Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2270

Experiment: 7H9 with Clofazimine 0.45 ug/mL

Add experiment(s):

Zoom: Pan:

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

download SVG
500 ntRv2268c and Rv2269c are separated by 12 nucleotidesRv2269c and Rv2270 are separated by 76 nucleotidesRv2270 and Rv2271 are separated by 106 nucleotidesRv2271 and Rv2272 are separated by 105 nucleotidesRv2272 and Rv2273 overlap by 4 nucleotides Rv2268c: Rv2268c - Probable cytochrome P450 128 Cyp128, at 2,542,807 to 2,544,276 Rv2268c Rv2269c: Rv2269c - Hypothetical protein, at 2,544,289 to 2,544,621 Rv2269c Rv2270: Rv2270 - Probable lipoprotein LppN, at 2,544,698 to 2,545,225 Rv2270 Rv2271: Rv2271 - Conserved hypothetical protein, at 2,545,332 to 2,545,631 Rv2271 Rv2272: Rv2272 - Probable conserved transmembrane protein, at 2,545,737 to 2,546,105 Rv2272 Rv2273: Rv2273 - Probable conserved transmembrane protein, at 2,546,102 to 2,546,431 Rv2273 Position (kb) 2544 2545 2546Strain fitness (log2 ratio) -1 0 1at 2543.833 kb on - strand, within Rv2268cat 2543.873 kb on + strand, within Rv2268cat 2543.895 kb on - strand, within Rv2268cat 2544.300 kb on + strandat 2544.371 kb on - strand, within Rv2269cat 2544.371 kb on - strand, within Rv2269cat 2544.491 kb on + strand, within Rv2269cat 2544.491 kb on + strand, within Rv2269cat 2544.545 kb on + strand, within Rv2269cat 2544.678 kb on - strandat 2544.725 kb on + strandat 2544.726 kb on - strandat 2544.726 kb on - strandat 2544.992 kb on + strand, within Rv2270at 2545.113 kb on - strand, within Rv2270at 2545.136 kb on - strand, within Rv2270at 2545.308 kb on + strandat 2545.455 kb on + strand, within Rv2271at 2545.597 kb on + strand, within Rv2271at 2545.598 kb on - strand, within Rv2271at 2545.654 kb on + strandat 2545.655 kb on - strandat 2545.655 kb on - strandat 2545.682 kb on + strandat 2546.032 kb on - strand, within Rv2272

download strain data

Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.45 ug/mL
remove
2,543,833 - Rv2268c 0.70 -0.8
2,543,873 + Rv2268c 0.73 +0.4
2,543,895 - Rv2268c 0.74 +0.9
2,544,300 + +0.4
2,544,371 - Rv2269c 0.25 -0.8
2,544,371 - Rv2269c 0.25 -1.1
2,544,491 + Rv2269c 0.61 -0.3
2,544,491 + Rv2269c 0.61 -0.1
2,544,545 + Rv2269c 0.77 -0.2
2,544,678 - -0.1
2,544,725 + +0.5
2,544,726 - -0.7
2,544,726 - -0.4
2,544,992 + Rv2270 0.56 -1.7
2,545,113 - Rv2270 0.79 -1.2
2,545,136 - Rv2270 0.83 -0.3
2,545,308 + -0.0
2,545,455 + Rv2271 0.41 +0.1
2,545,597 + Rv2271 0.88 +0.0
2,545,598 - Rv2271 0.89 -0.9
2,545,654 + -0.3
2,545,655 - -0.1
2,545,655 - +0.0
2,545,682 + -1.2
2,546,032 - Rv2272 0.80 -0.7

Or see this region's nucleotide sequence