Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0556

Experiment: 7H9 with Clofazimine 0.45 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0555 and Rv0556 overlap by 4 nucleotidesRv0556 and Rv0557 are separated by 61 nucleotides Rv0555: Rv0555 - Probable bifunctional menaquinone biosynthesis protein MenD : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC synthase) + 2-oxoglutarate decarboxylase (alpha-ketoglutarate decarboxylase) (KDC), at 646,298 to 647,962 Rv0555 Rv0556: Rv0556 - Probable conserved transmembrane protein, at 647,959 to 648,474 Rv0556 Rv0557: Rv0557 - Mannosyltransferase MgtA, at 648,536 to 649,672 Rv0557 Position (kb) 647 648 649Strain fitness (log2 ratio) -1 0 1at 648.417 kb on - strand, within Rv0556at 648.496 kb on - strandat 648.496 kb on - strandat 649.464 kb on + strand, within Rv0557

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.45 ug/mL
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648,417 - Rv0556 0.89 -0.9
648,496 - -0.5
648,496 - -0.2
649,464 + Rv0557 0.82 -0.4

Or see this region's nucleotide sequence