Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1847

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
2,096,438	-		Rv1846c	0.61	+1.8
2,096,633	+				+0.2
2,096,643	+				+0.2
2,096,644	-				+0.3
2,096,644	-				-3.4
2,096,644	-				-0.3
2,096,689	+				-0.2
2,096,689	+				-1.2
2,096,689	+				+0.1
2,096,690	-				+1.8
2,096,690	-				-0.2
2,096,690	-				+1.8
2,096,690	-				-0.3
2,096,711	+				-0.5
2,096,712	-				-0.9
2,096,864	+				-0.4
2,096,865	-				-0.1
2,097,040	-		Rv1847	0.39	-1.1
2,097,131	+		Rv1847	0.60	-0.5
2,097,131	+		Rv1847	0.60	-0.7
2,097,131	+		Rv1847	0.60	+0.0
2,097,132	-		Rv1847	0.60	+0.1
2,097,172	-		Rv1847	0.70	-0.6
2,097,172	-		Rv1847	0.70	-0.3
2,097,172	-		Rv1847	0.70	-0.3
2,097,172	-		Rv1847	0.70	-1.0
2,097,986	-				-0.2
2,097,998	-				-0.5
2,098,005	+				+0.2
2,098,005	+				+0.3
2,098,006	-				-0.4