Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0977

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
1,089,784	+		Rv0976c	0.77	-0.2
1,090,078	+				+2.3
1,090,079	-				-0.1
1,090,093	+				+0.2
1,090,147	+				+0.2
1,090,315	+				-1.3
1,090,315	+				-0.2
1,090,544	+				-0.8
1,090,545	-				-1.1
1,090,545	-				-0.5
1,090,556	+				+1.2
1,090,631	+				-0.9
1,090,631	+				-0.5
1,090,632	-				-0.3
1,090,632	-				-0.8
1,090,632	-				-0.5
1,091,014	-		Rv0977	0.23	-0.1
1,091,422	+		Rv0977	0.38	+1.4
1,091,700	-		Rv0977	0.48	-2.3
1,092,059	+		Rv0977	0.61	+0.2
1,092,214	+		Rv0977	0.66	-1.1
1,092,214	+		Rv0977	0.66	+1.9
1,092,368	-		Rv0977	0.72	-0.5
1,092,384	+		Rv0977	0.73	-0.6
1,092,384	+		Rv0977	0.73	-1.5
1,092,385	-		Rv0977	0.73	-0.4
1,092,385	-		Rv0977	0.73	+0.7
1,092,385	-		Rv0977	0.73	-0.1
1,092,385	-		Rv0977	0.73	+0.0
1,092,397	-		Rv0977	0.73	-0.3
1,092,397	-		Rv0977	0.73	-1.0
1,092,530	+		Rv0977	0.78	-1.3
1,092,530	+		Rv0977	0.78	-0.2
1,092,531	-		Rv0977	0.78	-0.7
1,092,531	-		Rv0977	0.78	+0.1
1,092,531	-		Rv0977	0.78	+1.1
1,092,531	-		Rv0977	0.78	-0.6
1,092,531	-		Rv0977	0.78	-0.7
1,092,531	-		Rv0977	0.78	-2.2
1,092,536	+		Rv0977	0.78	-1.3
1,092,537	-		Rv0977	0.78	-0.5
1,092,546	-		Rv0977	0.78	-0.4
1,092,546	-		Rv0977	0.78	-0.4
1,092,546	-		Rv0977	0.78	-0.1
1,092,546	-		Rv0977	0.78	+0.1
1,092,546	-		Rv0977	0.78	+1.3
1,092,546	-		Rv0977	0.78	+0.5
1,092,598	+		Rv0977	0.80	-1.1
1,092,639	-		Rv0977	0.82	-0.4
1,092,795	+		Rv0977	0.87	-0.2
1,092,806	-		Rv0977	0.88	-0.6
1,092,978	-				-0.2
1,093,004	+				-0.6
1,093,004	+				-0.4
1,093,004	+				-1.2
1,093,005	-				-0.5
1,093,005	-				+0.2
1,093,005	-				-0.3
1,093,096	-				+0.3
1,093,097	+				-0.3
1,093,097	+				-0.3
1,093,097	+				-0.5
1,093,097	+				+1.5
1,093,097	+				-1.8
1,093,097	+				-1.1
1,093,098	-				-0.4
1,093,098	-				-0.6
1,093,098	-				+0.3
1,093,106	+				+0.7
1,093,106	+				-0.9
1,093,106	+				-0.5
1,093,138	+				-0.3
1,093,138	+				-0.8
1,093,138	+				-0.6
1,093,139	-				-0.2
1,093,139	-				-0.3
1,093,139	-				+0.1
1,093,167	-				+0.5
1,093,232	+				-1.0
1,093,233	-				-0.9
1,093,370	+				-0.1
1,093,404	+				+0.2
1,093,404	+				+2.7
1,093,404	+				+0.1
1,093,404	+				-0.5
1,093,405	-				-0.8
1,093,405	-				-0.1
1,093,663	-		Rv0978c	0.30	+0.1
1,093,663	-		Rv0978c	0.30	-0.1
1,093,663	-		Rv0978c	0.30	-0.2