Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1690

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1689 and Rv1690 are separated by 650 nucleotidesRv1690 and Rv1691 are separated by 38 nucleotidesRv1691 and Rv1692 overlap by 4 nucleotides Rv1689: Rv1689 - Probable tyrosyl-tRNA synthase TyrS (TYRRS), at 1,913,602 to 1,914,876 Rv1689 Rv1690: Rv1690 - Probable lipoprotein LprJ, at 1,915,527 to 1,915,910 Rv1690 Rv1691: Rv1691 - Conserved hypothetical protein, at 1,915,949 to 1,916,701 Rv1691 Rv1692: Rv1692 - Probable phosphatase, at 1,916,698 to 1,917,759 Rv1692 Position (kb) 1915 1916Strain fitness (log2 ratio) -1 0 1at 1914.919 kb on + strandat 1914.981 kb on + strandat 1914.981 kb on + strandat 1915.490 kb on + strandat 1915.832 kb on + strand, within Rv1690at 1915.833 kb on - strand, within Rv1690at 1915.915 kb on + strandat 1916.137 kb on - strand, within Rv1691at 1916.139 kb on + strand, within Rv1691at 1916.619 kb on + strand, within Rv1691at 1916.679 kb on + strandat 1916.844 kb on + strand, within Rv1692

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL
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1,914,919 + -0.2
1,914,981 + +1.4
1,914,981 + +0.2
1,915,490 + -1.3
1,915,832 + Rv1690 0.79 -1.6
1,915,833 - Rv1690 0.80 -1.0
1,915,915 + +0.0
1,916,137 - Rv1691 0.25 +0.5
1,916,139 + Rv1691 0.25 -0.1
1,916,619 + Rv1691 0.89 -0.2
1,916,679 + +0.4
1,916,844 + Rv1692 0.14 -0.1

Or see this region's nucleotide sequence