Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3404c

Experiment: 7H9 with Ethambutol 0.75 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3403c and Rv3404c are separated by 16 nucleotidesRv3404c and Rv3405c are separated by 117 nucleotidesRv3405c and Rv3406 are separated by 61 nucleotides Rv3403c: Rv3403c - Hypothetical protein, at 3,822,262 to 3,823,863 Rv3403c Rv3404c: Rv3404c - Conserved hypothetical protein, at 3,823,880 to 3,824,584 Rv3404c Rv3405c: Rv3405c - Possible transcriptional regulatory protein, at 3,824,702 to 3,825,268 Rv3405c Rv3406: Rv3406 - Probable dioxygenase, at 3,825,330 to 3,826,217 Rv3406 Position (kb) 3823 3824 3825Strain fitness (log2 ratio) -2 -1 0 1 2 3at 3822.927 kb on + strand, within Rv3403cat 3822.987 kb on - strand, within Rv3403cat 3822.987 kb on - strand, within Rv3403cat 3822.987 kb on - strand, within Rv3403cat 3823.060 kb on + strand, within Rv3403cat 3823.061 kb on - strand, within Rv3403cat 3823.061 kb on - strand, within Rv3403cat 3823.064 kb on + strand, within Rv3403cat 3823.065 kb on - strand, within Rv3403cat 3823.106 kb on - strand, within Rv3403cat 3823.106 kb on - strand, within Rv3403cat 3823.185 kb on - strand, within Rv3403cat 3823.197 kb on + strand, within Rv3403cat 3823.198 kb on - strand, within Rv3403cat 3823.199 kb on + strand, within Rv3403cat 3823.199 kb on + strand, within Rv3403cat 3823.199 kb on + strand, within Rv3403cat 3823.199 kb on + strand, within Rv3403cat 3823.199 kb on + strand, within Rv3403cat 3823.199 kb on + strand, within Rv3403cat 3823.200 kb on - strand, within Rv3403cat 3823.200 kb on - strand, within Rv3403cat 3823.200 kb on - strand, within Rv3403cat 3823.326 kb on - strand, within Rv3403cat 3823.439 kb on - strand, within Rv3403cat 3823.439 kb on - strand, within Rv3403cat 3823.463 kb on + strand, within Rv3403cat 3823.464 kb on - strand, within Rv3403cat 3823.779 kb on + strandat 3823.779 kb on + strandat 3823.779 kb on + strandat 3823.779 kb on + strandat 3823.780 kb on - strandat 3823.821 kb on + strandat 3823.821 kb on + strandat 3823.821 kb on + strandat 3823.821 kb on + strandat 3823.821 kb on + strandat 3823.822 kb on - strandat 3823.822 kb on - strandat 3823.822 kb on - strandat 3823.836 kb on + strandat 3823.836 kb on + strandat 3823.837 kb on - strandat 3823.837 kb on - strandat 3823.837 kb on - strandat 3823.859 kb on - strandat 3824.095 kb on + strand, within Rv3404cat 3824.103 kb on + strand, within Rv3404cat 3824.103 kb on + strand, within Rv3404cat 3824.103 kb on + strand, within Rv3404cat 3824.103 kb on + strand, within Rv3404cat 3824.103 kb on + strand, within Rv3404cat 3824.104 kb on - strand, within Rv3404cat 3824.104 kb on - strand, within Rv3404cat 3824.104 kb on - strand, within Rv3404cat 3824.104 kb on - strand, within Rv3404cat 3824.104 kb on - strand, within Rv3404cat 3824.172 kb on + strand, within Rv3404cat 3824.326 kb on - strand, within Rv3404cat 3824.326 kb on - strand, within Rv3404cat 3824.395 kb on + strand, within Rv3404cat 3824.396 kb on - strand, within Rv3404cat 3824.396 kb on - strand, within Rv3404cat 3824.421 kb on + strand, within Rv3404cat 3824.499 kb on + strand, within Rv3404cat 3824.499 kb on + strand, within Rv3404cat 3824.499 kb on + strand, within Rv3404cat 3824.510 kb on - strand, within Rv3404cat 3824.576 kb on + strandat 3824.577 kb on - strandat 3824.645 kb on + strandat 3824.664 kb on - strandat 3824.750 kb on + strandat 3824.750 kb on + strandat 3824.750 kb on + strandat 3824.750 kb on + strandat 3824.751 kb on - strandat 3824.751 kb on - strandat 3824.751 kb on - strandat 3824.874 kb on + strand, within Rv3405cat 3825.213 kb on - strandat 3825.213 kb on - strandat 3825.344 kb on + strandat 3825.345 kb on - strandat 3825.446 kb on - strand, within Rv3406

