Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1803c

Experiment: 7H9 with Clofazimine 0.45 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1802 and Rv1803c are separated by 147 nucleotidesRv1803c and Rv1804c are separated by 180 nucleotidesRv1804c and Rv1805c are separated by 337 nucleotides Rv1802: Rv1802 - PPE family protein PPE30, at 2,043,384 to 2,044,775 Rv1802 Rv1803c: Rv1803c - PE-PGRS family protein PE_PGRS32, at 2,044,923 to 2,046,842 Rv1803c Rv1804c: Rv1804c - Conserved protein, at 2,047,023 to 2,047,349 Rv1804c Rv1805c: Rv1805c - Hypothetical protein, at 2,047,687 to 2,048,034 Rv1805c Position (kb) 2044 2045 2046 2047Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2044.023 kb on + strand, within Rv1802at 2044.024 kb on - strand, within Rv1802at 2044.024 kb on - strand, within Rv1802at 2044.024 kb on - strand, within Rv1802at 2044.071 kb on + strand, within Rv1802at 2044.072 kb on - strand, within Rv1802at 2044.087 kb on - strand, within Rv1802at 2044.087 kb on - strand, within Rv1802at 2044.087 kb on - strand, within Rv1802at 2044.088 kb on + strand, within Rv1802at 2044.089 kb on - strand, within Rv1802at 2044.150 kb on + strand, within Rv1802at 2044.151 kb on - strand, within Rv1802at 2044.153 kb on + strand, within Rv1802at 2044.154 kb on - strand, within Rv1802at 2044.154 kb on - strand, within Rv1802at 2044.240 kb on + strand, within Rv1802at 2044.442 kb on + strand, within Rv1802at 2044.442 kb on + strand, within Rv1802at 2044.443 kb on - strand, within Rv1802at 2044.679 kb on - strandat 2045.253 kb on + strand, within Rv1803cat 2045.254 kb on - strand, within Rv1803cat 2045.254 kb on - strand, within Rv1803cat 2045.254 kb on - strand, within Rv1803cat 2045.310 kb on - strand, within Rv1803cat 2045.319 kb on + strand, within Rv1803cat 2045.320 kb on - strand, within Rv1803cat 2045.459 kb on - strand, within Rv1803cat 2045.460 kb on + strand, within Rv1803cat 2045.460 kb on + strand, within Rv1803cat 2045.460 kb on + strand, within Rv1803cat 2045.461 kb on - strand, within Rv1803cat 2045.461 kb on - strand, within Rv1803cat 2045.585 kb on + strand, within Rv1803cat 2045.585 kb on + strand, within Rv1803cat 2045.586 kb on - strand, within Rv1803cat 2045.601 kb on - strand, within Rv1803cat 2045.611 kb on - strand, within Rv1803cat 2045.777 kb on + strand, within Rv1803cat 2045.777 kb on + strand, within Rv1803cat 2045.778 kb on - strand, within Rv1803cat 2045.778 kb on - strand, within Rv1803cat 2045.778 kb on - strand, within Rv1803cat 2045.780 kb on + strand, within Rv1803cat 2046.010 kb on - strand, within Rv1803cat 2046.047 kb on + strand, within Rv1803cat 2046.048 kb on - strand, within Rv1803cat 2046.226 kb on + strand, within Rv1803cat 2046.226 kb on + strand, within Rv1803cat 2046.226 kb on + strand, within Rv1803cat 2046.227 kb on - strand, within Rv1803cat 2046.227 kb on - strand, within Rv1803cat 2046.340 kb on - strand, within Rv1803cat 2046.340 kb on - strand, within Rv1803cat 2046.410 kb on - strand, within Rv1803cat 2046.410 kb on - strand, within