Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2857c

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2856 and Rv2857c are separated by 780 nucleotidesRv2857c and Rv2858c overlap by 4 nucleotides Rv2856: Rv2856 - Possible nickel-transport integral membrane protein NicT, at 3,166,684 to 3,167,802 Rv2856 Rv2857c: Rv2857c - Probable short-chain type dehydrogenase/reductase, at 3,168,583 to 3,169,359 Rv2857c Rv2858c: Rv2858c - Probable aldehyde dehydrogenase AldC, at 3,169,356 to 3,170,723 Rv2858c Position (kb) 3168 3169 3170Strain fitness (log2 ratio) -1 0 1 2at 3168.150 kb on - strandat 3168.282 kb on + strandat 3168.338 kb on + strandat 3168.339 kb on - strandat 3168.600 kb on - strandat 3168.668 kb on - strand, within Rv2857cat 3169.111 kb on + strand, within Rv2857cat 3169.198 kb on + strand, within Rv2857cat 3169.199 kb on - strand, within Rv2857cat 3169.774 kb on + strand, within Rv2858cat 3169.775 kb on - strand, within Rv2858c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL
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3,168,150 - -0.4
3,168,282 + +0.4
3,168,338 + -1.2
3,168,339 - +1.9
3,168,600 - +1.0
3,168,668 - Rv2857c 0.11 -0.7
3,169,111 + Rv2857c 0.68 -0.1
3,169,198 + Rv2857c 0.79 -0.2
3,169,199 - Rv2857c 0.79 +0.4
3,169,774 + Rv2858c 0.31 -0.3
3,169,775 - Rv2858c 0.31 +1.0

Or see this region's nucleotide sequence