Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3238c

Experiment: 7H9 with Ethambutol 0.75 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3236c and Rv3237c are separated by 4 nucleotidesRv3237c and Rv3238c are separated by 60 nucleotidesRv3238c and Rv3239c are separated by 58 nucleotides Rv3236c: Rv3236c - Probable conserved integral membrane transport protein, at 3,611,959 to 3,613,116 Rv3236c Rv3237c: Rv3237c - Conserved protein, at 3,613,121 to 3,613,603 Rv3237c Rv3238c: Rv3238c - Probable conserved integral membrane protein, at 3,613,664 to 3,614,398 Rv3238c Rv3239c: Rv3239c - Probable conserved transmembrane transport protein, at 3,614,457 to 3,617,603 Rv3239c Position (kb) 3613 3614 3615Strain fitness (log2 ratio) -1 0 1 2at 3612.741 kb on - strand, within Rv3236cat 3613.288 kb on + strand, within Rv3237cat 3613.289 kb on - strand, within Rv3237cat 3613.319 kb on - strand, within Rv3237cat 3613.319 kb on - strand, within Rv3237cat 3613.486 kb on - strand, within Rv3237cat 3613.546 kb on - strand, within Rv3237cat 3613.561 kb on - strandat 3613.603 kb on + strandat 3613.603 kb on + strandat 3613.603 kb on + strandat 3613.603 kb on + strandat 3613.636 kb on + strandat 3613.636 kb on + strandat 3613.669 kb on + strandat 3613.669 kb on + strandat 3613.670 kb on - strandat 3613.745 kb on + strand, within Rv3238cat 3613.745 kb on + strand, within Rv3238cat 3613.783 kb on - strand, within Rv3238cat 3613.921 kb on - strand, within Rv3238cat 3613.944 kb on + strand, within Rv3238cat 3613.944 kb on + strand, within Rv3238cat 3613.945 kb on - strand, within Rv3238cat 3613.945 kb on - strand, within Rv3238cat 3613.955 kb on + strand, within Rv3238cat 3613.956 kb on - strand, within Rv3238cat 3614.101 kb on - strand, within Rv3238cat 3614.101 kb on - strand, within Rv3238cat 3614.132 kb on + strand, within Rv3238cat 3614.132 kb on + strand, within Rv3238cat 3614.132 kb on + strand, within Rv3238cat 3614.133 kb on - strand, within Rv3238cat 3614.133 kb on - strand, within Rv3238cat 3614.133 kb on - strand, within Rv3238cat 3614.133 kb on - strand, within Rv3238cat 3614.136 kb on + strand, within Rv3238cat 3614.136 kb on + strand, within Rv3238cat 3614.136 kb on + strand, within Rv3238cat 3614.136 kb on + strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.137 kb on - strand, within Rv3238cat 3614.209 kb on + strand, within Rv3238cat 3614.209 kb on + strand, within Rv3238cat 3614.210 kb on - strand, within Rv3238cat 3614.288 kb on + strand, within Rv3238cat 3614.306 kb on + strand, within Rv3238cat 3614.306 kb on + strand, within Rv3238cat 3614.307 kb on - strand, within Rv3238cat 3614.352 kb on - strandat 3614.352 kb on - strandat 3614.358 kb on + strandat 3614.359 kb on - strandat 3614.359 kb on - strandat 3614.715 kb on + strandat 3614.716 kb on - strandat 3614.716 kb on - strandat 3614.781 kb on + strand, within Rv3239cat 3614.816 kb on - strand, within Rv3239cat 3614.830 kb on + strand, within Rv3239cat 3614.830 kb