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethambutol 0.75 ug/mL
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3,822,927 + Rv3403c 0.42 -0.3
3,822,987 - Rv3403c 0.45 -0.6
3,822,987 - Rv3403c 0.45 -0.5
3,822,987 - Rv3403c 0.45 -0.5
3,823,060 + Rv3403c 0.50 -0.2
3,823,061 - Rv3403c 0.50 -0.2
3,823,061 - Rv3403c 0.50 +0.9
3,823,064 + Rv3403c 0.50 -0.1
3,823,065 - Rv3403c 0.50 -0.7
3,823,106 - Rv3403c 0.53 -2.2
3,823,106 - Rv3403c 0.53 +0.0
3,823,185 - Rv3403c 0.58 -0.4
3,823,197 + Rv3403c 0.58 -1.9
3,823,198 - Rv3403c 0.58 -0.4
3,823,199 + Rv3403c 0.58 -1.9
3,823,199 + Rv3403c 0.58 +0.1
3,823,199 + Rv3403c 0.58 +0.3
3,823,199 + Rv3403c 0.58 -1.4
3,823,199 + Rv3403c 0.58 -0.6
3,823,199 + Rv3403c 0.58 -0.6
3,823,200 - Rv3403c 0.59 -0.2
3,823,200 - Rv3403c 0.59 -1.5
3,823,200 - Rv3403c 0.59 +1.1
3,823,326 - Rv3403c 0.66 -0.0
3,823,439 - Rv3403c 0.73 +0.3
3,823,439 - Rv3403c 0.73 -0.5
3,823,463 + Rv3403c 0.75 -0.7
3,823,464 - Rv3403c 0.75 -0.9
3,823,779 + -0.1
3,823,779 + -0.1
3,823,779 + +2.9
3,823,779 + +0.2
3,823,780 - -0.2
3,823,821 + -0.6
3,823,821 + -1.6
3,823,821 + +0.1
3,823,821 + -0.2
3,823,821 + +0.7
3,823,822 - -0.8
3,823,822 - -0.2
3,823,822 - -0.4
3,823,836 + +0.3
3,823,836 + -0.3
3,823,837 - -0.5
3,823,837 - -0.4
3,823,837 - -0.5
3,823,859 - -0.9
3,824,095 + Rv3404c 0.30 -1.5
3,824,103 + Rv3404c 0.32 -0.6
3,824,103 + Rv3404c 0.32 -0.2
3,824,103 + Rv3404c 0.32 -0.4
3,824,103 + Rv3404c 0.32 -0.1
3,824,103 + Rv3404c 0.32 -0.1
3,824,104 - Rv3404c 0.32 -0.5
3,824,104 - Rv3404c 0.32 -0.6
3,824,104 - Rv3404c 0.32 +0.0
3,824,104 - Rv3404c 0.32 -1.1
3,824,104 - Rv3404c 0.32 -1.0
3,824,172 + Rv3404c 0.41 -1.1
3,824,326 - Rv3404c 0.63 -0.5
3,824,326 - Rv3404c 0.63 +0.3
3,824,395 + Rv3404c 0.73 -0.1
3,824,396 - Rv3404c 0.73 -0.1
3,824,396 - Rv3404c 0.73 -0.1
3,824,421 + Rv3404c 0.77 -0.2
3,824,499 + Rv3404c 0.88 -1.1
3,824,499 + Rv3404c 0.88 -0.1
3,824,499 + Rv3404c 0.88 -0.2
3,824,510 - Rv3404c 0.89 +0.3
3,824,576 + -0.2
3,824,577 - +0.1
3,824,645 + -1.2
3,824,664 - -0.2
3,824,750 + +0.5
3,824,750 + -0.4
3,824,750 + -0.4
3,824,750 + -0.6
3,824,751 - +0.0
3,824,751 - +0.9
3,824,751 - +0.1
3,824,874 + Rv3405c 0.30 -0.8
3,825,213 - -0.1
3,825,213 - -1.5
3,825,344 + +1.1
3,825,345 - -1.7
3,825,446 - Rv3406 0.13 +0.4

Or see this region's nucleotide sequence