Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1107c

Experiment: 7H9 with Bedaquiline 0.15 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1106c and Rv1107c are separated by 9 nucleotidesRv1107c and Rv1108c overlap by 11 nucleotides Rv1106c: Rv1106c - 3-beta-hydroxysteroid dehydrogenase, at 1,232,844 to 1,233,956 Rv1106c Rv1107c: Rv1107c - Probable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit), at 1,233,966 to 1,234,223 Rv1107c Rv1108c: Rv1108c - Probable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit), at 1,234,213 to 1,235,460 Rv1108c Position (kb) 1233 1234 1235Strain fitness (log2 ratio) -2 -1 0 1at 1232.966 kb on - strand, within Rv1106cat 1233.013 kb on + strand, within Rv1106cat 1233.013 kb on + strand, within Rv1106cat 1233.094 kb on - strand, within Rv1106cat 1233.179 kb on + strand, within Rv1106cat 1233.180 kb on - strand, within Rv1106cat 1233.286 kb on + strand, within Rv1106cat 1233.286 kb on + strand, within Rv1106cat 1233.286 kb on + strand, within Rv1106cat 1233.287 kb on - strand, within Rv1106cat 1233.287 kb on - strand, within Rv1106cat 1233.287 kb on - strand, within Rv1106cat 1233.287 kb on - strand, within Rv1106cat 1233.484 kb on + strand, within Rv1106cat 1233.506 kb on + strand, within Rv1106cat 1233.507 kb on - strand, within Rv1106cat 1233.650 kb on + strand, within Rv1106cat 1233.651 kb on - strand, within Rv1106cat 1234.027 kb on - strand, within Rv1107cat 1234.154 kb on - strand, within Rv1107cat 1234.366 kb on + strand, within Rv1108cat 1234.366 kb on + strand, within Rv1108cat 1234.367 kb on - strand, within Rv1108c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL
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1,232,966 - Rv1106c 0.11 -2.3
1,233,013 + Rv1106c 0.15 -0.4
1,233,013 + Rv1106c 0.15 -0.2
1,233,094 - Rv1106c 0.22 -0.4
1,233,179 + Rv1106c 0.30 +0.2
1,233,180 - Rv1106c 0.30 +0.4
1,233,286 + Rv1106c 0.40 +0.4
1,233,286 + Rv1106c 0.40 -0.8
1,233,286 + Rv1106c 0.40 -0.3
1,233,287 - Rv1106c 0.40 -0.0
1,233,287 - Rv1106c 0.40 -0.2
1,233,287 - Rv1106c 0.40 +0.2
1,233,287 - Rv1106c 0.40 -0.8
1,233,484 + Rv1106c 0.58 -0.6
1,233,506 + Rv1106c 0.59 +0.1
1,233,507 - Rv1106c 0.60 +0.4
1,233,650 + Rv1106c 0.72 +0.2
1,233,651 - Rv1106c 0.73 +0.5
1,234,027 - Rv1107c 0.24 -0.9
1,234,154 - Rv1107c 0.73 +1.1
1,234,366 + Rv1108c 0.12 -0.8
1,234,366 + Rv1108c 0.12 +0.1
1,234,367 - Rv1108c 0.12 -0.2

Or see this region's nucleotide sequence