb on + strand, within Psest_3394 at 3562.756 kb on + strand, within Psest_3394 at 3562.756 kb on + strand, within Psest_3394 at 3562.756 kb on + strand, within Psest_3394 at 3562.757 kb on - strand, within Psest_3394 at 3562.757 kb on - strand, within Psest_3394 at 3562.757 kb on - strand, within Psest_3394 at 3562.757 kb on - strand, within Psest_3394 at 3562.757 kb on - strand, within Psest_3394 at 3562.786 kb on + strand at 3562.786 kb on + strand at 3562.787 kb on - strand at 3562.787 kb on - strand at 3562.787 kb on - strand at 3562.787 kb on - strand at 3562.787 kb on - strand at 3562.850 kb on + strand at 3562.850 kb on + strand at 3562.851 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction nitrite (N) remove 3,559,337 + Psest_3389 0.89 +0.5 3,559,337 + Psest_3389 0.89 +0.9 3,559,338 - +0.5 3,559,338 - -0.2 3,559,338 - -0.9 3,559,359 - +0.7 3,559,416 + +0.3 3,559,416 + -0.8 3,559,416 + -0.9 3,559,416 + -0.4 3,559,416 + -0.1 3,559,416 + -0.1 3,559,417 - +0.5 3,559,417 - -0.1 3,559,533 - Psest_3390 0.12 +3.7 3,559,533 - Psest_3390 0.12 +0.2 3,559,533 - Psest_3390 0.12 +0.6 3,559,553 + Psest_3390 0.16 +0.7 3,559,553 + Psest_3390 0.16 -0.2 3,559,553 + Psest_3390 0.16 -0.5 3,559,554 - Psest_3390 0.16 +0.4 3,559,702 - Psest_3390 0.40 -0.7 3,559,702 - Psest_3390 0.40 -2.6 3,559,705 + Psest_3390 0.40 -0.4 3,559,705 + Psest_3390 0.40 +0.0 3,559,705 + Psest_3390 0.40 -1.0 3,559,705 + Psest_3390 0.40 -0.2 3,559,705 + Psest_3390 0.40 -0.6 3,559,705 + Psest_3390 0.40 +0.0 3,559,705 + Psest_3390 0.40 -0.2 3,559,705 + Psest_3390 0.40 +3.3 3,559,705 + Psest_3390 0.40 -0.7 3,559,705 + Psest_3390 0.40 -0.2 3,559,705 + Psest_3390 0.40 -0.2 3,559,705 + Psest_3390 0.40 -0.3 3,559,705 + Psest_3390 0.40 +0.5 3,559,705 + Psest_3390 0.40 -2.3 3,559,706 - Psest_3390 0.40 +0.9 3,559,706 - Psest_3390 0.40 +1.2 3,559,706 - Psest_3390 0.40 +0.1 3,559,706 - Psest_3390 0.40 +0.7 3,559,706 - Psest_3390 0.40 -0.1 3,559,706 - Psest_3390 0.40 +0.3 3,559,706 - Psest_3390 0.40 +0.8 3,559,706 - Psest_3390 0.40 -0.5 3,559,757 + Psest_3390 0.49 -0.4 3,559,758 - Psest_3390 0.49 +0.4 3,560,030 + +0.1 3,560,030 + -0.9 3,560,030 + -0.1 3,560,030 + -0.7 3,560,288 + Psest_3391 0.77 -0.8 3,560,288 + Psest_3391 0.77 +0.2 3,560,289 - Psest_3391 0.78 +0.0 3,560,289 - Psest_3391 0.78 -0.5 3,560,404 - -0.7 3,560,404 - -0.8 3,560,476 + Psest_3392 0.10 -0.2 3,560,476 + Psest_3392 0.10 -0.7 3,560,476 + Psest_3392 0.10 +0.4 3,560,527 + Psest_3392 0.14 -0.6 3,560,527 + Psest_3392 0.14 -0.1 3,560,527 + Psest_3392 0.14 +0.0 3,560,566 + Psest_3392 0.16 -0.0 3,560,566 + Psest_3392 0.16 +0.0 3,560,566 + Psest_3392 0.16 -0.4 3,560,566 + Psest_3392 0.16 -1.3 3,560,584 + Psest_3392 0.17 +0.0 3,560,671 + Psest_3392 0.23 -0.3 3,560,671 + Psest_3392 0.23 -1.7 3,560,671 + Psest_3392 0.23 -0.0 3,560,672 - Psest_3392 0.23 +0.3 3,560,672 - Psest_3392 0.23 -0.1 3,560,672 - Psest_3392 0.23 -0.4 3,560,672 - Psest_3392 0.23 +0.6 3,560,672 - Psest_3392 0.23 +0.1 3,560,672 - Psest_3392 0.23 +0.0 3,560,684 - Psest_3392 0.24 +0.3 3,560,721 + Psest_3392 0.26 -0.1 3,560,721 + Psest_3392 0.26 -0.1 3,560,721 + Psest_3392 0.26 -1.5 3,560,721 + Psest_3392 0.26 -0.4 3,560,722 - Psest_3392 0.26 -0.4 3,560,722 - Psest_3392 0.26 -0.7 3,560,756 + Psest_3392 0.29 -1.0 3,560,767 + Psest_3392 0.29 -1.0 3,560,768 - Psest_3392 0.29 -0.6 3,560,834 - Psest_3392 0.34 -0.2 3,560,834 - Psest_3392 0.34 -2.6 3,560,856 - Psest_3392 0.35 -0.5 3,560,902 + Psest_3392 0.38 -0.1 3,560,902 + Psest_3392 0.38 -0.3 3,560,903 - Psest_3392 0.38 -0.7 3,560,903 - Psest_3392 0.38 +0.0 3,560,917 + Psest_3392 0.39 -1.2 3,560,917 + Psest_3392 0.39 -1.0 3,560,917 + Psest_3392 0.39 +1.0 3,560,918 - Psest_3392 0.39 -0.8 3,561,364 - Psest_3392 0.68 -0.7 3,561,394 + Psest_3392 0.70 -0.2 3,561,486 - Psest_3392 0.76 -0.9 3,561,634 + Psest_3392 0.86 -0.5 3,561,634 + Psest_3392 0.86 -1.2 3,561,635 - Psest_3392 0.86 -0.5 3,561,809 + +0.5 3,561,809 + +0.8 3,561,809 + +0.6 3,561,810 - +0.2 3,561,810 - -2.3 3,561,810 - +0.3 3,561,810 - +0.8 3,562,090 - Psest_3393 0.62 +0.0 3,562,109 + Psest_3393 0.68 +0.2 3,562,109 + Psest_3393 0.68 +0.3 3,562,109 + Psest_3393 0.68 -0.4 3,562,109 + Psest_3393 0.68 +0.3 3,562,110 - Psest_3393 0.68 +0.2 3,562,110 - Psest_3393 0.68 -1.1 3,562,110 - Psest_3393 0.68 +0.3 3,562,124 + Psest_3393 0.73 -0.7 3,562,124 + Psest_3393 0.73 +0.1 3,562,124 + Psest_3393 0.73 +0.8 3,562,124 + Psest_3393 0.73 +0.5 3,562,124 + Psest_3393 0.73 +0.7 3,562,124 + Psest_3393 0.73 +1.1 3,562,124 + Psest_3393 0.73 +0.8 3,562,124 + Psest_3393 0.73 -0.2 3,562,124 + Psest_3393 0.73 -1.4 3,562,124 + Psest_3393 0.73 -0.1 3,562,124 + Psest_3393 0.73 -0.1 3,562,124 + Psest_3393 0.73 -0.2 3,562,125 - Psest_3393 0.73 -1.5 3,562,125 - Psest_3393 0.73 +0.5 3,562,125 - Psest_3393 0.73 -0.4 3,562,125 - Psest_3393 0.73 -0.0 3,562,125 - Psest_3393 0.73 +0.2 3,562,125 - Psest_3393 0.73 -1.6 3,562,125 - Psest_3393 0.73 -0.6 3,562,125 - Psest_3393 0.73 -0.8 3,562,125 - Psest_3393 0.73 +0.2 3,562,125 - Psest_3393 0.73 +0.3 3,562,125 - Psest_3393 0.73 +0.2 3,562,125 - Psest_3393 0.73 +0.8 3,562,125 - Psest_3393 0.73 -1.1 3,562,125 - Psest_3393 