Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2762c

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2761c and Rv2762c overlap by 4 nucleotidesRv2762c and Rv2763c are separated by 73 nucleotidesRv2763c and Rv2764c are separated by 70 nucleotides Rv2761c: Rv2761c - Possible type I restriction/modification system specificity determinant HsdS (S protein), at 3,071,546 to 3,072,640 Rv2761c Rv2762c: Rv2762c - Conserved hypothetical protein, at 3,072,637 to 3,073,056 Rv2762c Rv2763c: Rv2763c - Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase), at 3,073,130 to 3,073,609 Rv2763c Rv2764c: Rv2764c - Probable thymidylate synthase ThyA (ts) (TSASE), at 3,073,680 to 3,074,471 Rv2764c Position (kb) 3072 3073 3074Strain fitness (log2 ratio) -2 -1 0 1at 3072.039 kb on + strand, within Rv2761cat 3072.040 kb on - strand, within Rv2761cat 3072.117 kb on + strand, within Rv2761cat 3072.118 kb on - strand, within Rv2761cat 3072.118 kb on - strand, within Rv2761cat 3072.118 kb on - strand, within Rv2761cat 3072.345 kb on + strand, within Rv2761cat 3072.346 kb on - strand, within Rv2761cat 3072.441 kb on + strand, within Rv2761cat 3072.523 kb on - strand, within Rv2761cat 3072.574 kb on + strandat 3072.605 kb on + strandat 3072.611 kb on + strandat 3072.778 kb on + strand, within Rv2762c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL
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3,072,039 + Rv2761c 0.45 -0.3
3,072,040 - Rv2761c 0.45 -0.3
3,072,117 + Rv2761c 0.52 +1.3
3,072,118 - Rv2761c 0.52 -0.2
3,072,118 - Rv2761c 0.52 -0.3
3,072,118 - Rv2761c 0.52 -0.3
3,072,345 + Rv2761c 0.73 -0.1
3,072,346 - Rv2761c 0.73 +0.1
3,072,441 + Rv2761c 0.82 -2.6
3,072,523 - Rv2761c 0.89 -0.4
3,072,574 + +0.3
3,072,605 + +0.0
3,072,611 + +0.7
3,072,778 + Rv2762c 0.34 +0.3

Or see this region's nucleotide sequence