Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1088

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
1,213,593	+		Rv1087	0.88	-0.4
1,213,862	-				-0.6
1,213,862	-				-1.3
1,213,946	-				-0.6
1,213,946	-				-0.6
1,213,946	-				-0.6
1,213,946	-				-0.8
1,213,948	+				-0.3
1,213,949	-				-0.3
1,213,949	-				-1.2
1,213,949	-				-1.7
1,213,949	-				-0.7
1,213,949	-				-0.9
1,214,093	-		Rv1087A	0.17	-0.1
1,214,093	-		Rv1087A	0.17	-1.0
1,214,118	-		Rv1087A	0.24	-0.7
1,214,118	-		Rv1087A	0.24	-0.2
1,214,238	+		Rv1087A	0.62	-0.3
1,214,238	+		Rv1087A	0.62	-0.9
1,214,238	+		Rv1087A	0.62	-0.2
1,214,239	-		Rv1087A	0.62	-0.0
1,214,239	-		Rv1087A	0.62	-0.4
1,214,239	-		Rv1087A	0.62	-0.5
1,214,239	-		Rv1087A	0.62	+0.9
1,214,239	-		Rv1087A	0.62	-1.2
1,214,244	-		Rv1087A	0.64	-1.8
1,214,266	-		Rv1087A	0.70	-1.0
1,214,519	+				-0.8
1,214,520	-				-0.6
1,214,587	+		Rv1088	0.17	-0.9
1,214,696	+		Rv1088	0.42	-0.9
1,214,696	+		Rv1088	0.42	+1.5
1,214,696	+		Rv1088	0.42	-0.8
1,214,696	+		Rv1088	0.42	+0.3
1,214,696	+		Rv1088	0.42	-0.6
1,215,066	+		Rv1089	0.82	+0.3
1,215,188	-				-1.4
1,215,209	+				-0.8
1,215,210	-				-1.8
1,215,210	-				-1.0
1,215,210	-				-0.2
1,215,210	-				-0.2
1,215,405	+				-0.6
1,215,406	-				-0.6
1,215,419	+				-0.6
1,215,435	+				-0.7
1,215,435	+				-0.7
1,215,436	-				-0.4
1,215,659	+		Rv1090	0.13	-0.9
1,215,659	+		Rv1090	0.13	-1.2
1,215,660	-		Rv1090	0.13	-1.0
1,215,665	+		Rv1090	0.14	-0.9
1,215,665	+		Rv1090	0.14	-0.6
1,215,666	-		Rv1090	0.15	-0.0
1,215,666	-		Rv1090	0.15	-1.0
1,215,681	+		Rv1090	0.18	-1.4
1,215,682	-		Rv1090	0.18	-0.9
1,215,695	+		Rv1090	0.21	+0.2
1,215,695	+		Rv1090	0.21	+0.9
1,215,696	-		Rv1090	0.21	-0.9
1,215,696	-		Rv1090	0.21	-1.0
1,215,875	+		Rv1090	0.61	-1.3
1,215,875	+		Rv1090	0.61	-1.2
1,215,876	-		Rv1090	0.61	+0.4
1,215,876	-		Rv1090	0.61	-0.6
1,215,876	-		Rv1090	0.61	-0.9
1,215,876	-		Rv1090	0.61	-0.1