Rv1803cat 2046.410 kb on - strand, within Rv1803cat 2046.411 kb on + strand, within Rv1803cat 2046.412 kb on - strand, within Rv1803cat 2046.577 kb on + strand, within Rv1803cat 2046.652 kb on + strandat 2046.653 kb on - strandat 2046.653 kb on - strandat 2046.776 kb on + strandat 2046.777 kb on - strandat 2046.777 kb on - strandat 2046.783 kb on + strandat 2046.875 kb on + strandat 2046.876 kb on - strandat 2046.914 kb on - strandat 2047.203 kb on + strand, within Rv1804cat 2047.204 kb on - strand, within Rv1804cat 2047.229 kb on + strand, within Rv1804cat 2047.229 kb on + strand, within Rv1804cat 2047.350 kb on - strandat 2047.414 kb on - strandat 2047.523 kb on - strandat 2047.607 kb on + strandat 2047.608 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.45 ug/mL
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2,044,023 + Rv1802 0.46 -0.3
2,044,024 - Rv1802 0.46 +0.4
2,044,024 - Rv1802 0.46 -0.6
2,044,024 - Rv1802 0.46 +0.4
2,044,071 + Rv1802 0.49 -0.1
2,044,072 - Rv1802 0.49 -0.3
2,044,087 - Rv1802 0.51 -0.6
2,044,087 - Rv1802 0.51 -0.4
2,044,087 - Rv1802 0.51 -0.3
2,044,088 + Rv1802 0.51 -0.2
2,044,089 - Rv1802 0.51 -0.2
2,044,150 + Rv1802 0.55 -0.1
2,044,151 - Rv1802 0.55 +0.2
2,044,153 + Rv1802 0.55 -0.9
2,044,154 - Rv1802 0.55 -0.1
2,044,154 - Rv1802 0.55 +0.3
2,044,240 + Rv1802 0.61 +0.1
2,044,442 + Rv1802 0.76 +0.5
2,044,442 + Rv1802 0.76 -0.1
2,044,443 - Rv1802 0.76 -0.4
2,044,679 - -0.6
2,045,253 + Rv1803c 0.17 -2.0
2,045,254 - Rv1803c 0.17 -1.3
2,045,254 - Rv1803c 0.17 -0.0
2,045,254 - Rv1803c 0.17 +0.0
2,045,310 - Rv1803c 0.20 +0.2
2,045,319 + Rv1803c 0.21 +1.2
2,045,320 - Rv1803c 0.21 +0.9
2,045,459 - Rv1803c 0.28 -0.5
2,045,460 + Rv1803c 0.28 +1.0
2,045,460 + Rv1803c 0.28 +0.0
2,045,460 + Rv1803c 0.28 +0.0
2,045,461 - Rv1803c 0.28 -0.2
2,045,461 - Rv1803c 0.28 +1.5
2,045,585 + Rv1803c 0.34 -0.2
2,045,585 + Rv1803c 0.34 -0.4
2,045,586 - Rv1803c 0.35 +0.3
2,045,601 - Rv1803c 0.35 -0.0
2,045,611 - Rv1803c 0.36 -0.6
2,045,777 + Rv1803c 0.44 -0.3
2,045,777 + Rv1803c 0.44 +0.2
2,045,778 - Rv1803c 0.45 -0.1
2,045,778 - Rv1803c 0.45 +2.2
2,045,778 - Rv1803c 0.45 +0.7
2,045,780 + Rv1803c 0.45 +0.5
2,046,010 - Rv1803c 0.57 +0.3
2,046,047 + Rv1803c 0.59 -0.4
2,046,048 - Rv1803c 0.59 -0.4
2,046,226 + Rv1803c 0.68 +0.0
2,046,226 + Rv1803c 0.68 -0.0
2,046,226 + Rv1803c 0.68 +0.4
2,046,227 - Rv1803c 0.68 +0.0
2,046,227 - Rv1803c 0.68 +3.3
2,046,340 - Rv1803c 0.74 +0.0
2,046,340 - Rv1803c 0.74 -0.4
2,046,410 - Rv1803c 0.77 -0.3
2,046,410 - Rv1803c 0.77 +0.7
2,046,410 - Rv1803c 0.77 -0.0
2,046,411 + Rv1803c 0.78 +0.5
2,046,412 - Rv1803c 0.78 +1.1
2,046,577 + Rv1803c 0.86 +0.0
2,046,652 + +0.5
2,046,653 - +0.2
2,046,653 - +0.4
2,046,776 + +0.4
2,046,777 - +0.3
2,046,777 - -0.2
2,046,783 + -0.1
2,046,875 + +0.7
2,046,876 - -0.4
2,046,914 - -0.4
2,047,203 + Rv1804c 0.55 -0.2
2,047,204 - Rv1804c 0.55 -0.3
2,047,229 + Rv1804c 0.63 +0.1
2,047,229 + Rv1804c 0.63 -0.2
2,047,350 - +0.3
2,047,414 - +0.2
2,047,523 - -0.3
2,047,607 + +0.1
2,047,608 - -0.0

Or see this region's nucleotide sequence