Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3374

Experiment: propionate (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3372 and Rv3373 are separated by 236 nucleotidesRv3373 and Rv3374 are separated by 0 nucleotidesRv3374 and Rv3375 are separated by 4 nucleotides Rv3372: Rv3372 - Trehalose 6-phosphate phosphatase OtsB2 (trehalose-phosphatase) (TPP), at 3,786,314 to 3,787,489 Rv3372 Rv3373: Rv3373 - Probable enoyl-CoA hydratase EchA18 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 3,787,726 to 3,788,367 Rv3373 Rv3374: Rv3374 - Probable enoyl-CoA hydratase (fragment) EchA18.1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 3,788,368 to 3,788,616 Rv3374 Rv3375: Rv3375 - Probable amidase AmiD (acylamidase) (acylase), at 3,788,621 to 3,790,048 Rv3375 Position (kb) 3788 3789Strain fitness (log2 ratio) -2 -1 0 1at 3787.513 kb on - strandat 3787.513 kb on - strandat 3787.662 kb on + strandat 3787.663 kb on - strandat 3788.545 kb on + strand, within Rv3374at 3788.546 kb on - strand, within Rv3374at 3788.789 kb on + strand, within Rv3375at 3788.884 kb on - strand, within Rv3375at 3789.048 kb on - strand, within Rv3375at 3789.048 kb on - strand, within Rv3375at 3789.359 kb on - strand, within Rv3375

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Per-strain Table

Position Strand Gene LocusTag Fraction propionate (C)
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3,787,513 - -0.1
3,787,513 - +0.2
3,787,662 + -1.4
3,787,663 - -0.8
3,788,545 + Rv3374 0.71 -0.2
3,788,546 - Rv3374 0.71 -1.8
3,788,789 + Rv3375 0.12 -0.7
3,788,884 - Rv3375 0.18 -1.9
3,789,048 - Rv3375 0.30 -0.8
3,789,048 - Rv3375 0.30 +0.2
3,789,359 - Rv3375 0.52 +0.6

Or see this region's nucleotide sequence