Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2598

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
2,926,022	+		Rv2596	0.71	-2.3
2,926,101	-				+0.0
2,926,286	+				+0.1
2,926,287	-				+0.8
2,926,291	+				-0.4
2,926,350	+				+0.7
2,926,350	+				-0.4
2,926,351	-				+1.2
2,926,351	-				-0.6
2,926,550	+		Rv2597	0.31	-0.3
2,926,550	+		Rv2597	0.31	-0.3
2,926,550	+		Rv2597	0.31	-0.5
2,926,550	+		Rv2597	0.31	-1.3
2,926,551	-		Rv2597	0.32	-0.2
2,926,551	-		Rv2597	0.32	-0.5
2,926,773	-		Rv2597	0.67	-0.7
2,926,773	-		Rv2597	0.67	+1.9
2,926,774	+		Rv2597	0.67	-2.2
2,926,774	+		Rv2597	0.67	+0.2
2,926,775	-		Rv2597	0.68	+0.3
2,926,949	+				+0.3
2,926,973	+				-0.4
2,926,973	+				+2.4
2,926,973	+				-0.5
2,927,023	+				-1.9
2,927,023	+				-0.1
2,927,023	+				-0.9
2,927,024	-				-0.3
2,927,024	-				+0.4
2,927,024	-				+1.5
2,927,236	-		Rv2598	0.51	-0.3
2,927,424	+		Rv2598	0.88	-1.5
2,927,579	+		Rv2599	0.24	-0.1
2,927,579	+		Rv2599	0.24	+2.5
2,927,580	-		Rv2599	0.24	+0.0
2,927,678	+		Rv2599	0.47	+0.4
2,927,679	-		Rv2599	0.47	-0.4
2,927,768	+		Rv2599	0.67	-0.2
2,927,768	+		Rv2599	0.67	-0.4
2,927,769	-		Rv2599	0.68	+0.8
2,927,769	-		Rv2599	0.68	-1.1
2,927,807	+		Rv2599	0.76	-1.7
2,927,809	+		Rv2599	0.77	-0.4
2,927,822	+		Rv2599	0.80	+0.3
2,927,822	+		Rv2599	0.80	+0.6
2,927,823	-		Rv2599	0.80	-0.7
2,927,823	-		Rv2599	0.80	-1.7
2,927,906	+				-0.9
2,927,907	-				-0.5
2,927,907	-				-0.6
2,927,907	-				-0.1
2,927,937	-				-2.1
2,927,937	-				-1.5
2,927,937	-				-0.3
2,927,940	-				-0.7
2,927,940	-				-0.4
2,928,009	-				+0.1
2,928,016	-				-0.4
2,928,087	+		Rv2600	0.24	-0.4
2,928,137	+		Rv2600	0.37	-1.9
2,928,137	+		Rv2600	0.37	-0.4
2,928,137	+		Rv2600	0.37	+0.0
2,928,137	+		Rv2600	0.37	-0.2
2,928,137	+		Rv2600	0.37	-0.5
2,928,138	-		Rv2600	0.37	-0.7
2,928,173	+		Rv2600	0.46	+1.0
2,928,173	+		Rv2600	0.46	-0.2
2,928,361	-				-0.1