Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2453c

Experiment: 7H9 with Ethambutol 0.75 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2450c and Rv2451 are separated by 81 nucleotidesRv2451 and Rv2452c are separated by 187 nucleotidesRv2452c and Rv2453c are separated by 23 nucleotidesRv2453c and Rv2454c are separated by 1 nucleotides Rv2450c: Rv2450c - Probable resuscitation-promoting factor RpfE, at 2,751,662 to 2,752,180 Rv2450c Rv2451: Rv2451 - Hypothetical proline and serine rich protein, at 2,752,262 to 2,752,660 Rv2451 Rv2452c: Rv2452c - Hypothetical protein, at 2,752,848 to 2,752,994 Rv2452c Rv2453c: Rv2453c - Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA, at 2,753,018 to 2,753,623 Rv2453c Rv2454c: Rv2454c - Probable oxidoreductase (beta subunit), at 2,753,625 to 2,754,746 Rv2454c Position (kb) 2753 2754Strain fitness (log2 ratio) -1 0 1at 2752.233 kb on + strandat 2752.390 kb on - strand, within Rv2451at 2752.447 kb on + strand, within Rv2451at 2752.479 kb on + strand, within Rv2451at 2752.483 kb on + strand, within Rv2451at 2752.563 kb on + strand, within Rv2451at 2752.563 kb on + strand, within Rv2451at 2752.563 kb on + strand, within Rv2451at 2752.564 kb on - strand, within Rv2451at 2752.744 kb on + strandat 2752.760 kb on + strandat 2752.760 kb on + strandat 2752.761 kb on - strandat 2752.782 kb on - strandat 2752.805 kb on + strandat 2752.922 kb on + strand, within Rv2452cat 2752.947 kb on + strand, within Rv2452cat 2752.947 kb on + strand, within Rv2452cat 2753.013 kb on + strandat 2753.190 kb on + strand, within Rv2453cat 2753.205 kb on + strand, within Rv2453cat 2753.206 kb on - strand, within Rv2453cat 2753.494 kb on + strand, within Rv2453cat 2753.494 kb on + strand, within Rv2453cat 2753.494 kb on + strand, within Rv2453cat 2753.495 kb on - strand, within Rv2453cat 2753.495 kb on - strand, within Rv2453cat 2753.495 kb on - strand, within Rv2453cat 2753.495 kb on - strand, within Rv2453cat 2753.495 kb on - strand, within Rv2453cat 2753.495 kb on - strand, within Rv2453c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethambutol 0.75 ug/mL
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2,752,233 + -0.0
2,752,390 - Rv2451 0.32 -0.2
2,752,447 + Rv2451 0.46 -0.7
2,752,479 + Rv2451 0.54 +0.4
2,752,483 + Rv2451 0.55 -0.6
2,752,563 + Rv2451 0.75 -0.7
2,752,563 + Rv2451 0.75 -0.3
2,752,563 + Rv2451 0.75 +0.3
2,752,564 - Rv2451 0.76 +0.6
2,752,744 + -0.5
2,752,760 + -0.5
2,752,760 + +0.9
2,752,761 - -0.2
2,752,782 - -0.3
2,752,805 + -0.8
2,752,922 + Rv2452c 0.50 -0.8
2,752,947 + Rv2452c 0.67 -0.2
2,752,947 + Rv2452c 0.67 -0.4
2,753,013 + -0.1
2,753,190 + Rv2453c 0.28 -0.2
2,753,205 + Rv2453c 0.31 +0.1
2,753,206 - Rv2453c 0.31 -0.3
2,753,494 + Rv2453c 0.79 -0.2
2,753,494 + Rv2453c 0.79 +0.7
2,753,494 + Rv2453c 0.79 +0.5
2,753,495 - Rv2453c 0.79 +0.1
2,753,495 - Rv2453c 0.79 -0.6
2,753,495 - Rv2453c 0.79 -0.4
2,753,495 - Rv2453c 0.79 +0.2
2,753,495 - Rv2453c 0.79 +0.6
2,753,495 - Rv2453c 0.79 +0.1

Or see this region's nucleotide sequence