Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3664c

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3663c and Rv3664c overlap by 4 nucleotidesRv3664c and Rv3665c are separated by 55 nucleotidesRv3665c and Rv3666c are separated by 1 nucleotides Rv3663c: Rv3663c - Probable dipeptide-transport ATP-binding protein ABC transporter DppD, at 4,102,032 to 4,103,678 Rv3663c Rv3664c: Rv3664c - Probable dipeptide-transport integral membrane protein ABC transporter DppC, at 4,103,675 to 4,104,475 Rv3664c Rv3665c: Rv3665c - Probable dipeptide-transport integral membrane protein ABC transporter DppB, at 4,104,531 to 4,105,457 Rv3665c Rv3666c: Rv3666c - Probable periplasmic dipeptide-binding lipoprotein DppA, at 4,105,459 to 4,107,084 Rv3666c Position (kb) 4103 4104 4105Strain fitness (log2 ratio) -1 0 1at 4103.055 kb on + strand, within Rv3663cat 4103.395 kb on + strand, within Rv3663cat 4104.213 kb on + strand, within Rv3664cat 4104.303 kb on + strand, within Rv3664cat 4104.397 kb on - strandat 4104.482 kb on - strandat 4104.482 kb on - strandat 4105.447 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL
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4,103,055 + Rv3663c 0.62 +0.0
4,103,395 + Rv3663c 0.83 +0.2
4,104,213 + Rv3664c 0.67 -1.3
4,104,303 + Rv3664c 0.78 -0.8
4,104,397 - -0.7
4,104,482 - -0.2
4,104,482 - -0.4
4,105,447 + -0.8

Or see this region's nucleotide sequence