Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1679

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1678 and Rv1679 overlap by 1 nucleotidesRv1679 and Rv1680 are separated by 8 nucleotidesRv1680 and Rv1681 overlap by 4 nucleotides Rv1678: Rv1678 - Probable integral membrane protein, at 1,902,397 to 1,903,299 Rv1678 Rv1679: Rv1679 - Possible acyl-CoA dehydrogenase FadE16, at 1,903,299 to 1,904,420 Rv1679 Rv1680: Rv1680 - Hypothetical protein, at 1,904,429 to 1,905,253 Rv1680 Rv1681: Rv1681 - Possible molybdopterin biosynthesis protein MoeX, at 1,905,250 to 1,906,242 Rv1681 Position (kb) 1903 1904 1905Strain fitness (log2 ratio) -1 0 1at 1902.512 kb on - strand, within Rv1678at 1902.568 kb on + strand, within Rv1678at 1902.569 kb on - strand, within Rv1678at 1902.569 kb on - strand, within Rv1678at 1903.020 kb on - strand, within Rv1678at 1903.759 kb on - strand, within Rv1679at 1903.923 kb on + strand, within Rv1679at 1904.385 kb on + strandat 1904.565 kb on - strand, within Rv1680at 1904.817 kb on - strand, within Rv1680at 1905.070 kb on + strand, within Rv1680at 1905.089 kb on + strand, within Rv1680at 1905.258 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL
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1,902,512 - Rv1678 0.13 +0.3
1,902,568 + Rv1678 0.19 -0.7
1,902,569 - Rv1678 0.19 -0.7
1,902,569 - Rv1678 0.19 -0.6
1,903,020 - Rv1678 0.69 +0.7
1,903,759 - Rv1679 0.41 -0.4
1,903,923 + Rv1679 0.56 -0.3
1,904,385 + -0.2
1,904,565 - Rv1680 0.16 -0.1
1,904,817 - Rv1680 0.47 -0.6
1,905,070 + Rv1680 0.78 -1.4
1,905,089 + Rv1680 0.80 -0.2
1,905,258 - -0.1

Or see this region's nucleotide sequence