Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2776c

Experiment: 7H9 with Linezolid 0.44 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2774c and Rv2775 are separated by 152 nucleotidesRv2775 and Rv2776c are separated by 3 nucleotidesRv2776c and Rv2777c are separated by 181 nucleotides Rv2774c: Rv2774c - Hypothetical protein, at 3,082,352 to 3,082,756 Rv2774c Rv2775: Rv2775 - GCN5-related N-acetyltransferase, at 3,082,909 to 3,083,370 Rv2775 Rv2776c: Rv2776c - Probable oxidoreductase, at 3,083,374 to 3,084,303 Rv2776c Rv2777c: Rv2777c - Conserved hypothetical protein, at 3,084,485 to 3,085,555 Rv2777c Position (kb) 3083 3084 3085Strain fitness (log2 ratio) -2 -1 0 1 2at 3082.454 kb on - strand, within Rv2774cat 3082.454 kb on - strand, within Rv2774cat 3082.800 kb on + strandat 3082.801 kb on - strandat 3082.804 kb on + strandat 3082.805 kb on - strandat 3082.805 kb on - strandat 3082.861 kb on - strandat 3082.961 kb on + strand, within Rv2775at 3083.037 kb on + strand, within Rv2775at 3083.038 kb on - strand, within Rv2775at 3083.131 kb on + strand, within Rv2775at 3083.131 kb on + strand, within Rv2775at 3083.132 kb on - strand, within Rv2775at 3083.132 kb on - strand, within Rv2775at 3083.257 kb on + strand, within Rv2775at 3083.347 kb on + strandat 3083.660 kb on + strand, within Rv2776cat 3083.710 kb on + strand, within Rv2776cat 3083.711 kb on - strand, within Rv2776cat 3083.735 kb on + strand, within Rv2776cat 3083.736 kb on - strand, within Rv2776cat 3083.842 kb on + strand, within Rv2776cat 3084.117 kb on + strand, within Rv2776cat 3084.146 kb on + strand, within Rv2776cat 3084.146 kb on + strand, within Rv2776cat 3084.276 kb on + strandat 3084.364 kb on + strandat 3084.365 kb on - strandat 3084.365 kb on - strandat 3084.365 kb on - strandat 3084.427 kb on - strandat 3084.469 kb on + strandat 3084.470 kb on - strandat 3084.522 kb on + strandat 3084.523 kb on - strandat 3084.576 kb on + strandat 3084.576 kb on + strandat 3084.576 kb on + strandat 3084.580 kb on - strandat 3084.682 kb on - strand, within Rv2777cat 3084.696 kb on + strand, within Rv2777cat 3084.697 kb on - strand, within Rv2777cat 3084.930 kb on + strand, within Rv2777cat 3084.930 kb on + strand, within Rv2777cat 3084.965 kb on + strand, within Rv2777cat 3084.966 kb on - strand, within Rv2777cat 3084.978 kb on + strand, within Rv2777cat 3084.979 kb on - strand, within Rv2777cat 3084.979 kb on - strand, within Rv2777cat 3084.979 kb on - strand, within Rv2777cat 3085.048 kb on + strand, within Rv2777cat 3085.232 kb on - strand, within Rv2777cat 3085.232 kb on - strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.278 kb on + strand, within Rv2777cat 3085.279 kb on - strand, within Rv2777cat 3085.279 kb on - strand, within Rv2777cat 3085.279 kb on - strand, within Rv2777c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Linezolid 0.44 ug/mL
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3,082,454 - Rv2774c 0.25 +1.8
3,082,454 - Rv2774c 0.25 +1.5
3,082,800 + +0.8
3,082,801 - -0.7
3,082,804 + -0.5
3,082,805 - +1.0
3,082,805 - -0.5
3,082,861 - -0.5
3,082,961 + Rv2775 0.11 -0.5
3,083,037 + Rv2775 0.28 +0.0
3,083,038 - Rv2775 0.28 +0.3
3,083,131 + Rv2775 0.48 -1.1
3,083,131 + Rv2775 0.48 -0.2
3,083,132 - Rv2775 0.48 +0.2
3,083,132 - Rv2775 0.48 -0.4
3,083,257 + Rv2775 0.75 +0.3
3,083,347 + -0.7
3,083,660 + Rv2776c 0.31 -0.3
3,083,710 + Rv2776c 0.36 -0.3
3,083,711 - Rv2776c 0.36 -2.2
3,083,735 + Rv2776c 0.39 +0.2
3,083,736 - Rv2776c 0.39 -0.8
3,083,842 + Rv2776c 0.50 -1.2
3,084,117 + Rv2776c 0.80 -0.5
3,084,146 + Rv2776c 0.83 -1.9
3,084,146 + Rv2776c 0.83 +0.1
3,084,276 + -0.1
3,084,364 + -0.3
3,084,365 - -0.8
3,084,365 - +0.2
3,084,365 - +0.2
3,084,427 - +0.5
3,084,469 + -0.9
3,084,470 - -1.0
3,084,522 + +0.0
3,084,523 - -0.6
3,084,576 + +0.8
3,084,576 + +0.1
3,084,576 + -0.7
3,084,580 - -0.2
3,084,682 - Rv2777c 0.18 -0.3
3,084,696 + Rv2777c 0.20 +0.1
3,084,697 - Rv2777c 0.20 +1.8
3,084,930 + Rv2777c 0.42 -0.9
3,084,930 + Rv2777c 0.42 +0.0
3,084,965 + Rv2777c 0.45 -0.1
3,084,966 - Rv2777c 0.45 +0.4
3,084,978 + Rv2777c 0.46 +1.0
3,084,979 - Rv2777c 0.46 -0.6
3,084,979 - Rv2777c 0.46 -0.5
3,084,979 - Rv2777c 0.46 -0.5
3,085,048 + Rv2777c 0.53 -0.1
3,085,232 - Rv2777c 0.70 -0.2
3,085,232 - Rv2777c 0.70 +0.2
3,085,278 + Rv2777c 0.74 +0.1
3,085,278 + Rv2777c 0.74 -0.4
3,085,278 + Rv2777c 0.74 -0.5
3,085,278 + Rv2777c 0.74 -0.2
3,085,279 - Rv2777c 0.74 +0.8
3,085,279 - Rv2777c 0.74 +1.8
3,085,279 - Rv2777c 0.74 +0.2

Or see this region's nucleotide sequence