0.73 +0.0 3,562,125 - Psest_3393 0.73 +0.5 3,562,125 - Psest_3393 0.73 +0.0 3,562,125 - Psest_3393 0.73 -0.1 3,562,164 + Psest_3393 0.86 -1.0 3,562,165 - Psest_3393 0.86 -0.2 3,562,165 - Psest_3393 0.86 -0.9 3,562,202 + -0.1 3,562,202 + +0.1 3,562,202 + +0.1 3,562,202 + -0.7 3,562,202 + +1.8 3,562,202 + -1.7 3,562,202 + -0.1 3,562,202 + -1.0 3,562,202 + +0.3 3,562,202 + -0.8 3,562,202 + -0.7 3,562,202 + -0.0 3,562,202 + -0.6 3,562,202 + +1.6 3,562,202 + -0.1 3,562,202 + -0.2 3,562,202 + +0.9 3,562,203 - -2.0 3,562,203 - +0.6 3,562,203 - +0.1 3,562,203 - -1.7 3,562,203 - -0.1 3,562,203 - -0.0 3,562,203 - +0.1 3,562,203 - +2.3 3,562,203 - -0.2 3,562,203 - -0.5 3,562,203 - +0.4 3,562,203 - +1.3 3,562,203 - +0.6 3,562,203 - +0.4 3,562,203 - +0.5 3,562,203 - +1.3 3,562,203 - -0.4 3,562,203 - +0.1 3,562,203 - +0.1 3,562,203 - -1.9 3,562,287 + -1.4 3,562,351 + -0.9 3,562,351 + +0.3 3,562,352 - -0.7 3,562,352 - +1.3 3,562,375 - Psest_3394 0.10 +0.7 3,562,400 - Psest_3394 0.15 -0.1 3,562,400 - Psest_3394 0.15 -1.6 3,562,406 + Psest_3394 0.16 +0.3 3,562,406 + Psest_3394 0.16 -0.6 3,562,406 + Psest_3394 0.16 -0.3 3,562,406 + Psest_3394 0.16 -0.7 3,562,406 + Psest_3394 0.16 -0.7 3,562,406 + Psest_3394 0.16 +0.6 3,562,406 + Psest_3394 0.16 -0.9 3,562,406 + Psest_3394 0.16 -3.1 3,562,406 + Psest_3394 0.16 -0.3 3,562,406 + Psest_3394 0.16 +0.8 3,562,406 + Psest_3394 0.16 +0.3 3,562,406 + Psest_3394 0.16 +2.6 3,562,407 - Psest_3394 0.17 -0.9 3,562,407 - Psest_3394 0.17 -0.2 3,562,407 - Psest_3394 0.17 -0.9 3,562,407 - Psest_3394 0.17 -0.1 3,562,407 - Psest_3394 0.17 -0.9 3,562,407 - Psest_3394 0.17 +1.9 3,562,407 - Psest_3394 0.17 -0.9 3,562,407 - Psest_3394 0.17 +0.9 3,562,407 - Psest_3394 0.17 +1.1 3,562,407 - Psest_3394 0.17 +0.3 3,562,407 - Psest_3394 0.17 -0.6 3,562,407 - Psest_3394 0.17 -1.5 3,562,407 - Psest_3394 0.17 +0.5 3,562,407 - Psest_3394 0.17 +0.1 3,562,449 + Psest_3394 0.25 -0.3 3,562,449 + Psest_3394 0.25 -0.1 3,562,449 + Psest_3394 0.25 +1.3 3,562,756 + Psest_3394 0.88 +0.3 3,562,756 + Psest_3394 0.88 -0.7 3,562,756 + Psest_3394 0.88 +0.3 3,562,756 + Psest_3394 0.88 -0.4 3,562,756 + Psest_3394 0.88 -0.0 3,562,756 + Psest_3394 0.88 +2.8 3,562,757 - Psest_3394 0.88 -0.9 3,562,757 - Psest_3394 0.88 -0.2 3,562,757 - Psest_3394 0.88 +1.0 3,562,757 - Psest_3394 0.88 +0.2 3,562,757 - Psest_3394 0.88 +0.4 3,562,786 + +0.4 3,562,786 + +0.3 3,562,787 - -0.0 3,562,787 - +1.5 3,562,787 - +0.1 3,562,787 - -0.2 3,562,787 - +1.1 3,562,850 + -2.0 3,562,850 + -0.4 3,562,851 - +0.3
Or see this region's nucleotide sequence