Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2276

Experiment: L-Aspartic Acid (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2274c and Rv2274A are separated by 33 nucleotidesRv2274A and Rv2275 overlap by 205 nucleotidesRv2275 and Rv2276 overlap by 4 nucleotidesRv2276 and Rv2277c are separated by 184 nucleotides Rv2274c: Rv2274c - Possible toxin MazF8, at 2,546,488 to 2,546,805 Rv2274c Rv2274A: Rv2274A - Possible antitoxin MazE8, at 2,546,839 to 2,547,087 Rv2274A Rv2275: Rv2275 - Conserved hypothetical protein, at 2,546,883 to 2,547,752 Rv2275 Rv2276: Rv2276 - Cytochrome P450 121 Cyp121, at 2,547,749 to 2,548,939 Rv2276 Rv2277c: Rv2277c - Possible glycerolphosphodiesterase, at 2,549,124 to 2,550,029 Rv2277c Position (kb) 2547 2548 2549Strain fitness (log2 ratio) -1 0 1at 2546.779 kb on - strandat 2546.800 kb on - strandat 2547.160 kb on - strand, within Rv2275at 2547.567 kb on + strand, within Rv2275at 2547.568 kb on - strand, within Rv2275at 2547.672 kb on + strandat 2548.234 kb on + strand, within Rv2276at 2548.497 kb on + strand, within Rv2276at 2549.512 kb on - strand, within Rv2277cat 2549.598 kb on + strand, within Rv2277cat 2549.598 kb on + strand, within Rv2277cat 2549.800 kb on + strand, within Rv2277cat 2549.877 kb on - strand, within Rv2277c

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Per-strain Table

Position Strand Gene LocusTag Fraction L-Aspartic Acid (C)
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2,546,779 - -0.2
2,546,800 - +1.0
2,547,160 - Rv2275 0.32 +0.6
2,547,567 + Rv2275 0.79 +0.8
2,547,568 - Rv2275 0.79 -0.1
2,547,672 + -1.4
2,548,234 + Rv2276 0.41 -1.7
2,548,497 + Rv2276 0.63 -0.2
2,549,512 - Rv2277c 0.43 -0.7
2,549,598 + Rv2277c 0.52 +0.8
2,549,598 + Rv2277c 0.52 +0.6
2,549,800 + Rv2277c 0.75 -0.3
2,549,877 - Rv2277c 0.83 -0.0

Or see this region's nucleotide sequence