Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3165c

Experiment: 7H9 with Clofazimine 0.072 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3163c and Rv3164c are separated by 29 nucleotidesRv3164c and Rv3165c are separated by 7 nucleotidesRv3165c and Rv3166c overlap by 4 nucleotides Rv3163c: Rv3163c - Possible conserved secreted protein, at 3,531,642 to 3,532,913 Rv3163c Rv3164c: Rv3164c - Probable methanol dehydrogenase transcriptional regulatory protein MoxR3, at 3,532,943 to 3,533,905 Rv3164c Rv3165c: Rv3165c - Unknown protein, at 3,533,913 to 3,534,395 Rv3165c Rv3166c: Rv3166c - Conserved hypothetical protein, at 3,534,392 to 3,535,351 Rv3166c Position (kb) 3533 3534 3535Strain fitness (log2 ratio) -1 0 1 2at 3533.427 kb on + strand, within Rv3164cat 3533.427 kb on + strand, within Rv3164cat 3533.428 kb on - strand, within Rv3164cat 3533.439 kb on + strand, within Rv3164cat 3533.900 kb on - strandat 3533.916 kb on + strandat 3534.080 kb on + strand, within Rv3165cat 3534.395 kb on + strandat 3534.526 kb on + strand, within Rv3166cat 3534.639 kb on + strand, within Rv3166cat 3534.639 kb on + strand, within Rv3166cat 3534.805 kb on + strand, within Rv3166cat 3535.340 kb on - strandat 3535.342 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.072 ug/mL
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3,533,427 + Rv3164c 0.50 +0.0
3,533,427 + Rv3164c 0.50 +0.3
3,533,428 - Rv3164c 0.50 +2.4
3,533,439 + Rv3164c 0.52 -0.2
3,533,900 - -0.8
3,533,916 + +0.2
3,534,080 + Rv3165c 0.35 +0.1
3,534,395 + -0.3
3,534,526 + Rv3166c 0.14 -0.3
3,534,639 + Rv3166c 0.26 -0.6
3,534,639 + Rv3166c 0.26 -0.3
3,534,805 + Rv3166c 0.43 -0.2
3,535,340 - +0.4
3,535,342 + -0.4

Or see this region's nucleotide sequence