Experiment: 7H9 with Bedaquiline 0.15 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0750 and Rv0751c are separated by 68 nucleotides Rv0751c and Rv0752c are separated by 10 nucleotides Rv0752c and Rv0753c are separated by 6 nucleotides
Rv0750: Rv0750 - Conserved hypothetical protein, at 842,033 to 842,278
Rv0750
Rv0751c: Rv0751c - Probable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh), at 842,347 to 843,231
Rv0751c
Rv0752c: Rv0752c - Probable acyl-CoA dehydrogenase FadE9, at 843,242 to 844,414
Rv0752c
Rv0753c: Rv0753c - Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH), at 844,421 to 845,953
Rv0753c
Position (kb) 843
844
845 Strain fitness (log2 ratio) -2
-1
0
1
2 at 842.348 kb on + strand at 842.791 kb on + strand, within Rv0751c at 843.008 kb on + strand, within Rv0751c at 843.008 kb on + strand, within Rv0751c at 843.211 kb on + strand at 843.211 kb on + strand at 843.212 kb on - strand at 843.243 kb on + strand at 843.372 kb on + strand, within Rv0752c at 843.912 kb on + strand, within Rv0752c at 843.912 kb on + strand, within Rv0752c at 843.913 kb on - strand, within Rv0752c at 844.257 kb on + strand, within Rv0752c at 844.779 kb on + strand, within Rv0753c at 844.780 kb on - strand, within Rv0753c at 844.944 kb on + strand, within Rv0753c at 845.030 kb on - strand, within Rv0753c at 845.250 kb on + strand, within Rv0753c at 845.257 kb on - strand, within Rv0753c at 845.257 kb on - strand, within Rv0753c
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL remove 842,348 + -0.9 842,791 + Rv0751c 0.50 +0.3 843,008 + Rv0751c 0.75 -0.8 843,008 + Rv0751c 0.75 -0.6 843,211 + -0.4 843,211 + -0.5 843,212 - -0.2 843,243 + -1.8 843,372 + Rv0752c 0.11 -0.3 843,912 + Rv0752c 0.57 -1.0 843,912 + Rv0752c 0.57 +0.2 843,913 - Rv0752c 0.57 -0.2 844,257 + Rv0752c 0.87 -0.4 844,779 + Rv0753c 0.23 -0.1 844,780 - Rv0753c 0.23 +0.3 844,944 + Rv0753c 0.34 -0.6 845,030 - Rv0753c 0.40 -0.0 845,250 + Rv0753c 0.54 -0.3 845,257 - Rv0753c 0.55 -1.5 845,257 - Rv0753c 0.55 +1.8
Or see this region's nucleotide sequence