Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2136c

Experiment: 7H9 with Clofazimine 0.072 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2134c and Rv2135c are separated by 63 nucleotidesRv2135c and Rv2136c overlap by 4 nucleotidesRv2136c and Rv2137c are separated by 63 nucleotidesRv2137c and Rv2138 are separated by 14 nucleotides Rv2134c: Rv2134c - Conserved protein, at 2,394,650 to 2,395,237 Rv2134c Rv2135c: Rv2135c - Conserved protein, at 2,395,301 to 2,396,011 Rv2135c Rv2136c: Rv2136c - Possible conserved transmembrane protein, at 2,396,008 to 2,396,838 Rv2136c Rv2137c: Rv2137c - Conserved hypothetical protein, at 2,396,902 to 2,397,315 Rv2137c Rv2138: Rv2138 - Probable conserved lipoprotein LppL, at 2,397,330 to 2,398,406 Rv2138 Position (kb) 2396 2397Strain fitness (log2 ratio) -2 -1 0 1 2at 2395.151 kb on + strand, within Rv2134cat 2395.151 kb on + strand, within Rv2134cat 2395.151 kb on + strand, within Rv2134cat 2395.152 kb on - strand, within Rv2134cat 2395.155 kb on + strand, within Rv2134cat 2395.156 kb on - strand, within Rv2134cat 2395.156 kb on - strand, within Rv2134cat 2395.217 kb on + strandat 2395.218 kb on - strandat 2395.218 kb on - strandat 2395.218 kb on - strandat 2395.302 kb on + strandat 2395.994 kb on + strandat 2396.087 kb on + strandat 2396.087 kb on + strandat 2396.088 kb on - strandat 2396.574 kb on - strand, within Rv2136cat 2396.574 kb on - strand, within Rv2136cat 2396.653 kb on - strand, within Rv2136cat 2396.666 kb on + strand, within Rv2136cat 2396.667 kb on - strand, within Rv2136cat 2396.675 kb on - strand, within Rv2136cat 2396.675 kb on - strand, within Rv2136cat 2396.903 kb on + strandat 2397.148 kb on + strand, within Rv2137cat 2397.150 kb on + strand, within Rv2137cat 2397.221 kb on + strand, within Rv2137cat 2397.221 kb on + strand, within Rv2137cat 2397.221 kb on + strand, within Rv2137cat 2397.222 kb on - strand, within Rv2137cat 2397.334 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.072 ug/mL
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2,395,151 + Rv2134c 0.85 +0.1
2,395,151 + Rv2134c 0.85 -1.7
2,395,151 + Rv2134c 0.85 +1.0
2,395,152 - Rv2134c 0.85 +1.8
2,395,155 + Rv2134c 0.86 +0.4
2,395,156 - Rv2134c 0.86 +1.2
2,395,156 - Rv2134c 0.86 -0.2
2,395,217 + -0.2
2,395,218 - -1.6
2,395,218 - -0.4
2,395,218 - +0.2
2,395,302 + +0.3
2,395,994 + +0.4
2,396,087 + -0.1
2,396,087 + +0.1
2,396,088 - -1.2
2,396,574 - Rv2136c 0.68 -1.2
2,396,574 - Rv2136c 0.68 -1.1
2,396,653 - Rv2136c 0.78 -1.9
2,396,666 + Rv2136c 0.79 +1.2
2,396,667 - Rv2136c 0.79 -0.6
2,396,675 - Rv2136c 0.80 -0.1
2,396,675 - Rv2136c 0.80 -1.1
2,396,903 + -0.5
2,397,148 + Rv2137c 0.59 -0.7
2,397,150 + Rv2137c 0.60 -1.7
2,397,221 + Rv2137c 0.77 +0.0
2,397,221 + Rv2137c 0.77 +1.4
2,397,221 + Rv2137c 0.77 +0.2
2,397,222 - Rv2137c 0.77 -0.6
2,397,334 + -0.0

Or see this region's nucleotide sequence