Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2064

Experiment: propionate (C)

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2062c and Rv2063 are separated by 77 nucleotidesRv2063 and Rv2063A overlap by 8 nucleotidesRv2063A and Rv2064 overlap by 17 nucleotidesRv2064 and Rv2065 are separated by 9 nucleotidesRv2065 and Rv2066 overlap by 4 nucleotides Rv2062c: Rv2062c - Cobalamin biosynthesis protein CobN, at 2,317,169 to 2,320,753 Rv2062c Rv2063: Rv2063 - Antitoxin MazE7, at 2,320,831 to 2,321,064 Rv2063 Rv2063A: Rv2063A - Possible toxin MazF7, at 2,321,057 to 2,321,467 Rv2063A Rv2064: Rv2064 - Precorrin-3B synthase CobG, at 2,321,451 to 2,322,542 Rv2064 Rv2065: Rv2065 - Precorrin-8X methylmutase CobH (aka precorrin isomerase), at 2,322,552 to 2,323,178 Rv2065 Rv2066: Rv2066 - Probable bifunctional protein, CobI-COBJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase, at 2,323,175 to 2,324,701 Rv2066 Position (kb) 2321 2322 2323Strain fitness (log2 ratio) -2 -1 0 1at 2320.824 kb on + strandat 2321.163 kb on + strand, within Rv2063Aat 2321.163 kb on + strand, within Rv2063Aat 2321.263 kb on - strand, within Rv2063Aat 2321.729 kb on + strand, within Rv2064at 2322.041 kb on - strand, within Rv2064at 2322.566 kb on - strandat 2322.566 kb on - strandat 2322.566 kb on - strandat 2322.949 kb on + strand, within Rv2065at 2322.950 kb on - strand, within Rv2065at 2323.098 kb on + strand, within Rv2065at 2323.099 kb on - strand, within Rv2065at 2323.281 kb on - strandat 2323.331 kb on + strand, within Rv2066at 2323.331 kb on + strand, within Rv2066at 2323.431 kb on - strand, within Rv2066at 2323.431 kb on - strand, within Rv2066at 2323.514 kb on + strand, within Rv2066at 2323.515 kb on - strand, within Rv2066at 2323.515 kb on - strand, within Rv2066at 2323.515 kb on - strand, within Rv2066at 2323.523 kb on + strand, within Rv2066at 2323.523 kb on + strand, within Rv2066at 2323.523 kb on + strand, within Rv2066at 2323.524 kb on - strand, within Rv2066at 2323.524 kb on - strand, within Rv2066at 2323.524 kb on - strand, within Rv2066

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Per-strain Table

Position Strand Gene LocusTag Fraction propionate (C)
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2,320,824 + +0.8
2,321,163 + Rv2063A 0.26 -0.3
2,321,163 + Rv2063A 0.26 -0.3
2,321,263 - Rv2063A 0.50 -0.1
2,321,729 + Rv2064 0.25 -1.2
2,322,041 - Rv2064 0.54 +0.8
2,322,566 - +0.1
2,322,566 - +0.6
2,322,566 - +0.5
2,322,949 + Rv2065 0.63 +0.6
2,322,950 - Rv2065 0.63 -0.2
2,323,098 + Rv2065 0.87 +0.1
2,323,099 - Rv2065 0.87 -0.9
2,323,281 - +0.0
2,323,331 + Rv2066 0.10 +0.8
2,323,331 + Rv2066 0.10 -0.1
2,323,431 - Rv2066 0.17 +0.2
2,323,431 - Rv2066 0.17 -0.1
2,323,514 + Rv2066 0.22 +0.1
2,323,515 - Rv2066 0.22 +1.1
2,323,515 - Rv2066 0.22 -0.3
2,323,515 - Rv2066 0.22 -0.7
2,323,523 + Rv2066 0.23 +0.8
2,323,523 + Rv2066 0.23 +0.8
2,323,523 + Rv2066 0.23 -0.2
2,323,524 - Rv2066 0.23 -1.9
2,323,524 - Rv2066 0.23 +0.7
2,323,524 - Rv2066 0.23 -0.0

Or see this region's nucleotide sequence