Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1010

Experiment: L-Aspartic Acid (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1009 and Rv1010 overlap by 28 nucleotidesRv1010 and Rv1011 are separated by 85 nucleotides Rv1009: Rv1009 - Probable resuscitation-promoting factor RpfB, at 1,128,091 to 1,129,179 Rv1009 Rv1010: Rv1010 - Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase), at 1,129,152 to 1,130,105 Rv1010 Rv1011: Rv1011 - Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase), at 1,130,191 to 1,131,111 Rv1011 Position (kb) 1129 1130 1131Strain fitness (log2 ratio) -1 0 1at 1128.277 kb on + strand, within Rv1009at 1128.278 kb on - strand, within Rv1009at 1128.369 kb on + strand, within Rv1009at 1129.006 kb on + strand, within Rv1009at 1129.006 kb on + strand, within Rv1009at 1129.006 kb on + strand, within Rv1009at 1129.006 kb on + strand, within Rv1009at 1129.061 kb on - strand, within Rv1009at 1129.151 kb on + strandat 1129.561 kb on - strand, within Rv1010at 1129.683 kb on + strand, within Rv1010at 1129.701 kb on - strand, within Rv1010at 1130.143 kb on + strandat 1130.144 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction L-Aspartic Acid (C)
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1,128,277 + Rv1009 0.17 -0.2
1,128,278 - Rv1009 0.17 +0.2
1,128,369 + Rv1009 0.26 -0.5
1,129,006 + Rv1009 0.84 -0.9
1,129,006 + Rv1009 0.84 +1.6
1,129,006 + Rv1009 0.84 -0.5
1,129,006 + Rv1009 0.84 -0.4
1,129,061 - Rv1009 0.89 -1.5
1,129,151 + +0.3
1,129,561 - Rv1010 0.43 -0.5
1,129,683 + Rv1010 0.56 -0.7
1,129,701 - Rv1010 0.58 +1.0
1,130,143 + +0.2
1,130,144 - -0.6

Or see this region's nucleotide sequence