Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2090

Experiment: 7H9 with Clofazimine 0.45 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2089c and Rv2090 are separated by 48 nucleotidesRv2090 and Rv2091c are separated by 3 nucleotidesRv2091c and Rv2092c are separated by 41 nucleotides Rv2089c: Rv2089c - Dipeptidase PepE, at 2,346,197 to 2,347,324 Rv2089c Rv2090: Rv2090 - Probable 5'-3' exonuclease, at 2,347,373 to 2,348,554 Rv2090 Rv2091c: Rv2091c - Probable membrane protein, at 2,348,558 to 2,349,292 Rv2091c Rv2092c: Rv2092c - ATP-dependent DNA helicase HelY, at 2,349,334 to 2,352,054 Rv2092c Position (kb) 2347 2348 2349Strain fitness (log2 ratio) -2 -1 0 1 2at 2347.206 kb on + strand, within Rv2089cat 2347.206 kb on + strand, within Rv2089cat 2347.293 kb on + strandat 2347.920 kb on + strand, within Rv2090at 2348.087 kb on + strand, within Rv2090at 2348.266 kb on - strand, within Rv2090at 2348.286 kb on + strand, within Rv2090at 2348.287 kb on - strand, within Rv2090at 2348.340 kb on + strand, within Rv2090at 2348.340 kb on + strand, within Rv2090at 2348.340 kb on + strand, within Rv2090at 2348.341 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.345 kb on - strand, within Rv2090at 2348.370 kb on - strand, within Rv2090at 2348.560 kb on - strandat 2348.560 kb on - strandat 2348.580 kb on + strandat 2348.580 kb on + strandat 2348.581 kb on - strandat 2348.773 kb on + strand, within Rv2091cat 2348.829 kb on - strand, within Rv2091cat 2348.919 kb on + strand, within Rv2091cat 2348.976 kb on + strand, within Rv2091cat 2348.976 kb on + strand, within Rv2091cat 2348.994 kb on + strand, within Rv2091cat 2349.012 kb on + strand, within Rv2091cat 2349.021 kb on + strand, within Rv2091cat 2349.021 kb on + strand, within Rv2091cat 2349.022 kb on - strand, within Rv2091cat 2349.135 kb on + strand, within Rv2091cat 2349.320 kb on - strandat 2349.378 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.45 ug/mL
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2,347,206 + Rv2089c 0.89 -0.2
2,347,206 + Rv2089c 0.89 +0.5
2,347,293 + -0.3
2,347,920 + Rv2090 0.46 +0.0
2,348,087 + Rv2090 0.60 -1.0
2,348,266 - Rv2090 0.76 +0.2
2,348,286 + Rv2090 0.77 -1.5
2,348,287 - Rv2090 0.77 -1.0
2,348,340 + Rv2090 0.82 -0.7
2,348,340 + Rv2090 0.82 +0.0
2,348,340 + Rv2090 0.82 -0.1
2,348,341 - Rv2090 0.82 -0.6
2,348,345 - Rv2090 0.82 -0.2
2,348,345 - Rv2090 0.82 -1.9
2,348,345 - Rv2090 0.82 -0.2
2,348,345 - Rv2090 0.82 -0.4
2,348,370 - Rv2090 0.84 -0.5
2,348,560 - -1.2
2,348,560 - +1.8
2,348,580 + -1.1
2,348,580 + -1.5
2,348,581 - +0.0
2,348,773 + Rv2091c 0.29 +0.1
2,348,829 - Rv2091c 0.37 +1.7
2,348,919 + Rv2091c 0.49 -0.5
2,348,976 + Rv2091c 0.57 -0.4
2,348,976 + Rv2091c 0.57 +0.4
2,348,994 + Rv2091c 0.59 -0.2
2,349,012 + Rv2091c 0.62 -0.2
2,349,021 + Rv2091c 0.63 -0.3
2,349,021 + Rv2091c 0.63 +0.5
2,349,022 - Rv2091c 0.63 -0.5
2,349,135 + Rv2091c 0.79 -0.3
2,349,320 - -0.1
2,349,378 + -0.2

Or see this region's nucleotide sequence