Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1428c

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Bedaquiline 0.15 ug/mL
1,603,392	+		Rv1427c	0.67	+0.2
1,603,392	+		Rv1427c	0.67	-0.5
1,603,505	-		Rv1427c	0.74	+0.5
1,603,922	+				+0.9
1,603,922	+				-0.1
1,603,998	+				-1.0
1,603,998	+				-0.5
1,603,999	-				-0.2
1,603,999	-				-0.4
1,604,064	+		Rv1428c	0.16	-1.5
1,604,064	+		Rv1428c	0.16	-0.3
1,604,218	+		Rv1428c	0.35	-1.0
1,604,218	+		Rv1428c	0.35	-0.4
1,604,218	+		Rv1428c	0.35	-0.8
1,604,219	-		Rv1428c	0.35	+1.3
1,604,219	-		Rv1428c	0.35	-0.7
1,604,293	+		Rv1428c	0.44	-0.7
1,604,525	-		Rv1428c	0.72	-0.4
1,604,641	+		Rv1428c	0.86	-0.8
1,604,642	-		Rv1428c	0.86	-0.2
1,604,642	-		Rv1428c	0.86	-0.7
1,604,642	-		Rv1428c	0.86	+1.9
1,604,670	+		Rv1428c	0.89	-1.0
1,604,671	-		Rv1428c	0.89	-2.0
1,604,808	-				-0.6
1,604,853	+				-0.4
1,604,923	-				+0.4
1,604,923	-				-0.1
1,604,995	+				-0.4
1,604,995	+				-0.3
1,605,144	+		Rv1429	0.21	-0.2
1,605,145	-		Rv1429	0.21	+0.4
1,605,145	-		Rv1429	0.21	-0.5
1,605,214	+		Rv1429	0.26	-0.3
1,605,214	+		Rv1429	0.26	+1.9
1,605,214	+		Rv1429	0.26	-0.2
1,605,215	-		Rv1429	0.27	-1.3
1,605,320	-		Rv1429	0.35	-0.7
1,605,470	+		Rv1429	0.47	-0.5