Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0590A

Experiment: 7H9 with Clofazimine 0.45 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0589 and Rv0590 overlap by 4 nucleotidesRv0590 and Rv0590A overlap by 52 nucleotidesRv0590A and Rv0591 overlap by 4 nucleotides Rv0589: Rv0589 - Mce-family protein Mce2A, at 686,821 to 688,035 Rv0589 Rv0590: Rv0590 - Mce-family protein Mce2B, at 688,032 to 688,859 Rv0590 Rv0590A: Rv0590A - Mce-family related protein, at 688,808 to 689,062 Rv0590A Rv0591: Rv0591 - Mce-family protein Mce2C, at 689,059 to 690,504 Rv0591 Position (kb) 688 689 690Strain fitness (log2 ratio) -1 0 1at 687.991 kb on + strandat 687.991 kb on + strandat 688.235 kb on - strand, within Rv0590at 688.235 kb on - strand, within Rv0590at 688.937 kb on + strand, within Rv0590Aat 688.938 kb on - strand, within Rv0590Aat 689.011 kb on - strand, within Rv0590Aat 689.178 kb on + strandat 689.183 kb on - strandat 689.183 kb on - strandat 689.448 kb on + strand, within Rv0591

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.45 ug/mL
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687,991 + +0.4
687,991 + +0.1
688,235 - Rv0590 0.25 +0.1
688,235 - Rv0590 0.25 +0.1
688,937 + Rv0590A 0.51 -1.1
688,938 - Rv0590A 0.51 -0.5
689,011 - Rv0590A 0.80 -0.9
689,178 + -0.3
689,183 - -0.2
689,183 - -0.1
689,448 + Rv0591 0.27 +0.2

Or see this region's nucleotide sequence