Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3128c

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3127 and Rv3128c overlap by 14 nucleotidesRv3128c and Rv3129 are separated by 478 nucleotidesRv3129 and Rv3130c overlap by 18 nucleotides Rv3127: Rv3127 - Conserved protein, at 3,492,147 to 3,493,181 Rv3127 Rv3128c: Rv3128c - Conserved hypothetical protein, at 3,493,168 to 3,494,181 Rv3128c Rv3129: Rv3129 - Conserved hypothetical protein, at 3,494,660 to 3,494,992 Rv3129 Rv3130c: Rv3130c - Triacylglycerol synthase (diacylglycerol acyltransferase) Tgs1, at 3,494,975 to 3,496,366 Rv3130c Position (kb) 3493 3494 3495Strain fitness (log2 ratio) -1 0 1 2at 3492.525 kb on + strand, within Rv3127at 3492.793 kb on - strand, within Rv3127at 3492.815 kb on - strand, within Rv3127at 3492.907 kb on + strand, within Rv3127at 3493.130 kb on + strandat 3493.143 kb on - strandat 3493.232 kb on + strandat 3493.233 kb on - strandat 3493.328 kb on + strand, within Rv3128cat 3493.559 kb on + strand, within Rv3128cat 3493.637 kb on + strand, within Rv3128cat 3493.638 kb on - strand, within Rv3128cat 3493.642 kb on - strand, within Rv3128cat 3494.213 kb on + strandat 3494.214 kb on - strandat 3494.382 kb on - strandat 3494.476 kb on + strandat 3494.476 kb on + strandat 3494.477 kb on - strandat 3495.121 kb on - strand, within Rv3130cat 3495.136 kb on - strand, within Rv3130c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL
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3,492,525 + Rv3127 0.37 -0.0
3,492,793 - Rv3127 0.62 +0.1
3,492,815 - Rv3127 0.65 -0.4
3,492,907 + Rv3127 0.73 -0.3
3,493,130 + +0.9
3,493,143 - +0.5
3,493,232 + -0.1
3,493,233 - +1.4
3,493,328 + Rv3128c 0.16 -0.1
3,493,559 + Rv3128c 0.39 -0.4
3,493,637 + Rv3128c 0.46 +1.9
3,493,638 - Rv3128c 0.46 +1.0
3,493,642 - Rv3128c 0.47 +0.8
3,494,213 + -1.3
3,494,214 - +0.9
3,494,382 - -0.7
3,494,476 + -0.3
3,494,476 + +0.6
3,494,477 - -1.2
3,495,121 - Rv3130c 0.10 -0.2
3,495,136 - Rv3130c 0.12 -0.2

Or see this region's nucleotide sequence