Experiment: 7H9 with Bedaquiline 0.15 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0198c and Rv0199 are separated by 42 nucleotides Rv0199 and Rv0200 overlap by 4 nucleotides Rv0200 and Rv0201c overlap by 4 nucleotides Rv0201c and Rv0202c overlap by 4 nucleotides
Rv0198c: Rv0198c - Probable zinc metalloprotease Zmp1, at 234,516 to 236,507
Rv0198c
Rv0199: Rv0199 - Probable conserved membrane protein, at 236,550 to 237,209
Rv0199
Rv0200: Rv0200 - Possible conserved transmembrane protein, at 237,206 to 237,895
Rv0200
Rv0201c: Rv0201c - Conserved protein, at 237,892 to 238,395
Rv0201c
Rv0202c: Rv0202c - Probable conserved transmembrane transport protein MmpL11, at 238,392 to 241,292
Rv0202c
Position (kb) 237
238 Strain fitness (log2 ratio) -2
-1
0
1
2 at 236.394 kb on + strand at 236.394 kb on + strand at 236.674 kb on - strand, within Rv0199 at 236.693 kb on - strand, within Rv0199 at 236.772 kb on - strand, within Rv0199 at 236.775 kb on + strand, within Rv0199 at 236.775 kb on + strand, within Rv0199 at 236.988 kb on - strand, within Rv0199 at 237.659 kb on + strand, within Rv0200 at 237.659 kb on + strand, within Rv0200 at 237.659 kb on + strand, within Rv0200 at 238.123 kb on - strand, within Rv0201c at 238.243 kb on + strand, within Rv0201c at 238.300 kb on - strand, within Rv0201c at 238.573 kb on + strand at 238.623 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL remove 236,394 + -0.8 236,394 + -0.2 236,674 - Rv0199 0.19 -2.0 236,693 - Rv0199 0.22 -2.0 236,772 - Rv0199 0.34 -0.9 236,775 + Rv0199 0.34 -2.1 236,775 + Rv0199 0.34 -1.2 236,988 - Rv0199 0.66 -0.1 237,659 + Rv0200 0.66 -1.6 237,659 + Rv0200 0.66 +1.9 237,659 + Rv0200 0.66 -1.1 238,123 - Rv0201c 0.46 +0.4 238,243 + Rv0201c 0.70 +0.7 238,300 - Rv0201c 0.81 -0.2 238,573 + -0.3 238,623 - -1.4
Or see this region's nucleotide sequence