Experiment: 7H9 with Bedaquiline 0.15 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0167 and Rv0168 are separated by 1 nucleotides Rv0168 and Rv0169 are separated by 4 nucleotides Rv0169 and Rv0170 overlap by 4 nucleotides
Rv0167: Rv0167 - Conserved integral membrane protein YrbE1A, at 196,861 to 197,658
Rv0167
Rv0168: Rv0168 - Conserved integral membrane protein YrbE1B, at 197,660 to 198,529
Rv0168
Rv0169: Rv0169 - Mce-family protein Mce1A, at 198,534 to 199,898
Rv0169
Rv0170: Rv0170 - Mce-family protein Mce1B, at 199,895 to 200,935
Rv0170
Position (kb) 198
199
200 Strain fitness (log2 ratio) -4
-3
-2
-1
0
1
2 at 197.721 kb on - strand at 197.721 kb on - strand at 197.816 kb on + strand, within Rv0168 at 198.218 kb on - strand, within Rv0168 at 198.257 kb on + strand, within Rv0168 at 198.278 kb on + strand, within Rv0168 at 198.377 kb on + strand, within Rv0168 at 198.378 kb on - strand, within Rv0168 at 198.378 kb on - strand, within Rv0168 at 198.387 kb on - strand, within Rv0168 at 198.577 kb on - strand at 198.632 kb on - strand at 198.632 kb on - strand at 198.634 kb on - strand at 198.730 kb on - strand, within Rv0169 at 198.826 kb on - strand, within Rv0169 at 198.826 kb on - strand, within Rv0169 at 198.891 kb on + strand, within Rv0169 at 198.892 kb on - strand, within Rv0169 at 199.351 kb on - strand, within Rv0169 at 199.404 kb on + strand, within Rv0169 at 199.404 kb on + strand, within Rv0169 at 199.405 kb on - strand, within Rv0169 at 199.405 kb on - strand, within Rv0169 at 199.441 kb on - strand, within Rv0169 at 199.460 kb on + strand, within Rv0169 at 199.529 kb on + strand, within Rv0169 at 199.530 kb on - strand, within Rv0169 at 199.530 kb on - strand, within Rv0169 at 199.679 kb on + strand, within Rv0169 at 199.680 kb on - strand, within Rv0169 at 199.680 kb on - strand, within Rv0169 at 199.684 kb on - strand, within Rv0169 at 199.816 kb on - strand at 199.843 kb on - strand at 199.881 kb on - strand at 200.002 kb on + strand, within Rv0170 at 200.097 kb on + strand, within Rv0170 at 200.097 kb on + strand, within Rv0170 at 200.162 kb on + strand, within Rv0170 at 200.162 kb on + strand, within Rv0170 at 200.421 kb on + strand, within Rv0170 at 200.563 kb on + strand, within Rv0170 at 200.702 kb on + strand, within Rv0170 at 200.832 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Bedaquiline 0.15 ug/mL remove 197,721 - -1.0 197,721 - -0.9 197,816 + Rv0168 0.18 -1.4 198,218 - Rv0168 0.64 -1.4 198,257 + Rv0168 0.69 +1.9 198,278 + Rv0168 0.71 -1.4 198,377 + Rv0168 0.82 -1.2 198,378 - Rv0168 0.83 -2.4 198,378 - Rv0168 0.83 -1.9 198,387 - Rv0168 0.84 -0.3 198,577 - -1.4 198,632 - -2.3 198,632 - -0.3 198,634 - -1.5 198,730 - Rv0169 0.14 +0.3 198,826 - Rv0169 0.21 +1.9 198,826 - Rv0169 0.21 +1.6 198,891 + Rv0169 0.26 -1.9 198,892 - Rv0169 0.26 -1.1 199,351 - Rv0169 0.60 -1.1 199,404 + Rv0169 0.64 -1.5 199,404 + Rv0169 0.64 -2.2 199,405 - Rv0169 0.64 -1.9 199,405 - Rv0169 0.64 -1.6 199,441 - Rv0169 0.66 +0.0 199,460 + Rv0169 0.68 -0.9 199,529 + Rv0169 0.73 -1.9 199,530 - Rv0169 0.73 -0.3 199,530 - Rv0169 0.73 -4.4 199,679 + Rv0169 0.84 -0.9 199,680 - Rv0169 0.84 -0.6 199,680 - Rv0169 0.84 -1.5 199,684 - Rv0169 0.84 -1.4 199,816 - -0.4 199,843 - -2.0 199,881 - -1.2 200,002 + Rv0170 0.10 -1.1 200,097 + Rv0170 0.19 -0.8 200,097 + Rv0170 0.19 -0.1 200,162 + Rv0170 0.26 -1.1 200,162 + Rv0170 0.26 -1.8 200,421 + Rv0170 0.51 -2.3 200,563 + Rv0170 0.64 -1.2 200,702 + Rv0170 0.78 -0.5 200,832 - -2.4
Or see this region's nucleotide sequence