Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2869c

Experiment: 7H9 with Clofazimine 0.072 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2868c and Rv2869c are separated by 16 nucleotidesRv2869c and Rv2870c are separated by 7 nucleotides Rv2868c: Rv2868c - Probable GcpE protein, at 3,179,368 to 3,180,531 Rv2868c Rv2869c: Rv2869c - Membrane bound metalloprotease, at 3,180,548 to 3,181,762 Rv2869c Rv2870c: Rv2870c - Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase), at 3,181,770 to 3,183,011 Rv2870c Position (kb) 3180 3181 3182Strain fitness (log2 ratio) -4 -3 -2 -1 0 1at 3180.604 kb on - strandat 3180.631 kb on - strandat 3180.631 kb on - strandat 3180.734 kb on - strand, within Rv2869cat 3180.876 kb on - strand, within Rv2869cat 3181.138 kb on - strand, within Rv2869cat 3181.783 kb on - strandat 3181.855 kb on - strandat 3181.855 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.072 ug/mL
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3,180,604 - -1.3
3,180,631 - -2.3
3,180,631 - -4.3
3,180,734 - Rv2869c 0.15 -3.0
3,180,876 - Rv2869c 0.27 -1.9
3,181,138 - Rv2869c 0.49 -0.9
3,181,783 - -0.7
3,181,855 - -0.3
3,181,855 - -0.2

Or see this region's nucleotide sequence