Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1775

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
2,008,417	+		Rv1774	0.44	+0.5
2,008,417	+		Rv1774	0.44	-0.4
2,008,462	+		Rv1774	0.47	-0.2
2,008,462	+		Rv1774	0.47	+0.4
2,008,706	-		Rv1774	0.65	-0.1
2,008,706	-		Rv1774	0.65	-0.8
2,008,708	-		Rv1774	0.65	-0.0
2,008,754	-		Rv1774	0.69	-0.3
2,008,786	-		Rv1774	0.71	-0.2
2,008,916	-		Rv1774	0.81	+0.0
2,008,916	-		Rv1774	0.81	+0.6
2,008,916	-		Rv1774	0.81	-0.1
2,008,917	+		Rv1774	0.81	-0.5
2,008,917	+		Rv1774	0.81	-0.8
2,008,918	-		Rv1774	0.81	-0.1
2,008,936	+		Rv1774	0.82	-0.5
2,008,936	+		Rv1774	0.82	+0.4
2,008,936	+		Rv1774	0.82	-1.9
2,008,937	-		Rv1774	0.82	-0.3
2,008,948	+		Rv1774	0.83	-0.6
2,008,985	-		Rv1774	0.86	-0.4
2,009,405	-		Rv1775	0.28	-0.9
2,009,578	-		Rv1775	0.50	-0.9
2,009,578	-		Rv1775	0.50	+0.9
2,009,608	-		Rv1775	0.53	-0.9
2,009,907	-		Rv1775	0.90	-1.6
2,009,919	+				-1.7
2,010,074	+		Rv1776c	0.14	-0.3
2,010,075	-		Rv1776c	0.14	-0.7
2,010,075	-		Rv1776c	0.14	-0.2
2,010,075	-		Rv1776c	0.14	+0.3
2,010,097	+		Rv1776c	0.18	+0.9
2,010,133	+		Rv1776c	0.25	+0.0
2,010,398	+		Rv1776c	0.72	+0.7
2,010,398	+		Rv1776c	0.72	-0.2
2,010,622	+				-0.2
2,010,634	-				-1.4
2,010,744	+				+0.9
2,010,745	-				+0.1
2,010,812	+		Rv1777	0.12	-0.5
2,010,867	-		Rv1777	0.16	-0.1
2,010,950	+		Rv1777	0.23	+0.6
2,010,950	+		Rv1777	0.23	-0.3
2,010,950	+		Rv1777	0.23	-0.0
2,010,950	+		Rv1777	0.23	-0.2
2,010,950	+		Rv1777	0.23	+0.5
2,010,951	-		Rv1777	0.23	+1.9
2,010,952	+		Rv1777	0.23	-0.5