Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1159

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
1,284,426	-		Rv1158c	0.36	-0.3
1,284,510	-		Rv1158c	0.48	-1.3
1,284,551	+		Rv1158c	0.54	-0.3
1,284,801	-				+0.3
1,284,801	-				-0.6
1,284,943	-				-1.1
1,284,943	-				-0.7
1,284,953	+				-1.0
1,285,050	+				-0.3
1,285,050	+				-0.2
1,285,050	+				+0.1
1,285,253	+		Rv1159	0.20	-0.7
1,285,381	-		Rv1159	0.30	+0.9
1,285,381	-		Rv1159	0.30	-4.3
1,285,754	+		Rv1159	0.59	-2.2
1,285,902	+		Rv1159	0.70	-2.9
1,286,252	+				-0.1
1,286,252	+				-0.2
1,286,253	-				+1.0
1,286,253	-				-0.1
1,286,285	+				-0.3
1,286,285	+				-0.5
1,286,413	+		Rv1159A	0.45	-0.4
1,286,413	+		Rv1159A	0.45	-1.0
1,286,558	-				-0.5
1,286,568	+				+0.0
1,286,569	-				+0.7
1,286,579	+				+0.1
1,286,581	+				-0.3
1,286,582	-				-0.4
1,286,848	-		Rv1160	0.59	-0.9
1,286,941	+		Rv1160	0.81	+0.5
1,287,112	+				+0.2