Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2336

Experiment: 7H9 with Clofazimine 0.45 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2335 and Rv2336 are separated by 415 nucleotidesRv2336 and Rv2337c are separated by 63 nucleotides Rv2335: Rv2335 - Probable serine acetyltransferase CysE (sat), at 2,609,732 to 2,610,421 Rv2335 Rv2336: Rv2336 - Hypothetical protein, at 2,610,837 to 2,611,805 Rv2336 Rv2337c: Rv2337c - Hypothetical protein, at 2,611,869 to 2,612,987 Rv2337c Position (kb) 2610 2611 2612Strain fitness (log2 ratio) -1 0 1 2 3at 2609.928 kb on + strand, within Rv2335at 2609.929 kb on - strand, within Rv2335at 2609.929 kb on - strand, within Rv2335at 2609.932 kb on + strand, within Rv2335at 2610.427 kb on + strandat 2610.486 kb on + strandat 2610.574 kb on + strandat 2610.574 kb on + strandat 2610.770 kb on + strandat 2610.771 kb on - strandat 2610.783 kb on - strandat 2611.010 kb on - strand, within Rv2336at 2611.010 kb on - strand, within Rv2336at 2611.010 kb on - strand, within Rv2336at 2611.078 kb on - strand, within Rv2336at 2611.078 kb on - strand, within Rv2336at 2611.099 kb on - strand, within Rv2336at 2611.196 kb on - strand, within Rv2336at 2611.197 kb on + strand, within Rv2336at 2611.198 kb on - strand, within Rv2336at 2611.515 kb on + strand, within Rv2336at 2611.728 kb on + strandat 2611.919 kb on - strandat 2611.924 kb on + strandat 2612.124 kb on + strand, within Rv2337cat 2612.124 kb on + strand, within Rv2337cat 2612.125 kb on - strand, within Rv2337cat 2612.125 kb on - strand, within Rv2337cat 2612.125 kb on - strand, within Rv2337cat 2612.239 kb on + strand, within Rv2337cat 2612.240 kb on - strand, within Rv2337cat 2612.430 kb on + strand, within Rv2337cat 2612.430 kb on + strand, within Rv2337cat 2612.430 kb on + strand, within Rv2337cat 2612.430 kb on + strand, within Rv2337cat 2612.431 kb on - strand, within Rv2337c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.45 ug/mL
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2,609,928 + Rv2335 0.28 -0.6
2,609,929 - Rv2335 0.29 -1.4
2,609,929 - Rv2335 0.29 -0.5
2,609,932 + Rv2335 0.29 -0.7
2,610,427 + -0.1
2,610,486 + +0.1
2,610,574 + -0.2
2,610,574 + -0.2
2,610,770 + -0.7
2,610,771 - -0.0
2,610,783 - +0.1
2,611,010 - Rv2336 0.18 +0.2
2,611,010 - Rv2336 0.18 +2.8
2,611,010 - Rv2336 0.18 +0.4
2,611,078 - Rv2336 0.25 -0.1
2,611,078 - Rv2336 0.25 +0.2
2,611,099 - Rv2336 0.27 +1.2
2,611,196 - Rv2336 0.37 +0.8
2,611,197 + Rv2336 0.37 -0.2
2,611,198 - Rv2336 0.37 +0.1
2,611,515 + Rv2336 0.70 -0.5
2,611,728 + -0.7
2,611,919 - +0.1
2,611,924 + +0.4
2,612,124 + Rv2337c 0.23 +0.4
2,612,124 + Rv2337c 0.23 +0.5
2,612,125 - Rv2337c 0.23 +0.1
2,612,125 - Rv2337c 0.23 -0.7
2,612,125 - Rv2337c 0.23 -0.3
2,612,239 + Rv2337c 0.33 -1.0
2,612,240 - Rv2337c 0.33 -0.1
2,612,430 + Rv2337c 0.50 -1.7
2,612,430 + Rv2337c 0.50 -0.4
2,612,430 + Rv2337c 0.50 -0.2
2,612,430 + Rv2337c 0.50 +0.4
2,612,431 - Rv2337c 0.50 +0.4

Or see this region's nucleotide sequence