Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3045

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
3,406,213	+				+1.9
3,406,213	+				-0.5
3,406,213	+				-0.2
3,406,229	+				-0.9
3,406,453	+		Rv3045	0.16	-1.0
3,406,454	-		Rv3045	0.16	-1.3
3,406,702	+		Rv3045	0.40	-1.2
3,406,775	-		Rv3045	0.47	-0.3
3,406,948	+		Rv3045	0.64	-0.6
3,406,951	+		Rv3045	0.64	-1.1
3,407,249	-				-1.3
3,407,249	-				-1.2
3,407,249	-				-0.1
3,407,263	+				-2.5
3,407,578	+		Rv3046c	0.70	-0.4
3,407,878	+				+0.2
3,407,879	-				+0.3
3,408,051	+		Rv3047c	0.10	+0.2
3,408,051	+		Rv3047c	0.10	-0.4
3,408,052	-		Rv3047c	0.11	-0.1
3,408,052	-		Rv3047c	0.11	-0.1
3,408,127	+		Rv3047c	0.37	-1.0
3,408,128	-		Rv3047c	0.37	-0.4
3,408,211	+		Rv3047c	0.66	+0.0