Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1969

Experiment: 7H9 with Clofazimine 0.072 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1968 and Rv1969 overlap by 4 nucleotidesRv1969 and Rv1970 overlap by 4 nucleotides Rv1968: Rv1968 - Mce-family protein Mce3C, at 2,211,626 to 2,212,858 Rv1968 Rv1969: Rv1969 - Mce-family protein Mce3D, at 2,212,855 to 2,214,126 Rv1969 Rv1970: Rv1970 - Possible Mce-family lipoprotein LprM (Mce-family lipoprotein Mce3E), at 2,214,123 to 2,215,256 Rv1970 Position (kb) 2212 2213 2214 2215Strain fitness (log2 ratio) -2 -1 0 1 2at 2212.019 kb on + strand, within Rv1968at 2212.124 kb on - strand, within Rv1968at 2212.544 kb on + strand, within Rv1968at 2212.544 kb on + strand, within Rv1968at 2212.544 kb on + strand, within Rv1968at 2212.545 kb on - strand, within Rv1968at 2212.545 kb on - strand, within Rv1968at 2213.102 kb on - strand, within Rv1969at 2213.102 kb on - strand, within Rv1969at 2213.216 kb on + strand, within Rv1969at 2213.217 kb on - strand, within Rv1969at 2213.979 kb on + strand, within Rv1969at 2214.163 kb on + strandat 2215.048 kb on - strand, within Rv1970

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Clofazimine 0.072 ug/mL
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2,212,019 + Rv1968 0.32 +0.0
2,212,124 - Rv1968 0.40 +0.2
2,212,544 + Rv1968 0.74 -0.1
2,212,544 + Rv1968 0.74 -0.2
2,212,544 + Rv1968 0.74 -0.7
2,212,545 - Rv1968 0.75 +0.1
2,212,545 - Rv1968 0.75 +0.6
2,213,102 - Rv1969 0.19 -0.7
2,213,102 - Rv1969 0.19 -2.1
2,213,216 + Rv1969 0.28 -0.1
2,213,217 - Rv1969 0.28 +2.0
2,213,979 + Rv1969 0.88 -0.2
2,214,163 + -1.0
2,215,048 - Rv1970 0.82 +0.2

Or see this region's nucleotide sequence