Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1236

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
1,378,198	+		Rv1235	0.48	+0.9
1,378,256	-		Rv1235	0.52	+0.2
1,378,664	+		Rv1235	0.81	-0.3
1,378,665	-		Rv1235	0.81	+0.3
1,378,665	-		Rv1235	0.81	+0.5
1,379,066	-		Rv1236	0.15	+0.2
1,379,079	+		Rv1236	0.16	+0.7
1,379,140	+		Rv1236	0.23	-0.8
1,379,140	+		Rv1236	0.23	-0.1
1,379,140	+		Rv1236	0.23	-1.2
1,379,141	-		Rv1236	0.23	-1.4
1,379,141	-		Rv1236	0.23	+0.6
1,379,165	-		Rv1236	0.26	-0.9
1,379,335	+		Rv1236	0.44	+1.3
1,379,337	+		Rv1236	0.44	-1.6
1,379,338	-		Rv1236	0.44	-0.1
1,379,338	-		Rv1236	0.44	-0.5
1,379,348	-		Rv1236	0.46	+1.9
1,379,348	-		Rv1236	0.46	-0.1
1,379,473	-		Rv1236	0.59	-0.4
1,379,656	+		Rv1236	0.79	-0.4
1,379,657	-		Rv1236	0.79	-0.4
1,379,657	-		Rv1236	0.79	-0.3
1,379,657	-		Rv1236	0.79	-0.1
1,380,011	+		Rv1237	0.19	-0.0
1,380,011	+		Rv1237	0.19	-0.4
1,380,011	+		Rv1237	0.19	+0.5
1,380,012	-		Rv1237	0.19	-0.1
1,380,305	+		Rv1237	0.55	+0.2
1,380,306	-		Rv1237	0.55	-0.4
1,380,827	+		Rv1238	0.12	+0.8