Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2544

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
2,866,221	-				+0.7
2,866,221	-				-1.8
2,866,221	-				+0.2
2,866,221	-				-0.7
2,866,374	-				+0.1
2,866,406	+				+0.3
2,866,407	-				+1.4
2,866,541	+		Rv2543	0.11	+1.4
2,866,556	+		Rv2543	0.13	-0.2
2,866,655	-		Rv2543	0.28	-0.4
2,866,655	-		Rv2543	0.28	-0.3
2,866,760	+		Rv2543	0.44	+1.9
2,866,760	+		Rv2543	0.44	+0.4
2,866,760	+		Rv2543	0.44	-0.1
2,866,760	+		Rv2543	0.44	+0.2
2,866,761	-		Rv2543	0.44	+0.5
2,866,761	-		Rv2543	0.44	-0.4
2,866,761	-		Rv2543	0.44	-0.5
2,866,761	-		Rv2543	0.44	-1.0
2,866,810	-		Rv2543	0.52	-0.8
2,866,888	-		Rv2543	0.64	+0.3
2,866,912	+		Rv2543	0.67	-0.4
2,866,963	+		Rv2543	0.75	-0.2
2,867,197	+		Rv2544	0.11	-2.1
2,867,212	+		Rv2544	0.13	-0.4
2,867,311	-		Rv2544	0.28	-1.6
2,867,678	+		Rv2544	0.84	-1.9
2,867,679	-		Rv2544	0.84	+0.1
2,867,880	+		Rv2545	0.35	-0.9
2,867,907	+		Rv2545	0.44	-0.5
2,867,907	+		Rv2545	0.44	-0.6
2,867,907	+		Rv2545	0.44	-1.1
2,867,907	+		Rv2545	0.44	-0.4
2,867,907	+		Rv2545	0.44	+1.3
2,867,907	+		Rv2545	0.44	-0.2
2,867,907	+		Rv2545	0.44	-0.5
2,867,907	+		Rv2545	0.44	-0.6
2,867,907	+		Rv2545	0.44	-0.5
2,867,908	-		Rv2545	0.45	-0.2
2,867,910	-		Rv2545	0.46	-1.3
2,867,928	+		Rv2545	0.52	+0.3
2,867,928	+		Rv2545	0.52	-0.4
2,867,928	+		Rv2545	0.52	-0.2
2,867,928	+		Rv2545	0.52	+0.1
2,867,929	-		Rv2545	0.52	+0.2
2,867,930	+		Rv2545	0.53	+0.6
2,867,931	-		Rv2545	0.53	+0.4
2,867,976	+		Rv2545	0.69	+0.4
2,867,976	+		Rv2545	0.69	+0.6
2,867,977	-		Rv2545	0.70	-0.3
2,867,977	-		Rv2545	0.70	-0.3
2,867,977	-		Rv2545	0.70	+3.5
2,867,977	-		Rv2545	0.70	+1.9
2,867,977	-		Rv2545	0.70	-0.3
2,867,977	-		Rv2545	0.70	-0.5
2,868,007	+		Rv2545	0.80	-0.1
2,868,305	-		Rv2546	0.36	-0.5
2,868,305	-		Rv2546	0.36	+0.1
2,868,305	-		Rv2546	0.36	+0.9
2,868,343	-		Rv2546	0.46	+0.8
2,868,344	+		Rv2546	0.46	-0.5
2,868,345	-		Rv2546	0.46	-0.1
2,868,502	+		Rv2546	0.84	+0.3
2,868,502	+		Rv2546	0.84	+1.9
2,868,502	+		Rv2546	0.84	-0.6
2,868,502	+		Rv2546	0.84	+0.7
2,868,503	-		Rv2546	0.84	+0.1
2,868,503	-		Rv2546	0.84	-0.3
2,868,534	+				-1.4
2,868,534	+				-0.2
2,868,534	+				+0.4
2,868,594	+				+0.4
2,868,594	+				+1.9