Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2332

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
2,604,307	+				+0.5
2,604,642	+		Rv2331	0.89	+0.3
2,604,642	+		Rv2331	0.89	+1.8
2,604,642	+		Rv2331	0.89	-0.5
2,604,642	+		Rv2331	0.89	+0.9
2,604,643	-		Rv2331	0.89	-0.0
2,604,643	-		Rv2331	0.89	-0.0
2,604,660	+				+0.8
2,604,739	+				+1.1
2,604,739	+				-0.8
2,604,754	-				-0.8
2,604,754	-				+0.3
2,604,786	-		Rv2331A	0.14	+0.2
2,605,059	-				+0.0
2,605,262	+				-0.4
2,605,345	+		Rv2332	0.14	-0.3
2,605,345	+		Rv2332	0.14	-0.1
2,605,346	-		Rv2332	0.14	-0.0
2,605,394	-		Rv2332	0.17	-0.1
2,605,438	+		Rv2332	0.20	+0.8
2,605,439	-		Rv2332	0.20	-0.5
2,605,439	-		Rv2332	0.20	-1.0
2,605,718	-		Rv2332	0.37	-1.2
2,605,718	-		Rv2332	0.37	-0.3
2,605,779	+		Rv2332	0.41	+0.4
2,605,860	-		Rv2332	0.46	-0.2
2,605,867	+		Rv2332	0.46	-1.8
2,605,867	+		Rv2332	0.46	+0.2
2,605,868	-		Rv2332	0.46	-2.2
2,605,868	-		Rv2332	0.46	-0.1
2,605,868	-		Rv2332	0.46	-0.6
2,605,868	-		Rv2332	0.46	-0.4
2,605,880	-		Rv2332	0.47	+0.1
2,605,935	-		Rv2332	0.50	-1.0
2,605,936	+		Rv2332	0.50	-0.1
2,605,982	+		Rv2332	0.53	+0.1
2,605,982	+		Rv2332	0.53	-2.3
2,605,983	-		Rv2332	0.53	-0.1
2,605,983	-		Rv2332	0.53	-0.2
2,605,983	-		Rv2332	0.53	-0.2
2,606,153	-		Rv2332	0.63	-0.4
2,606,236	-		Rv2332	0.68	-0.4
2,606,236	-		Rv2332	0.68	-0.2
2,606,449	+		Rv2332	0.81	-0.1
2,606,450	-		Rv2332	0.81	-1.4
2,606,529	-		Rv2332	0.86	-0.3
2,606,747	-				-0.4
2,606,780	-				+0.0
2,606,795	+				+0.3
2,606,795	+				-0.3
2,606,796	-				-0.2
2,607,443	-		Rv2333c	0.46	+0.3
2,607,444	+		Rv2333c	0.46	-0.5
2,607,445	-		Rv2333c	0.46	+1.8
2,607,492	+		Rv2333c	0.49	-0.5
2,607,492	+		Rv2333c	0.49	+0.1
2,607,537	+		Rv2333c	0.51	-0.1
2,607,690	+		Rv2333c	0.61	+0.3
2,607,691	-		Rv2333c	0.61	-0.2