Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3575c

Experiment: 7H9 with Clofazimine 0.45 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3573c and Rv3574 are separated by 271 nucleotidesRv3574 and Rv3575c are separated by 5 nucleotidesRv3575c and Rv3576 are separated by 189 nucleotides Rv3573c: Rv3573c - Probable acyl-CoA dehydrogenase FadE34, at 4,014,077 to 4,016,212 Rv3573c Rv3574: Rv3574 - Transcriptional regulatory protein KstR (probably TetR-family), at 4,016,484 to 4,017,083 Rv3574 Rv3575c: Rv3575c - Transcriptional regulatory protein (probably LacI-family), at 4,017,089 to 4,018,168 Rv3575c Rv3576: Rv3576 - Possible conserved lipoprotein LppH, at 4,018,358 to 4,019,071 Rv3576 Position (kb) 4017 4018 4019Strain fitness (log2 ratio) -1 0 1 2at 4016.101 kb on - strandat 4016.242 kb on + strandat 4016.243 kb on - strandat 4016.243 kb on - strandat 4016.282 kb on - strandat 4016.315 kb on + strandat 4016.316 kb on - strandat 4016.316 kb on - strandat 4016.316 kb on - strandat 4016.362 kb on + strandat 4016.362 kb on + strandat 4016.363 kb on - strandat 4016.418 kb on + strandat 4016.447 kb on + strandat 4016.492 kb on - strandat 4016.644 kb on - strand, within Rv3574at 4016.835 kb on + strand, within Rv3574at 4017.082 kb on - strandat 4017.179 kb on + strandat 4017.295 kb on - strand, within Rv3575cat 4017.316 kb on - strand, within Rv3575cat 4017.430 kb on - strand, within Rv3575cat 4017.489 kb on - strand, within Rv3575cat 4017.513 kb on - strand, within Rv3575cat 4017.513 kb on - strand, within Rv3575cat 4017.624 kb on + strand, within Rv3575cat 4017.744 kb on + strand, within Rv3575cat 4017.769 kb on - strand, within Rv3575cat 4017.931 kb on - strand, within Rv3575cat 4018.014 kb on + strand, within Rv3575cat 4018.052 kb on + strand, within Rv3575cat 4018.172 kb on - strandat 4018.206 kb on - strandat 4018.322 kb on + strandat 4018.322 kb on + strandat 4018.323 kb on - strandat 4018.787 kb on + strand, within Rv3576at 4018.788 kb on - strand, within Rv3576at 4018.909 kb on + strand, within Rv3576at 4018.982 kb on - strand, within Rv3576at 4019.006 kb on - strandat 4019.117 kb on + strandat 4019.117 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.45 ug/mL
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4,016,101 - -0.1
4,016,242 + -1.5
4,016,243 - -0.4
4,016,243 - -0.4
4,016,282 - -0.2
4,016,315 + -0.5
4,016,316 - +0.0
4,016,316 - -0.2
4,016,316 - +1.5
4,016,362 + -0.8
4,016,362 + +1.7
4,016,363 - +0.2
4,016,418 + -1.3
4,016,447 + -0.9
4,016,492 - +0.8
4,016,644 - Rv3574 0.27 +0.1
4,016,835 + Rv3574 0.58 +2.7
4,017,082 - -0.1
4,017,179 + +0.3
4,017,295 - Rv3575c 0.19 -0.3
4,017,316 - Rv3575c 0.21 +0.0
4,017,430 - Rv3575c 0.32 -0.3
4,017,489 - Rv3575c 0.37 -0.5
4,017,513 - Rv3575c 0.39 -0.5
4,017,513 - Rv3575c 0.39 -0.2
4,017,624 + Rv3575c 0.50 -0.4
4,017,744 + Rv3575c 0.61 -0.2
4,017,769 - Rv3575c 0.63 -0.6
4,017,931 - Rv3575c 0.78 -0.2
4,018,014 + Rv3575c 0.86 +0.7
4,018,052 + Rv3575c 0.89 -0.3
4,018,172 - -0.1
4,018,206 - -0.2
4,018,322 + -1.4
4,018,322 + +1.0
4,018,323 - -0.8
4,018,787 + Rv3576 0.60 +2.1
4,018,788 - Rv3576 0.60 +0.4
4,018,909 + Rv3576 0.77 -0.0
4,018,982 - Rv3576 0.87 -1.6
4,019,006 - +0.8
4,019,117 + +0.1
4,019,117 + +0.1

Or see this region's nucleotide sequence