Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0534c

Experiment: 7H9 with Ethambutol 0.75 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0533c and Rv0534c are separated by 81 nucleotidesRv0534c and Rv0535 are separated by 16 nucleotidesRv0535 and Rv0536 overlap by 4 nucleotides Rv0532: Rv0532 - PE-PGRS family protein PE_PGRS6, at 622,793 to 624,577 Rv0532 Rv0533c: Rv0533c - 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III), at 624,473 to 625,480 Rv0533c Rv0534c: Rv0534c - 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase), at 625,562 to 626,440 Rv0534c Rv0535: Rv0535 - Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase), at 626,457 to 627,251 Rv0535 Rv0536: Rv0536 - Probable UDP-glucose 4-epimerase GalE3 (galactowaldenase) (UDP-galactose 4-epimerase) (uridine diphosphate galactose 4-epimerase) (uridine diphospho-galactose 4-epimerase), at 627,248 to 628,288 Rv0536 Position (kb) 625 626 627Strain fitness (log2 ratio) -1 0 1 2 3at 624.575 kb on + strandat 624.632 kb on - strand, within Rv0533cat 624.697 kb on + strand, within Rv0533cat 624.726 kb on - strand, within Rv0533cat 624.726 kb on - strand, within Rv0533cat 624.885 kb on - strand, within Rv0533cat 625.005 kb on + strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.006 kb on - strand, within Rv0533cat 625.013 kb on + strand, within Rv0533cat 625.013 kb on + strand, within Rv0533cat 625.014 kb on - strand, within Rv0533cat 625.014 kb on - strand, within Rv0533cat 625.102 kb on - strand, within Rv0533cat 625.142 kb on + strand, within Rv0533cat 625.350 kb on + strand, within Rv0533cat 625.385 kb on + strandat 625.385 kb on + strandat 625.386 kb on - strandat 625.419 kb on + strandat 625.481 kb on - strandat 625.489 kb on + strandat 625.489 kb on + strandat 625.490 kb on - strandat 625.490 kb on - strandat 625.490 kb on - strandat 625.563 kb on + strandat 625.564 kb on - strandat 626.456 kb on + strandat 626.457 kb on - strandat 626.505 kb on + strandat 626.506 kb on - strandat 626.506 kb on - strandat 626.811 kb on + strand, within Rv0535at 626.812 kb on - strand, within Rv0535at 626.812 kb on - strand, within Rv0535at 626.812 kb on - strand, within Rv0535

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethambutol 0.75 ug/mL
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624,575 + -0.3
624,632 - Rv0533c 0.16 -0.2
624,697 + Rv0533c 0.22 -0.5
624,726 - Rv0533c 0.25 +0.3
624,726 - Rv0533c 0.25 +0.3
624,885 - Rv0533c 0.41 -0.2
625,005 + Rv0533c 0.53 +2.9
625,006 - Rv0533c 0.53 -0.3
625,006 - Rv0533c 0.53 -1.3
625,006 - Rv0533c 0.53 -0.2
625,006 - Rv0533c 0.53 -0.2
625,013 + Rv0533c 0.54 -0.0
625,013 + Rv0533c 0.54 -0.4
625,014 - Rv0533c 0.54 +0.5
625,014 - Rv0533c 0.54 -0.1
625,102 - Rv0533c 0.62 -0.0
625,142 + Rv0533c 0.66 -0.7
625,350 + Rv0533c 0.87 +0.0
625,385 + -0.1
625,385 + -0.3
625,386 - -0.1
625,419 + +0.0
625,481 - -0.1
625,489 + -0.8
625,489 + -0.3
625,490 - -0.6
625,490 - +0.9
625,490 - -0.5
625,563 + +0.7
625,564 - +0.2
626,456 + +0.3
626,457 - -0.6
626,505 + -0.2
626,506 - -0.2
626,506 - +0.8
626,811 + Rv0535 0.45 -0.7
626,812 - Rv0535 0.45 -1.3
626,812 - Rv0535 0.45 +0.8
626,812 - Rv0535 0.45 +0.4

Or see this region's nucleotide sequence