Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0263c

Experiment: 7H9 with Linezolid 0.44 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0261c and Rv0262c are separated by 140 nucleotidesRv0262c and Rv0263c are separated by 9 nucleotidesRv0263c and Rv0264c are separated by 16 nucleotidesRv0264c and Rv0265c are separated by 95 nucleotides Rv0261c: Rv0261c - Probable integral membrane nitrite extrusion protein NarK3 (nitrite facilitator), at 312,759 to 314,168 Rv0261c Rv0262c: Rv0262c - Aminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC), at 314,309 to 314,854 Rv0262c Rv0263c: Rv0263c - Conserved hypothetical protein, at 314,864 to 315,766 Rv0263c Rv0264c: Rv0264c - Conserved hypothetical protein, at 315,783 to 316,415 Rv0264c Rv0265c: Rv0265c - Probable periplasmic iron-transport lipoprotein, at 316,511 to 317,503 Rv0265c Position (kb) 314 315 316Strain fitness (log2 ratio) -2 -1 0 1at 313.918 kb on + strand, within Rv0261cat 314.169 kb on - strandat 314.179 kb on - strandat 314.310 kb on + strandat 314.478 kb on + strand, within Rv0262cat 314.523 kb on + strand, within Rv0262cat 314.617 kb on - strand, within Rv0262cat 314.617 kb on - strand, within Rv0262cat 314.643 kb on + strand, within Rv0262cat 314.880 kb on - strandat 314.997 kb on + strand, within Rv0263cat 315.117 kb on - strand, within Rv0263cat 315.178 kb on + strand, within Rv0263cat 315.178 kb on + strand, within Rv0263cat 315.424 kb on - strand, within Rv0263cat 315.908 kb on - strand, within Rv0264cat 315.908 kb on - strand, within Rv0264cat 315.908 kb on - strand, within Rv0264cat 315.909 kb on + strand, within Rv0264cat 316.502 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Linezolid 0.44 ug/mL
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313,918 + Rv0261c 0.82 -0.3
314,169 - -1.0
314,179 - +0.4
314,310 + -0.5
314,478 + Rv0262c 0.31 -0.5
314,523 + Rv0262c 0.39 -0.8
314,617 - Rv0262c 0.56 +0.2
314,617 - Rv0262c 0.56 -0.3
314,643 + Rv0262c 0.61 -0.8
314,880 - -1.3
314,997 + Rv0263c 0.15 -1.9
315,117 - Rv0263c 0.28 -0.2
315,178 + Rv0263c 0.35 -0.4
315,178 + Rv0263c 0.35 -1.0
315,424 - Rv0263c 0.62 -0.5
315,908 - Rv0264c 0.20 -0.2
315,908 - Rv0264c 0.20 -0.4
315,908 - Rv0264c 0.20 +0.7
315,909 + Rv0264c 0.20 -0.9
316,502 - -0.6

Or see this region's nucleotide sequence