Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1504c

Experiment: 7H9 with Linezolid 0.44 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1502 and Rv1503c are separated by 172 nucleotidesRv1503c and Rv1504c are separated by 0 nucleotidesRv1504c and Rv1505c are separated by 136 nucleotidesRv1505c and Rv1506c overlap by 4 nucleotides Rv1502: Rv1502 - Hypothetical protein, at 1,692,924 to 1,693,823 Rv1502 Rv1503c: Rv1503c - Conserved hypothetical protein, at 1,693,996 to 1,694,544 Rv1503c Rv1504c: Rv1504c - Conserved hypothetical protein, at 1,694,545 to 1,695,144 Rv1504c Rv1505c: Rv1505c - Conserved hypothetical protein, at 1,695,281 to 1,695,946 Rv1505c Rv1506c: Rv1506c - Hypothetical protein, at 1,695,943 to 1,696,443 Rv1506c Position (kb) 1694 1695 1696Strain fitness (log2 ratio) -2 -1 0 1 2at 1693.840 kb on - strandat 1693.992 kb on - strandat 1694.050 kb on + strandat 1694.051 kb on - strand, within Rv1503cat 1694.194 kb on - strand, within Rv1503cat 1694.245 kb on + strand, within Rv1503cat 1694.246 kb on - strand, within Rv1503cat 1694.246 kb on - strand, within Rv1503cat 1694.248 kb on + strand, within Rv1503cat 1694.248 kb on + strand, within Rv1503cat 1694.255 kb on + strand, within Rv1503cat 1694.258 kb on + strand, within Rv1503cat 1694.259 kb on - strand, within Rv1503cat 1694.259 kb on - strand, within Rv1503cat 1694.259 kb on - strand, within Rv1503cat 1694.259 kb on - strand, within Rv1503cat 1694.259 kb on - strand, within Rv1503cat 1694.546 kb on + strandat 1694.546 kb on + strandat 1694.651 kb on + strand, within Rv1504cat 1694.751 kb on - strand, within Rv1504cat 1694.751 kb on - strand, within Rv1504cat 1694.795 kb on - strand, within Rv1504cat 1694.897 kb on + strand, within Rv1504cat 1694.897 kb on + strand, within Rv1504cat 1694.898 kb on - strand, within Rv1504cat 1694.908 kb on + strand, within Rv1504cat 1694.909 kb on - strand, within Rv1504cat 1694.930 kb on - strand, within Rv1504cat 1694.930 kb on - strand, within Rv1504cat 1694.983 kb on + strand, within Rv1504cat 1694.983 kb on + strand, within Rv1504cat 1694.983 kb on + strand, within Rv1504cat 1694.983 kb on + strand, within Rv1504cat 1694.983 kb on + strand, within Rv1504cat 1694.984 kb on - strand, within Rv1504cat 1694.984 kb on - strand, within Rv1504cat 1695.087 kb on - strandat 1695.111 kb on - strandat 1695.275 kb on - strandat 1695.335 kb on + strandat 1695.336 kb on - strandat 1695.337 kb on + strandat 1695.340 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Linezolid 0.44 ug/mL
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1,693,840 - +1.8
1,693,992 - -0.7
1,694,050 + -0.8
1,694,051 - Rv1503c 0.10 -1.0
1,694,194 - Rv1503c 0.36 -0.0
1,694,245 + Rv1503c 0.45 -0.0
1,694,246 - Rv1503c 0.46 -1.1
1,694,246 - Rv1503c 0.46 -0.2
1,694,248 + Rv1503c 0.46 -1.6
1,694,248 + Rv1503c 0.46 -0.2
1,694,255 + Rv1503c 0.47 -0.0
1,694,258 + Rv1503c 0.48 +0.5
1,694,259 - Rv1503c 0.48 -0.2
1,694,259 - Rv1503c 0.48 -0.5
1,694,259 - Rv1503c 0.48 -0.3
1,694,259 - Rv1503c 0.48 +0.4
1,694,259 - Rv1503c 0.48 -0.0
1,694,546 + -0.6
1,694,546 + +1.8
1,694,651 + Rv1504c 0.18 +1.2
1,694,751 - Rv1504c 0.34 -2.0
1,694,751 - Rv1504c 0.34 -0.1
1,694,795 - Rv1504c 0.42 +0.1
1,694,897 + Rv1504c 0.59 -0.2
1,694,897 + Rv1504c 0.59 +0.0
1,694,898 - Rv1504c 0.59 -0.2
1,694,908 + Rv1504c 0.60 +0.8
1,694,909 - Rv1504c 0.61 +1.5
1,694,930 - Rv1504c 0.64 +0.5
1,694,930 - Rv1504c 0.64 +1.0
1,694,983 + Rv1504c 0.73 -0.5
1,694,983 + Rv1504c 0.73 +0.0
1,694,983 + Rv1504c 0.73 +0.2
1,694,983 + Rv1504c 0.73 -0.4
1,694,983 + Rv1504c 0.73 +0.1
1,694,984 - Rv1504c 0.73 -0.2
1,694,984 - Rv1504c 0.73 +0.2
1,695,087 - -0.8
1,695,111 - -0.0
1,695,275 - +1.1
1,695,335 + -0.3
1,695,336 - -0.2
1,695,337 + -0.8
1,695,340 - -0.2

Or see this region's nucleotide sequence