on + strand, within Rv3239cat 3614.831 kb on - strand, within Rv3239cat 3614.831 kb on - strand, within Rv3239cat 3614.831 kb on - strand, within Rv3239cat 3614.979 kb on + strand, within Rv3239cat 3614.980 kb on - strand, within Rv3239cat 3614.983 kb on - strand, within Rv3239cat 3615.032 kb on - strand, within Rv3239cat 3615.061 kb on + strand, within Rv3239cat 3615.067 kb on + strand, within Rv3239cat 3615.067 kb on + strand, within Rv3239cat 3615.067 kb on + strand, within Rv3239cat 3615.068 kb on - strand, within Rv3239cat 3615.073 kb on + strand, within Rv3239cat 3615.234 kb on + strand, within Rv3239c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethambutol 0.75 ug/mL
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3,612,741 - Rv3236c 0.68 -0.6
3,613,288 + Rv3237c 0.35 -0.1
3,613,289 - Rv3237c 0.35 -0.7
3,613,319 - Rv3237c 0.41 -0.7
3,613,319 - Rv3237c 0.41 -0.2
3,613,486 - Rv3237c 0.76 -0.4
3,613,546 - Rv3237c 0.88 +0.7
3,613,561 - +0.1
3,613,603 + +1.2
3,613,603 + +0.6
3,613,603 + +0.0
3,613,603 + +0.1
3,613,636 + -0.1
3,613,636 + +0.4
3,613,669 + -0.4
3,613,669 + -0.2
3,613,670 - -0.2
3,613,745 + Rv3238c 0.11 +0.4
3,613,745 + Rv3238c 0.11 +0.1
3,613,783 - Rv3238c 0.16 -0.0
3,613,921 - Rv3238c 0.35 -0.2
3,613,944 + Rv3238c 0.38 +0.1
3,613,944 + Rv3238c 0.38 +0.4
3,613,945 - Rv3238c 0.38 -0.1
3,613,945 - Rv3238c 0.38 +1.9
3,613,955 + Rv3238c 0.40 +0.4
3,613,956 - Rv3238c 0.40 +0.8
3,614,101 - Rv3238c 0.59 -0.1
3,614,101 - Rv3238c 0.59 +0.2
3,614,132 + Rv3238c 0.64 -0.4
3,614,132 + Rv3238c 0.64 -0.2
3,614,132 + Rv3238c 0.64 +0.1
3,614,133 - Rv3238c 0.64 +0.6
3,614,133 - Rv3238c 0.64 +0.4
3,614,133 - Rv3238c 0.64 +1.9
3,614,133 - Rv3238c 0.64 -0.8
3,614,136 + Rv3238c 0.64 -0.1
3,614,136 + Rv3238c 0.64 -0.4
3,614,136 + Rv3238c 0.64 -0.8
3,614,136 + Rv3238c 0.64 +0.3
3,614,137 - Rv3238c 0.64 -0.1
3,614,137 - Rv3238c 0.64 +1.9
3,614,137 - Rv3238c 0.64 -1.2
3,614,137 - Rv3238c 0.64 -0.3
3,614,137 - Rv3238c 0.64 +0.6
3,614,137 - Rv3238c 0.64 -0.2
3,614,137 - Rv3238c 0.64 -1.7
3,614,137 - Rv3238c 0.64 +0.1
3,614,209 + Rv3238c 0.74 -0.1
3,614,209 + Rv3238c 0.74 +1.2
3,614,210 - Rv3238c 0.74 -0.7
3,614,288 + Rv3238c 0.85 +0.3
3,614,306 + Rv3238c 0.87 -0.3
3,614,306 + Rv3238c 0.87 -0.1
3,614,307 - Rv3238c 0.87 +0.1
3,614,352 - +2.3
3,614,352 - -0.1
3,614,358 + +0.6
3,614,359 - -0.9
3,614,359 - +0.2
3,614,715 + -0.1
3,614,716 - -0.2
3,614,716 - +0.9
3,614,781 + Rv3239c 0.10 +1.9
3,614,816 - Rv3239c 0.11 -0.9
3,614,830 + Rv3239c 0.12 +0.8
3,614,830 + Rv3239c 0.12 +0.3
3,614,831 - Rv3239c 0.12 -1.2
3,614,831 - Rv3239c 0.12 -0.3
3,614,831 - Rv3239c 0.12 -0.6
3,614,979 + Rv3239c 0.17 -0.4
3,614,980 - Rv3239c 0.17 -0.6
3,614,983 - Rv3239c 0.17 +0.3
3,615,032 - Rv3239c 0.18 -0.8
3,615,061 + Rv3239c 0.19 -0.3
3,615,067 + Rv3239c 0.19 +1.1
3,615,067 + Rv3239c 0.19 +1.9
3,615,067 + Rv3239c 0.19 -0.5
3,615,068 - Rv3239c 0.19 -0.5
3,615,073 + Rv3239c 0.20 +0.3
3,615,234 + Rv3239c 0.25 -0.1

Or see this region's nucleotide sequence